Matches in SemOpenAlex for { <https://semopenalex.org/work/W3161315869> ?p ?o ?g. }
- W3161315869 endingPage "2713" @default.
- W3161315869 startingPage "2700" @default.
- W3161315869 abstract "Abstract B lymphocyte development is dependent on the interplay between the chromatin landscape and lineage-specific transcription factors. It has been suggested that B lineage commitment is associated with major changes in the nuclear chromatin environment, proposing a critical role for lineage-specific transcription factors in the formation of the epigenetic landscape. In this report, we have used chromosome conformation capture in combination with assay for transposase-accessible chromatin sequencing analysis to enable highly efficient annotation of both proximal and distal transcriptional control elements to genes activated in B lineage specification in mice. A large majority of these genes were annotated to at least one regulatory element with an accessible chromatin configuration in multipotent progenitors. Furthermore, the majority of binding sites for the key regulators of B lineage specification, EBF1 and PAX5, occurred in already accessible regions. EBF1 did, however, cause a dynamic change in assay for transposase-accessible chromatin accessibility and was critical for an increase in distal promoter–enhancer interactions. Our data unravel an extensive epigenetic priming at regulatory elements annotated to lineage-restricted genes and provide insight into the interplay between the epigenetic landscape and transcription factors in cell specification." @default.
- W3161315869 created "2021-05-24" @default.
- W3161315869 creator A5004912814 @default.
- W3161315869 creator A5005991028 @default.
- W3161315869 creator A5021313085 @default.
- W3161315869 creator A5022636472 @default.
- W3161315869 creator A5028285417 @default.
- W3161315869 creator A5030636952 @default.
- W3161315869 creator A5062610313 @default.
- W3161315869 creator A5064474850 @default.
- W3161315869 creator A5066870276 @default.
- W3161315869 creator A5075258865 @default.
- W3161315869 creator A5084379572 @default.
- W3161315869 creator A5084856046 @default.
- W3161315869 creator A5088356761 @default.
- W3161315869 date "2021-06-01" @default.
- W3161315869 modified "2023-10-01" @default.
- W3161315869 title "B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors" @default.
- W3161315869 cites W1884785360 @default.
- W3161315869 cites W1912537483 @default.
- W3161315869 cites W1963617750 @default.
- W3161315869 cites W1964951991 @default.
- W3161315869 cites W1968561263 @default.
- W3161315869 cites W1971677256 @default.
- W3161315869 cites W1971946672 @default.
- W3161315869 cites W1973054937 @default.
- W3161315869 cites W1977123213 @default.
- W3161315869 cites W1979911126 @default.
- W3161315869 cites W1984065010 @default.
- W3161315869 cites W1996448420 @default.
- W3161315869 cites W2002424170 @default.
- W3161315869 cites W2003371248 @default.
- W3161315869 cites W2008735740 @default.
- W3161315869 cites W2014677321 @default.
- W3161315869 cites W2018310880 @default.
- W3161315869 cites W2021189802 @default.
- W3161315869 cites W2024090882 @default.
- W3161315869 cites W2024791560 @default.
- W3161315869 cites W2035502959 @default.
- W3161315869 cites W2035671523 @default.
- W3161315869 cites W2049470832 @default.
- W3161315869 cites W2062247105 @default.
- W3161315869 cites W2062618476 @default.
- W3161315869 cites W2063807804 @default.
- W3161315869 cites W2064993419 @default.
- W3161315869 cites W2065608157 @default.
- W3161315869 cites W2070745300 @default.
- W3161315869 cites W2074521753 @default.
- W3161315869 cites W2076038738 @default.
- W3161315869 cites W2077311610 @default.
- W3161315869 cites W2079687343 @default.
- W3161315869 cites W2081255800 @default.
- W3161315869 cites W2083047727 @default.
- W3161315869 cites W2085316173 @default.
- W3161315869 cites W2087549177 @default.
- W3161315869 cites W2093931465 @default.
- W3161315869 cites W2102782482 @default.
- W3161315869 cites W2105607204 @default.
- W3161315869 cites W2105707485 @default.
- W3161315869 cites W2107249189 @default.
- W3161315869 cites W2108234281 @default.
- W3161315869 cites W2111519012 @default.
- W3161315869 cites W2117757143 @default.
- W3161315869 cites W2124985265 @default.
- W3161315869 cites W2125263315 @default.
- W3161315869 cites W2128016314 @default.
- W3161315869 cites W2136784327 @default.
- W3161315869 cites W2137511124 @default.
- W3161315869 cites W2139285351 @default.
- W3161315869 cites W2151645052 @default.
- W3161315869 cites W2153562609 @default.
- W3161315869 cites W2157838058 @default.
- W3161315869 cites W2159686118 @default.
- W3161315869 cites W2163531396 @default.
- W3161315869 cites W2163584800 @default.
- W3161315869 cites W2166773843 @default.
- W3161315869 cites W2167279371 @default.
- W3161315869 cites W2169456326 @default.
- W3161315869 cites W2170311955 @default.
- W3161315869 cites W2170551349 @default.
- W3161315869 cites W2171808845 @default.
- W3161315869 cites W2171863027 @default.
- W3161315869 cites W2179438025 @default.
- W3161315869 cites W2180261404 @default.
- W3161315869 cites W2184235535 @default.
- W3161315869 cites W2185693210 @default.
- W3161315869 cites W2190545194 @default.
- W3161315869 cites W2301861748 @default.
- W3161315869 cites W2470266050 @default.
- W3161315869 cites W2521871652 @default.
- W3161315869 cites W2548584258 @default.
- W3161315869 cites W2562443513 @default.
- W3161315869 cites W2748366037 @default.
- W3161315869 cites W2750416916 @default.
- W3161315869 cites W2785603098 @default.
- W3161315869 cites W2786450858 @default.
- W3161315869 cites W2808211240 @default.
- W3161315869 cites W2887206273 @default.