FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3161321544> ?p ?o ?g. }

• W3161321544 endingPage "e0251411" @default.
• W3161321544 startingPage "e0251411" @default.
• W3161321544 abstract "Cells exert traction forces on the extracellular matrix to which they are adhered through the formation of focal adhesions. Spatial-temporal regulation of traction forces is crucial in cell adhesion, migration, cellular division, and remodeling of the extracellular matrix. By cultivating cells on polyacrylamide hydrogels of different stiffness we were able to investigate the effects of substrate stiffness on the generation of cellular traction forces by Traction Force Microscopy (TFM), and characterize the molecular dynamics of the focal adhesion protein zyxin by Fluorescence Correlation Spectroscopy (FCS) and Fluorescence Recovery After Photobleaching (FRAP). As the rigidity of the substrate increases, we observed an increment of both, cellular traction generation and zyxin residence time at the focal adhesions, while its diffusion would not be altered. Moreover, we found a positive correlation between the traction forces exerted by cells and the residence time of zyxin at the substrate elasticities studied. We found that this correlation persists at the subcellular level, even if there is no variation in substrate stiffness, revealing that focal adhesions that exert greater traction present longer residence time for zyxin, i.e., zyxin protein has less probability to dissociate from the focal adhesion." @default.
• W3161321544 created "2021-05-24" @default.
• W3161321544 creator A5021646850 @default.
• W3161321544 creator A5055457483 @default.
• W3161321544 creator A5055582708 @default.
• W3161321544 creator A5069762001 @default.
• W3161321544 date "2021-05-11" @default.
• W3161321544 modified "2023-10-16" @default.
• W3161321544 title "Correlation of cellular traction forces and dissociation kinetics of adhesive protein zyxin revealed by multi-parametric live cell microscopy" @default.
• W3161321544 cites W1964793873 @default.
• W3161321544 cites W1965933207 @default.
• W3161321544 cites W1982957540 @default.
• W3161321544 cites W1989095124 @default.
• W3161321544 cites W1993006648 @default.
• W3161321544 cites W1996757213 @default.
• W3161321544 cites W2010227280 @default.
• W3161321544 cites W2029561530 @default.
• W3161321544 cites W2041033836 @default.
• W3161321544 cites W2042936107 @default.
• W3161321544 cites W2051504714 @default.
• W3161321544 cites W2063802789 @default.
• W3161321544 cites W2074572112 @default.
• W3161321544 cites W2081910439 @default.
• W3161321544 cites W2085767196 @default.
• W3161321544 cites W2089191944 @default.
• W3161321544 cites W2097539516 @default.
• W3161321544 cites W2097697809 @default.
• W3161321544 cites W2110148884 @default.
• W3161321544 cites W2129314813 @default.
• W3161321544 cites W2135165925 @default.
• W3161321544 cites W2142219685 @default.
• W3161321544 cites W2147924290 @default.
• W3161321544 cites W2149667112 @default.
• W3161321544 cites W2165381688 @default.
• W3161321544 cites W2166052672 @default.
• W3161321544 cites W2167279371 @default.
• W3161321544 cites W2171484340 @default.
• W3161321544 cites W2611640387 @default.
• W3161321544 cites W2809498605 @default.
• W3161321544 cites W2949673162 @default.
• W3161321544 cites W4240274314 @default.
• W3161321544 doi "https://doi.org/10.1371/journal.pone.0251411" @default.
• W3161321544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8112686" @default.
• W3161321544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33974655" @default.
• W3161321544 hasPublicationYear "2021" @default.
• W3161321544 type Work @default.
• W3161321544 sameAs 3161321544 @default.
• W3161321544 citedByCount "5" @default.
• W3161321544 countsByYear W31613215442021 @default.
• W3161321544 countsByYear W31613215442022 @default.
• W3161321544 countsByYear W31613215442023 @default.
• W3161321544 crossrefType "journal-article" @default.
• W3161321544 hasAuthorship W3161321544A5021646850 @default.
• W3161321544 hasAuthorship W3161321544A5055457483 @default.
• W3161321544 hasAuthorship W3161321544A5055582708 @default.
• W3161321544 hasAuthorship W3161321544A5069762001 @default.
• W3161321544 hasBestOaLocation W31613215441 @default.
• W3161321544 hasConcept C121332964 @default.
• W3161321544 hasConcept C12554922 @default.
• W3161321544 hasConcept C137738243 @default.
• W3161321544 hasConcept C1491633281 @default.
• W3161321544 hasConcept C151166631 @default.
• W3161321544 hasConcept C185592680 @default.
• W3161321544 hasConcept C189165786 @default.
• W3161321544 hasConcept C26659971 @default.
• W3161321544 hasConcept C2993775838 @default.
• W3161321544 hasConcept C32520587 @default.
• W3161321544 hasConcept C41625074 @default.
• W3161321544 hasConcept C55493867 @default.
• W3161321544 hasConcept C85789140 @default.
• W3161321544 hasConcept C86803240 @default.
• W3161321544 hasConcept C95444343 @default.
• W3161321544 hasConcept C97355855 @default.
• W3161321544 hasConceptScore W3161321544C121332964 @default.
• W3161321544 hasConceptScore W3161321544C12554922 @default.
• W3161321544 hasConceptScore W3161321544C137738243 @default.
• W3161321544 hasConceptScore W3161321544C1491633281 @default.
• W3161321544 hasConceptScore W3161321544C151166631 @default.
• W3161321544 hasConceptScore W3161321544C185592680 @default.
• W3161321544 hasConceptScore W3161321544C189165786 @default.
• W3161321544 hasConceptScore W3161321544C26659971 @default.
• W3161321544 hasConceptScore W3161321544C2993775838 @default.
• W3161321544 hasConceptScore W3161321544C32520587 @default.
• W3161321544 hasConceptScore W3161321544C41625074 @default.
• W3161321544 hasConceptScore W3161321544C55493867 @default.
• W3161321544 hasConceptScore W3161321544C85789140 @default.
• W3161321544 hasConceptScore W3161321544C86803240 @default.
• W3161321544 hasConceptScore W3161321544C95444343 @default.
• W3161321544 hasConceptScore W3161321544C97355855 @default.
• W3161321544 hasFunder F4320323257 @default.
• W3161321544 hasFunder F4320334832 @default.
• W3161321544 hasIssue "5" @default.
• W3161321544 hasLocation W31613215441 @default.
• W3161321544 hasLocation W31613215442 @default.
• W3161321544 hasLocation W31613215443 @default.
• W3161321544 hasLocation W31613215444 @default.
• W3161321544 hasOpenAccess W3161321544 @default.
• W3161321544 hasPrimaryLocation W31613215441 @default.

• next