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• W3161427556 endingPage "e1009516" @default.
• W3161427556 startingPage "e1009516" @default.
• W3161427556 abstract "Adenosine deaminase acting on RNA 1 (ADAR1), an enzyme responsible for adenosine-to-inosine RNA editing, is composed of two isoforms: nuclear p110 and cytoplasmic p150. Deletion of Adar1 or Adar1 p150 genes in mice results in embryonic lethality with overexpression of interferon-stimulating genes (ISGs), caused by the aberrant recognition of unedited endogenous transcripts by melanoma differentiation-associated protein 5 (MDA5). However, among numerous RNA editing sites, how many RNA sites require editing, especially by ADAR1 p150, to avoid MDA5 activation and whether ADAR1 p110 contributes to this function remains elusive. In particular, ADAR1 p110 is abundant in the mouse brain where a subtle amount of ADAR1 p150 is expressed, whereas ADAR1 mutations cause Aicardi–Goutières syndrome, in which the brain is one of the most affected organs accompanied by the elevated expression of ISGs. Therefore, understanding RNA editing–mediated prevention of MDA5 activation in the brain is especially important. Here, we established Adar1 p110 –specific knockout mice, in which the upregulated expression of ISGs was not observed. This result suggests that ADAR1 p150–mediated RNA editing is enough to suppress MDA5 activation. Therefore, we further created Adar1 p110 / Adar2 double knockout mice to identify ADAR1 p150–mediated editing sites. This analysis demonstrated that although the elevated expression of ISGs was not observed, only less than 2% of editing sites were preserved in the brains of Adar1 p110 / Adar2 double knockout mice. Of note, we found that some sites were highly edited, which was comparable to those found in wild-type mice, indicating the presence of ADAR1 p150–specific sites. These data suggest that RNA editing at a very limited sites, which is mediated by a subtle amount of ADAR1 p150, is sufficient to prevents MDA5 activation, at least in the mouse brain." @default.
• W3161427556 created "2021-05-24" @default.
• W3161427556 creator A5001597010 @default.
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• W3161427556 date "2021-05-13" @default.
• W3161427556 modified "2023-10-16" @default.
• W3161427556 title "RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain" @default.
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• W3161427556 cites W2001416012 @default.
• W3161427556 cites W2003816534 @default.
• W3161427556 cites W2005259783 @default.
• W3161427556 cites W2006462446 @default.
• W3161427556 cites W2008476211 @default.
• W3161427556 cites W2011536289 @default.
• W3161427556 cites W2012800815 @default.
• W3161427556 cites W2029728313 @default.
• W3161427556 cites W2034148234 @default.
• W3161427556 cites W2040839903 @default.
• W3161427556 cites W2043724929 @default.
• W3161427556 cites W2046641567 @default.
• W3161427556 cites W2049110540 @default.
• W3161427556 cites W2053078702 @default.
• W3161427556 cites W2054421148 @default.
• W3161427556 cites W2054584406 @default.
• W3161427556 cites W2057068701 @default.
• W3161427556 cites W2059439438 @default.
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• W3161427556 cites W2062355463 @default.
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• W3161427556 cites W2086561953 @default.
• W3161427556 cites W2094833237 @default.
• W3161427556 cites W2100984579 @default.
• W3161427556 cites W2102278945 @default.
• W3161427556 cites W2114379433 @default.
• W3161427556 cites W2115221577 @default.
• W3161427556 cites W2119180969 @default.
• W3161427556 cites W2120276739 @default.
• W3161427556 cites W2123497973 @default.
• W3161427556 cites W2124626885 @default.
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• W3161427556 cites W2132002570 @default.
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• W3161427556 cites W2171597027 @default.
• W3161427556 cites W2173666904 @default.
• W3161427556 cites W2173732482 @default.
• W3161427556 cites W2232851097 @default.
• W3161427556 cites W2556542827 @default.
• W3161427556 cites W2608912729 @default.
• W3161427556 cites W2753498475 @default.
• W3161427556 cites W2762506271 @default.
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• W3161427556 cites W2898487027 @default.
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• W3161427556 cites W2998988912 @default.
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• W3161427556 doi "https://doi.org/10.1371/journal.pgen.1009516" @default.
• W3161427556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8118328" @default.
• W3161427556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33983932" @default.
• W3161427556 hasPublicationYear "2021" @default.
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