FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3161282010> ?p ?o ?g. }

• W3161282010 abstract "Abstract Background Cisplatin is a platinum-based chemotherapeutic that damages genomic DNA leading to cell death. It also damages mitochondrial DNA and induces high levels of mitochondrial reactive oxygen species (mtROS), further sensitising cells to apoptosis. Notably, immature oocytes are particularly vulnerable to cisplatin treatment, a common side effect of which is depletion of the primordial follicle reserve, leading to infertility and early menopause. Cisplatin is known to damage the DNA of oocytes, but the possibility that cisplatin also compromises oocyte survival and quality by damaging mitochondria, has not been investigated. To begin to address this question, neonatal mice were treated with saline or cisplatin (2 mg/kg or 4 mg/kg) and the short and long-term impacts on mitochondria in oocytes were characterised. Results At 6 and 24 h after treatment, mitochondrial localisation, mass and ATP content in immature oocytes were similar between groups. However, TMRM staining intensity, a marker of mitochondrial membrane potential, was decreased in immature oocytes from cisplatin treated mice compared to saline treated controls, consistent with the induction of apoptosis. When mice were super ovulated 5 weeks after exposure, the number of mature oocytes harvested from cisplatin treated mice was significantly lower than controls. Mitochondrial localisation, mass, membrane potential and ATP levels showed no differences between groups. Conclusions These findings suggest that mitochondrial dysfunction may contribute to the depletion of the ovarian reserve caused by cisplatin, but long-term impacts on mitochondria may be minimal as those immature oocytes that survive cisplatin treatment develop into mature oocytes with normal mitochondrial parameters." @default.
• W3161282010 created "2021-05-24" @default.
• W3161282010 creator A5029043451 @default.
• W3161282010 creator A5038797982 @default.
• W3161282010 date "2021-05-10" @default.
• W3161282010 modified "2023-10-14" @default.
• W3161282010 title "Evaluation of mitochondria in mouse oocytes following cisplatin exposure" @default.
• W3161282010 cites W1577702842 @default.
• W3161282010 cites W1971564824 @default.
• W3161282010 cites W1982858056 @default.
• W3161282010 cites W1987604182 @default.
• W3161282010 cites W1987702513 @default.
• W3161282010 cites W1989825189 @default.
• W3161282010 cites W2009930978 @default.
• W3161282010 cites W2014777707 @default.
• W3161282010 cites W2045889399 @default.
• W3161282010 cites W2048580070 @default.
• W3161282010 cites W2060279764 @default.
• W3161282010 cites W2061167268 @default.
• W3161282010 cites W2061320431 @default.
• W3161282010 cites W2072220114 @default.
• W3161282010 cites W2076046778 @default.
• W3161282010 cites W2086638852 @default.
• W3161282010 cites W2090898691 @default.
• W3161282010 cites W2117163620 @default.
• W3161282010 cites W2117631891 @default.
• W3161282010 cites W2131415852 @default.
• W3161282010 cites W2131891646 @default.
• W3161282010 cites W2142386008 @default.
• W3161282010 cites W2150149836 @default.
• W3161282010 cites W2150822910 @default.
• W3161282010 cites W2153000015 @default.
• W3161282010 cites W2224205296 @default.
• W3161282010 cites W2319935270 @default.
• W3161282010 cites W2515036978 @default.
• W3161282010 cites W2526146892 @default.
• W3161282010 cites W2536555581 @default.
• W3161282010 cites W2761629122 @default.
• W3161282010 cites W2804421364 @default.
• W3161282010 cites W2884141268 @default.
• W3161282010 cites W2898172972 @default.
• W3161282010 cites W2933979600 @default.
• W3161282010 cites W2942882271 @default.
• W3161282010 cites W2982979216 @default.
• W3161282010 cites W2996922622 @default.
• W3161282010 cites W3004118171 @default.
• W3161282010 cites W945399806 @default.
• W3161282010 doi "https://doi.org/10.1186/s13048-021-00817-w" @default.
• W3161282010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8111953" @default.
• W3161282010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33971923" @default.
• W3161282010 hasPublicationYear "2021" @default.
• W3161282010 type Work @default.
• W3161282010 sameAs 3161282010 @default.
• W3161282010 citedByCount "7" @default.
• W3161282010 countsByYear W31612820102022 @default.
• W3161282010 countsByYear W31612820102023 @default.
• W3161282010 crossrefType "journal-article" @default.
• W3161282010 hasAuthorship W3161282010A5029043451 @default.
• W3161282010 hasAuthorship W3161282010A5038797982 @default.
• W3161282010 hasBestOaLocation W31612820101 @default.
• W3161282010 hasConcept C104317684 @default.
• W3161282010 hasConcept C143425029 @default.
• W3161282010 hasConcept C16685009 @default.
• W3161282010 hasConcept C185592680 @default.
• W3161282010 hasConcept C190283241 @default.
• W3161282010 hasConcept C196843134 @default.
• W3161282010 hasConcept C24586158 @default.
• W3161282010 hasConcept C2776690073 @default.
• W3161282010 hasConcept C2776694085 @default.
• W3161282010 hasConcept C2778239845 @default.
• W3161282010 hasConcept C28859421 @default.
• W3161282010 hasConcept C31573885 @default.
• W3161282010 hasConcept C48349386 @default.
• W3161282010 hasConcept C54355233 @default.
• W3161282010 hasConcept C552990157 @default.
• W3161282010 hasConcept C55493867 @default.
• W3161282010 hasConcept C71924100 @default.
• W3161282010 hasConcept C75385678 @default.
• W3161282010 hasConcept C86803240 @default.
• W3161282010 hasConcept C95444343 @default.
• W3161282010 hasConceptScore W3161282010C104317684 @default.
• W3161282010 hasConceptScore W3161282010C143425029 @default.
• W3161282010 hasConceptScore W3161282010C16685009 @default.
• W3161282010 hasConceptScore W3161282010C185592680 @default.
• W3161282010 hasConceptScore W3161282010C190283241 @default.
• W3161282010 hasConceptScore W3161282010C196843134 @default.
• W3161282010 hasConceptScore W3161282010C24586158 @default.
• W3161282010 hasConceptScore W3161282010C2776690073 @default.
• W3161282010 hasConceptScore W3161282010C2776694085 @default.
• W3161282010 hasConceptScore W3161282010C2778239845 @default.
• W3161282010 hasConceptScore W3161282010C28859421 @default.
• W3161282010 hasConceptScore W3161282010C31573885 @default.
• W3161282010 hasConceptScore W3161282010C48349386 @default.
• W3161282010 hasConceptScore W3161282010C54355233 @default.
• W3161282010 hasConceptScore W3161282010C552990157 @default.
• W3161282010 hasConceptScore W3161282010C55493867 @default.
• W3161282010 hasConceptScore W3161282010C71924100 @default.
• W3161282010 hasConceptScore W3161282010C75385678 @default.
• W3161282010 hasConceptScore W3161282010C86803240 @default.
• W3161282010 hasConceptScore W3161282010C95444343 @default.

• next