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- W3161571428 endingPage "584" @default.
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- W3161571428 abstract "The Mycobacterium tuberculosis complex (MTBC) is a group of bacteria that cause tuberculosis (TB) in diverse hosts, including captive and free-ranging wildlife species. There is significant research interest in developing immunodiagnostic tests for TB that are both rapid and reliable, to underpin disease surveillance and control. The aim of this study was to carry out an updated review of diagnostics for TB in non-bovid species with a focus predominantly on those based on measurement of immunity. A search was carried out to identify relevant papers meeting a pre-defined set of inclusion criteria. Forty-one papers were identified from this search, from which only twenty papers contained data to measure and compare diagnostic performance using diagnostic odds ratio. The diagnostic tests from each study were ranked based on sensitivity, specificity, and diagnostic odds ratio to define high performing tests. High sensitivity and specificity values across a range of species were reported for a new antigenic target, P22 complex, demonstrating it to be a reliable and accurate antigenic target. Since the last review of this kind was undertaken, the immunodiagnosis of TB in meerkats and African wild dogs was reported for the first time. Suid species showed the most consistent immunological responses and highlight a potential dichotomy between humoral and cellular immune responses." @default.
- W3161571428 created "2021-05-24" @default.
- W3161571428 creator A5000673193 @default.
- W3161571428 creator A5032045572 @default.
- W3161571428 date "2021-05-11" @default.
- W3161571428 modified "2023-09-26" @default.
- W3161571428 title "Review of Methods Used for Diagnosing Tuberculosis in Captive and Free-Ranging Non-Bovid Species (2012–2020)" @default.
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- W3161571428 doi "https://doi.org/10.3390/pathogens10050584" @default.
- W3161571428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8151627" @default.
- W3161571428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34064571" @default.
- W3161571428 hasPublicationYear "2021" @default.
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