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- W3161392205 abstract "Chromosome instability (CIN) has been repeatedly associated with aging and progeroid phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic cascades leading to neurodegeneration in late adulthood. Alternatively, CIN and aneuploidy (chromosomal loss/gain) syndromes exhibit accelerated aging phenotypes. Molecularly, cellular senescence, which seems to be mediated by CIN and aneuploidy, is likely to contribute to brain aging in health and disease. However, there is no consensus about the occurrence of CIN in the aging brain. As a result, the role of CIN/somatic aneuploidy in normal and pathological brain aging is a matter of debate. Still, taking into account the effects of CIN on cellular homeostasis, the possibility of involvement in brain aging is highly likely. More importantly, the CIN contribution to neuronal cell death may be responsible for neurodegeneration and the aging-related deterioration of the brain. The loss of CIN-affected neurons probably underlies the contradiction between reports addressing ontogenetic changes of karyotypes within the aged brain. In future studies, the combination of single-cell visualization and whole-genome techniques with systems biology methods would certainly define the intrinsic role of CIN in the aging of the normal and diseased brain." @default.
- W3161392205 created "2021-05-24" @default.
- W3161392205 creator A5054875291 @default.
- W3161392205 creator A5055554212 @default.
- W3161392205 creator A5056727661 @default.
- W3161392205 creator A5086121932 @default.
- W3161392205 date "2021-05-19" @default.
- W3161392205 modified "2023-10-17" @default.
- W3161392205 title "Chromosome Instability, Aging and Brain Diseases" @default.
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- W3161392205 doi "https://doi.org/10.3390/cells10051256" @default.
- W3161392205 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8161106" @default.
- W3161392205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34069648" @default.