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- W3161297923 abstract "Oncology has seen growing use of newly developed targeted therapies. Although this has resulted in dramatic improvements in progression-free and overall survival, challenges in the management of toxicities related to longer-term treatment of these therapies have also become evident. Although a targeted approach often exploits the differences between cancer cells and noncancer cells, overlap in signaling pathways necessary for the maintenance of function and survival in multiple cell types has resulted in systemic toxicities. In particular, cardiovascular toxicities are of important concern. In this review, we highlight several targeted therapies commonly used across a variety of cancer types, including HER2 (human epidermal growth factor receptor 2)+ targeted therapies, tyrosine kinase inhibitors, immune checkpoint inhibitors, proteasome inhibitors, androgen deprivation therapies, and MEK (mitogen-activated protein kinase kinase)/BRAF (v-raf murine sarcoma viral oncogene homolog B) inhibitors. We present the oncological indications, heart failure incidence, hypothesized mechanisms of cardiotoxicity, and potential mechanistic rationale for specific cardioprotective strategies." @default.
- W3161297923 created "2021-05-24" @default.
- W3161297923 creator A5004284766 @default.
- W3161297923 creator A5041625226 @default.
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- W3161297923 creator A5046737949 @default.
- W3161297923 creator A5066635849 @default.
- W3161297923 creator A5084265906 @default.
- W3161297923 date "2021-05-14" @default.
- W3161297923 modified "2023-10-18" @default.
- W3161297923 title "Heart Failure With Targeted Cancer Therapies" @default.
- W3161297923 cites W1574315642 @default.
- W3161297923 cites W1607492210 @default.
- W3161297923 cites W1907991309 @default.
- W3161297923 cites W1954317670 @default.
- W3161297923 cites W1965024282 @default.
- W3161297923 cites W1978752343 @default.
- W3161297923 cites W1982393730 @default.
- W3161297923 cites W1985864219 @default.
- W3161297923 cites W1993458335 @default.
- W3161297923 cites W2003022043 @default.
- W3161297923 cites W2009810419 @default.
- W3161297923 cites W2015860087 @default.
- W3161297923 cites W2016521491 @default.
- W3161297923 cites W2027671567 @default.
- W3161297923 cites W2035642783 @default.
- W3161297923 cites W2035739677 @default.
- W3161297923 cites W2041460501 @default.
- W3161297923 cites W2045570557 @default.
- W3161297923 cites W2048162676 @default.
- W3161297923 cites W2050422354 @default.
- W3161297923 cites W2050674912 @default.
- W3161297923 cites W2056579307 @default.
- W3161297923 cites W2060275872 @default.
- W3161297923 cites W2060517558 @default.
- W3161297923 cites W2061460689 @default.
- W3161297923 cites W2063842030 @default.
- W3161297923 cites W2076067786 @default.
- W3161297923 cites W2083350649 @default.
- W3161297923 cites W2089394474 @default.
- W3161297923 cites W2096387850 @default.
- W3161297923 cites W2096847688 @default.
- W3161297923 cites W2098775844 @default.
- W3161297923 cites W2098998490 @default.
- W3161297923 cites W2099359513 @default.
- W3161297923 cites W2100940126 @default.
- W3161297923 cites W2102088366 @default.
- W3161297923 cites W2104507960 @default.
- W3161297923 cites W2107089546 @default.
- W3161297923 cites W2108548563 @default.
- W3161297923 cites W2110534364 @default.
- W3161297923 cites W2111092101 @default.
- W3161297923 cites W2112099875 @default.
- W3161297923 cites W2119776733 @default.
- W3161297923 cites W2120608237 @default.
- W3161297923 cites W2120636426 @default.
- W3161297923 cites W2121279599 @default.
- W3161297923 cites W2122657692 @default.
- W3161297923 cites W2126970264 @default.
- W3161297923 cites W2128863027 @default.
- W3161297923 cites W2131286608 @default.
- W3161297923 cites W2133105825 @default.
- W3161297923 cites W2136449685 @default.
- W3161297923 cites W2137467802 @default.
- W3161297923 cites W2139281245 @default.
- W3161297923 cites W2140419562 @default.
- W3161297923 cites W2140765540 @default.
- W3161297923 cites W2141068637 @default.
- W3161297923 cites W2141259519 @default.
- W3161297923 cites W2143959240 @default.
- W3161297923 cites W2145638206 @default.
- W3161297923 cites W2145725580 @default.
- W3161297923 cites W2147646179 @default.
- W3161297923 cites W2148643283 @default.
- W3161297923 cites W2151490188 @default.
- W3161297923 cites W2153331460 @default.
- W3161297923 cites W2153362990 @default.
- W3161297923 cites W2155591792 @default.
- W3161297923 cites W2156078931 @default.
- W3161297923 cites W2158474413 @default.
- W3161297923 cites W2158945674 @default.
- W3161297923 cites W2159751849 @default.
- W3161297923 cites W2159781346 @default.
- W3161297923 cites W2163188200 @default.
- W3161297923 cites W2163495162 @default.
- W3161297923 cites W2166918329 @default.
- W3161297923 cites W2168009222 @default.
- W3161297923 cites W2169442017 @default.
- W3161297923 cites W2170524644 @default.
- W3161297923 cites W2171487703 @default.
- W3161297923 cites W2220134252 @default.
- W3161297923 cites W2238402870 @default.
- W3161297923 cites W2273608446 @default.
- W3161297923 cites W2285275113 @default.
- W3161297923 cites W2298838354 @default.
- W3161297923 cites W2312804644 @default.
- W3161297923 cites W2313546112 @default.
- W3161297923 cites W2317660163 @default.