Matches in SemOpenAlex for { <https://semopenalex.org/work/W3161610012> ?p ?o ?g. }
- W3161610012 abstract "Glucocorticoids are effective drugs for treating immune-related diseases, but prolonged therapy is associated with an increased risk of various infectious diseases, including tuberculosis. In this study, we have used a larval zebrafish model for tuberculosis, based on Mycobacterium marinum ( Mm ) infection, to study the effect of glucocorticoids. Our results show that the synthetic glucocorticoid beclomethasone increases the bacterial burden and the dissemination of a systemic Mm infection. The exacerbated Mm infection was associated with a decreased phagocytic activity of macrophages, higher percentages of extracellular bacteria, and a reduced rate of infected cell death, whereas the bactericidal capacity of the macrophages was not affected. The inhibited phagocytic capacity of macrophages was associated with suppression of the transcription of genes involved in phagocytosis in these cells. The decreased bacterial phagocytosis by macrophages was not specific for Mm , since it was also observed upon infection with Salmonella Typhimurium. In conclusion, our results show that glucocorticoids inhibit the phagocytic activity of macrophages, which may increase the severity of bacterial infections like tuberculosis." @default.
- W3161610012 created "2021-05-24" @default.
- W3161610012 creator A5011398750 @default.
- W3161610012 creator A5016605320 @default.
- W3161610012 creator A5022892166 @default.
- W3161610012 creator A5076985220 @default.
- W3161610012 date "2021-05-11" @default.
- W3161610012 modified "2023-09-28" @default.
- W3161610012 title "Glucocorticoid-Induced Exacerbation of Mycobacterial Infection Is Associated With a Reduced Phagocytic Capacity of Macrophages" @default.
- W3161610012 cites W1507444366 @default.
- W3161610012 cites W1544691147 @default.
- W3161610012 cites W1637790842 @default.
- W3161610012 cites W1640525409 @default.
- W3161610012 cites W1871506309 @default.
- W3161610012 cites W1891961100 @default.
- W3161610012 cites W1938351738 @default.
- W3161610012 cites W1968900414 @default.
- W3161610012 cites W1980353886 @default.
- W3161610012 cites W1986514504 @default.
- W3161610012 cites W1995018856 @default.
- W3161610012 cites W1995409834 @default.
- W3161610012 cites W2002815339 @default.
- W3161610012 cites W2004815652 @default.
- W3161610012 cites W2014406470 @default.
- W3161610012 cites W2014843809 @default.
- W3161610012 cites W2020069982 @default.
- W3161610012 cites W2020777797 @default.
- W3161610012 cites W2021336001 @default.
- W3161610012 cites W2024388233 @default.
- W3161610012 cites W2034408518 @default.
- W3161610012 cites W2042048278 @default.
- W3161610012 cites W2043149452 @default.
- W3161610012 cites W2043909105 @default.
- W3161610012 cites W2046288566 @default.
- W3161610012 cites W2050195517 @default.
- W3161610012 cites W2064964564 @default.
- W3161610012 cites W2067579914 @default.
- W3161610012 cites W2074373846 @default.
- W3161610012 cites W2074401088 @default.
- W3161610012 cites W2075400586 @default.
- W3161610012 cites W2079533675 @default.
- W3161610012 cites W2080308390 @default.
- W3161610012 cites W2084559325 @default.
- W3161610012 cites W2089248014 @default.
- W3161610012 cites W2095444661 @default.
- W3161610012 cites W2096768353 @default.
- W3161610012 cites W2098047948 @default.
- W3161610012 cites W2098709296 @default.
- W3161610012 cites W2099452097 @default.
- W3161610012 cites W2100088019 @default.
- W3161610012 cites W2101155558 @default.
- W3161610012 cites W2106942635 @default.
- W3161610012 cites W2113164220 @default.
- W3161610012 cites W2118636097 @default.
- W3161610012 cites W2119331335 @default.
- W3161610012 cites W2127676550 @default.
- W3161610012 cites W2128471563 @default.
- W3161610012 cites W2130821174 @default.
- W3161610012 cites W2140380746 @default.
- W3161610012 cites W2144639095 @default.
- W3161610012 cites W2145334570 @default.
- W3161610012 cites W2147520845 @default.
- W3161610012 cites W2150114897 @default.
- W3161610012 cites W2151667260 @default.
- W3161610012 cites W2155511376 @default.
- W3161610012 cites W2156420692 @default.
- W3161610012 cites W2157771094 @default.
- W3161610012 cites W2158014788 @default.
- W3161610012 cites W2159560463 @default.
- W3161610012 cites W2160408047 @default.
- W3161610012 cites W2163398312 @default.
- W3161610012 cites W2164474259 @default.
- W3161610012 cites W2165901898 @default.
- W3161610012 cites W2171433869 @default.
- W3161610012 cites W2184156621 @default.
- W3161610012 cites W2397464061 @default.
- W3161610012 cites W2406124884 @default.
- W3161610012 cites W2417627286 @default.
- W3161610012 cites W2418747985 @default.
- W3161610012 cites W2479197761 @default.
- W3161610012 cites W2533230523 @default.
- W3161610012 cites W2579472977 @default.
- W3161610012 cites W2602729299 @default.
- W3161610012 cites W2613487728 @default.
- W3161610012 cites W2649865612 @default.
- W3161610012 cites W2729366780 @default.
- W3161610012 cites W2752984482 @default.
- W3161610012 cites W2804280402 @default.
- W3161610012 cites W2884239386 @default.
- W3161610012 cites W2912054293 @default.
- W3161610012 cites W2912544720 @default.
- W3161610012 cites W2913840238 @default.
- W3161610012 cites W2927975467 @default.
- W3161610012 cites W2930925102 @default.
- W3161610012 cites W2952679984 @default.
- W3161610012 cites W2953413417 @default.
- W3161610012 cites W2968206736 @default.
- W3161610012 cites W2973256922 @default.
- W3161610012 cites W3144695097 @default.
- W3161610012 cites W4211157605 @default.