FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3161515411> ?p ?o ?g. }

• W3161515411 endingPage "542" @default.
• W3161515411 startingPage "542" @default.
• W3161515411 abstract "Pertussis is an acute respiratory tract infection caused by Bordetella pertussis. Even though its current vaccine coverage is relatively broad, they still have some shortcomings such as short protection time and might be incapable of blocking the spread of the disease. In this study, we developed new pertussis vaccine candidates by separately fusing three pertussis antigens (B. pertussis fimbriae 2 “Fim2”, pertussis toxin S1 subunit “PtxS1”, and filamentous hemagglutinin “FHA1877–2250”) to each of two immune-boosting carrier proteins (B subunits of AB5 toxin family: cholera toxin B subunit “CTB” and shiga toxin B subunit “StxB”). We then immunized mice with these fusion antigens and found that they significantly increased the serum antibody titers and elicited high bactericidal activity against B. pertussis. After CTB-or StxB-fused antigen-immunized mice were challenged with a non-lethal dose of B. pertussis, the bacterial loads in different tissues of these mice were significantly reduced, and their lung damage was nearly invisible. Furthermore, we also demonstrated that these candidate vaccines could provide strong prophylactic effects against a lethal challenge with B. pertussis. Overall, our candidate vaccines conferred better immune protection to mice compared with pertussis antigen alone. This B5 subunit-based vaccine strategy provides a promising option for vaccine design." @default.
• W3161515411 created "2021-05-24" @default.
• W3161515411 creator A5003426297 @default.
• W3161515411 creator A5018309024 @default.
• W3161515411 creator A5021680253 @default.
• W3161515411 creator A5023340710 @default.
• W3161515411 creator A5040500028 @default.
• W3161515411 creator A5044988420 @default.
• W3161515411 creator A5051081451 @default.
• W3161515411 creator A5055298217 @default.
• W3161515411 creator A5060885835 @default.
• W3161515411 creator A5071070344 @default.
• W3161515411 creator A5073767435 @default.
• W3161515411 date "2021-05-21" @default.
• W3161515411 modified "2023-09-27" @default.
• W3161515411 title "Expression of Bordetella pertussis Antigens Fused to Different Vectors and Their Effectiveness as Vaccines" @default.
• W3161515411 cites W1565974182 @default.
• W3161515411 cites W1967969801 @default.
• W3161515411 cites W1998735875 @default.
• W3161515411 cites W2051258807 @default.
• W3161515411 cites W2063304453 @default.
• W3161515411 cites W2068326083 @default.
• W3161515411 cites W2094040542 @default.
• W3161515411 cites W2104124970 @default.
• W3161515411 cites W2117434190 @default.
• W3161515411 cites W2158485209 @default.
• W3161515411 cites W2164212216 @default.
• W3161515411 cites W2341479591 @default.
• W3161515411 cites W2342896712 @default.
• W3161515411 cites W2440721038 @default.
• W3161515411 cites W2467849334 @default.
• W3161515411 cites W2588169923 @default.
• W3161515411 cites W2781553008 @default.
• W3161515411 cites W2782729233 @default.
• W3161515411 cites W2800699938 @default.
• W3161515411 cites W2888033438 @default.
• W3161515411 cites W2889939745 @default.
• W3161515411 cites W2943978096 @default.
• W3161515411 cites W2953736961 @default.
• W3161515411 cites W2971976088 @default.
• W3161515411 cites W3011977480 @default.
• W3161515411 cites W3016894464 @default.
• W3161515411 cites W3040843673 @default.
• W3161515411 cites W3045727842 @default.
• W3161515411 cites W3047120178 @default.
• W3161515411 cites W3082074638 @default.
• W3161515411 cites W3137417962 @default.
• W3161515411 doi "https://doi.org/10.3390/vaccines9060542" @default.
• W3161515411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8224380" @default.
• W3161515411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34064136" @default.
• W3161515411 hasPublicationYear "2021" @default.
• W3161515411 type Work @default.
• W3161515411 sameAs 3161515411 @default.
• W3161515411 citedByCount "4" @default.
• W3161515411 countsByYear W31615154112021 @default.
• W3161515411 countsByYear W31615154112022 @default.
• W3161515411 crossrefType "journal-article" @default.
• W3161515411 hasAuthorship W3161515411A5003426297 @default.
• W3161515411 hasAuthorship W3161515411A5018309024 @default.
• W3161515411 hasAuthorship W3161515411A5021680253 @default.
• W3161515411 hasAuthorship W3161515411A5023340710 @default.
• W3161515411 hasAuthorship W3161515411A5040500028 @default.
• W3161515411 hasAuthorship W3161515411A5044988420 @default.
• W3161515411 hasAuthorship W3161515411A5051081451 @default.
• W3161515411 hasAuthorship W3161515411A5055298217 @default.
• W3161515411 hasAuthorship W3161515411A5060885835 @default.
• W3161515411 hasAuthorship W3161515411A5071070344 @default.
• W3161515411 hasAuthorship W3161515411A5073767435 @default.
• W3161515411 hasBestOaLocation W31615154111 @default.
• W3161515411 hasConcept C147483822 @default.
• W3161515411 hasConcept C159047783 @default.
• W3161515411 hasConcept C170493617 @default.
• W3161515411 hasConcept C196419574 @default.
• W3161515411 hasConcept C203014093 @default.
• W3161515411 hasConcept C22070199 @default.
• W3161515411 hasConcept C2777582894 @default.
• W3161515411 hasConcept C2779214499 @default.
• W3161515411 hasConcept C2779634000 @default.
• W3161515411 hasConcept C2780801004 @default.
• W3161515411 hasConcept C49773422 @default.
• W3161515411 hasConcept C523546767 @default.
• W3161515411 hasConcept C54355233 @default.
• W3161515411 hasConcept C55493867 @default.
• W3161515411 hasConcept C71924100 @default.
• W3161515411 hasConcept C80631254 @default.
• W3161515411 hasConcept C8439097 @default.
• W3161515411 hasConcept C86803240 @default.
• W3161515411 hasConcept C8891405 @default.
• W3161515411 hasConcept C89423630 @default.
• W3161515411 hasConceptScore W3161515411C147483822 @default.
• W3161515411 hasConceptScore W3161515411C159047783 @default.
• W3161515411 hasConceptScore W3161515411C170493617 @default.
• W3161515411 hasConceptScore W3161515411C196419574 @default.
• W3161515411 hasConceptScore W3161515411C203014093 @default.
• W3161515411 hasConceptScore W3161515411C22070199 @default.
• W3161515411 hasConceptScore W3161515411C2777582894 @default.
• W3161515411 hasConceptScore W3161515411C2779214499 @default.
• W3161515411 hasConceptScore W3161515411C2779634000 @default.

• next