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- W3161495384 abstract "Alterations to the cerebral microcirculation have been recognized to play a crucial role in the development of neurodegenerative disorders. However, the exact role of the microvascular alterations in the pathophysiological mechanisms often remains poorly understood. The early detection of changes in microcirculation and cerebral blood flow (CBF) can be used to get a better understanding of underlying disease mechanisms. This could be an important step towards the development of new treatment approaches. Animal models allow for the study of the disease mechanism at several stages of development, before the onset of clinical symptoms, and the verification with invasive imaging techniques. Specifically, pre-clinical magnetic resonance imaging (MRI) is an important tool for the development and validation of MRI sequences under clinically relevant conditions. This article reviews MRI strategies providing indirect non-invasive measurements of microvascular changes in the rodent brain that can be used for early detection and characterization of neurodegenerative disorders. The perfusion MRI techniques: Dynamic Contrast Enhanced (DCE), Dynamic Susceptibility Contrast Enhanced (DSC) and Arterial Spin Labeling (ASL), will be discussed, followed by less established imaging strategies used to analyze the cerebral microcirculation: Intravoxel Incoherent Motion (IVIM), Vascular Space Occupancy (VASO), Steady-State Susceptibility Contrast (SSC), Vessel size imaging, SAGE-based DSC, Phase Contrast Flow (PC) Quantitative Susceptibility Mapping (QSM) and quantitative Blood-Oxygenation-Level-Dependent (qBOLD). We will emphasize the advantages and limitations of each strategy, in particular on applications for high-field MRI in the rodent’s brain." @default.
- W3161495384 created "2021-05-24" @default.
- W3161495384 creator A5004293803 @default.
- W3161495384 creator A5006106713 @default.
- W3161495384 creator A5058982648 @default.
- W3161495384 date "2021-05-21" @default.
- W3161495384 modified "2023-10-13" @default.
- W3161495384 title "Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations" @default.
- W3161495384 cites W1485368148 @default.
- W3161495384 cites W1489731118 @default.
- W3161495384 cites W1531764706 @default.
- W3161495384 cites W1541626561 @default.
- W3161495384 cites W1565215438 @default.
- W3161495384 cites W1599159471 @default.
- W3161495384 cites W1629709991 @default.
- W3161495384 cites W1654643503 @default.
- W3161495384 cites W1688597837 @default.
- W3161495384 cites W1820864022 @default.
- W3161495384 cites W1837885345 @default.
- W3161495384 cites W1855314914 @default.
- W3161495384 cites W1883700095 @default.
- W3161495384 cites W1952418028 @default.
- W3161495384 cites W1969212417 @default.
- W3161495384 cites W1970936375 @default.
- W3161495384 cites W1975930385 @default.
- W3161495384 cites W1976863536 @default.
- W3161495384 cites W1980748384 @default.
- W3161495384 cites W1986728683 @default.
- W3161495384 cites W1989854445 @default.
- W3161495384 cites W1990194861 @default.
- W3161495384 cites W1993852907 @default.
- W3161495384 cites W1998739717 @default.
- W3161495384 cites W2002071256 @default.
- W3161495384 cites W2003617423 @default.
- W3161495384 cites W2004916800 @default.
- W3161495384 cites W2007192266 @default.
- W3161495384 cites W2008134326 @default.
- W3161495384 cites W2011103593 @default.
- W3161495384 cites W2011840446 @default.
- W3161495384 cites W2012602334 @default.
- W3161495384 cites W2014938866 @default.
- W3161495384 cites W2015363282 @default.
- W3161495384 cites W2018051866 @default.
- W3161495384 cites W2019758497 @default.
- W3161495384 cites W2019865884 @default.
- W3161495384 cites W2019949513 @default.
- W3161495384 cites W2021496866 @default.
- W3161495384 cites W2023609264 @default.
- W3161495384 cites W2024047266 @default.
- W3161495384 cites W2024762951 @default.
- W3161495384 cites W2028003308 @default.
- W3161495384 cites W2030872568 @default.
- W3161495384 cites W2031021651 @default.
- W3161495384 cites W2036305093 @default.
- W3161495384 cites W2037506613 @default.
- W3161495384 cites W2038106425 @default.
- W3161495384 cites W2039385259 @default.
- W3161495384 cites W2039449582 @default.
- W3161495384 cites W2041148826 @default.
- W3161495384 cites W2042098439 @default.
- W3161495384 cites W2044132027 @default.
- W3161495384 cites W2044704205 @default.
- W3161495384 cites W2045026301 @default.
- W3161495384 cites W2046469028 @default.
- W3161495384 cites W204998232 @default.
- W3161495384 cites W2050900769 @default.
- W3161495384 cites W2052179106 @default.
- W3161495384 cites W2052329686 @default.
- W3161495384 cites W2053313273 @default.
- W3161495384 cites W2055195941 @default.
- W3161495384 cites W2055447603 @default.
- W3161495384 cites W2055656669 @default.
- W3161495384 cites W2056022329 @default.
- W3161495384 cites W2057746943 @default.
- W3161495384 cites W2057941397 @default.
- W3161495384 cites W2059756358 @default.
- W3161495384 cites W2062244525 @default.
- W3161495384 cites W2062430699 @default.
- W3161495384 cites W2064533924 @default.
- W3161495384 cites W2067508420 @default.
- W3161495384 cites W2069444004 @default.
- W3161495384 cites W2069470613 @default.
- W3161495384 cites W2069734928 @default.
- W3161495384 cites W2070946874 @default.
- W3161495384 cites W2071714163 @default.
- W3161495384 cites W2072307287 @default.
- W3161495384 cites W2072579321 @default.
- W3161495384 cites W2073748140 @default.
- W3161495384 cites W2074274705 @default.
- W3161495384 cites W2077166252 @default.
- W3161495384 cites W2077466520 @default.
- W3161495384 cites W2078200335 @default.
- W3161495384 cites W2079606458 @default.
- W3161495384 cites W2082914617 @default.
- W3161495384 cites W2085512859 @default.
- W3161495384 cites W2086047637 @default.
- W3161495384 cites W2090054278 @default.
- W3161495384 cites W2093778404 @default.