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- W3161622125 endingPage "118148" @default.
- W3161622125 startingPage "118148" @default.
- W3161622125 abstract "Resting-state studies have typically assumed constant functional connectivity (FC) between brain regions, and these parameters of interest provide meaningful descriptions of the functional organization of the brain. A number of studies have recently provided evidence pointing to dynamic FC fluctuations in the resting brain, especially in higher-order regions such as the default mode network (DMN). The neural activities underlying dynamic FC remain poorly understood. Here, we recorded electrophysiological signals from DMN regions in freely behaving rats. The dynamic FCs between signals within the DMN were estimated by the phase locking value (PLV) method with sliding time windows across vigilance states [quiet wakefulness (QW) and slow-wave and rapid eye movement sleep (SWS and REMS)]. Factor analysis was then performed to reveal the hidden patterns within the DMN. We identified distinct spatial FC patterns according to the similarities between their temporal dynamics. Interestingly, some of these patterns were vigilance state-dependent, while others were independent across states. The temporal contributions of these patterns fluctuated over time, and their interactive relationships were different across vigilance states. These spatial patterns with dynamic temporal contributions and combinations may offer a flexible framework for efficiently integrating information to support cognition and behavior. These findings provide novel insights into the dynamic functional organization of the rat DMN." @default.
- W3161622125 created "2021-05-24" @default.
- W3161622125 creator A5017427215 @default.
- W3161622125 creator A5018644308 @default.
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- W3161622125 creator A5052836448 @default.
- W3161622125 creator A5060431284 @default.
- W3161622125 creator A5069278482 @default.
- W3161622125 date "2021-08-01" @default.
- W3161622125 modified "2023-10-16" @default.
- W3161622125 title "State-independent and state-dependent patterns in the rat default mode network" @default.
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