Matches in SemOpenAlex for { <https://semopenalex.org/work/W3161703491> ?p ?o ?g. }
- W3161703491 endingPage "2989" @default.
- W3161703491 startingPage "2989" @default.
- W3161703491 abstract "The application of internal standards in quantitative and qualitative bioanalysis is a commonly used procedure. They are usually isotopically labeled analogs of the analyte, used in quantitative LC-MS analysis. Usually, 2H, 13C, 15N and 18O isotopes are used. The synthesis of deuterated isotopologues is relatively inexpensive, however, due to the isotopic effect of deuterium and the lack of isotopologue co-elution, usually they are not considered as good internal standards for LC-MS quantification. On the other hand, the preparation of 13C, 15N and 18O containing standards of drugs and their metabolites requires a complicated multistep de novo synthesis, starting from the isotopically labeled substrates, which are usually expensive. Therefore, there is a strong need for the development of low-cost methods for isotope-labeled standard preparations for quantitative analysis by LC-MS. The presented review concentrates on the preparation of deuterium-labeled standards by hydrogen−deuterium exchange reactions at the carbon centers. Recent advances in the development of the methods of isotopologues preparation and their application in quantitative analysis by LC-MS are evaluated." @default.
- W3161703491 created "2021-05-24" @default.
- W3161703491 creator A5018317661 @default.
- W3161703491 creator A5030804354 @default.
- W3161703491 date "2021-05-18" @default.
- W3161703491 modified "2023-10-14" @default.
- W3161703491 title "Trends in the Hydrogen−Deuterium Exchange at the Carbon Centers. Preparation of Internal Standards for Quantitative Analysis by LC-MS" @default.
- W3161703491 cites W1128039574 @default.
- W3161703491 cites W1495868850 @default.
- W3161703491 cites W1591129126 @default.
- W3161703491 cites W1839470390 @default.
- W3161703491 cites W1897380537 @default.
- W3161703491 cites W1969024152 @default.
- W3161703491 cites W1970192183 @default.
- W3161703491 cites W1972250745 @default.
- W3161703491 cites W1972986355 @default.
- W3161703491 cites W1973382484 @default.
- W3161703491 cites W1976199108 @default.
- W3161703491 cites W1976238935 @default.
- W3161703491 cites W1977780946 @default.
- W3161703491 cites W1978622520 @default.
- W3161703491 cites W1981719933 @default.
- W3161703491 cites W1985413466 @default.
- W3161703491 cites W1986609774 @default.
- W3161703491 cites W1992197622 @default.
- W3161703491 cites W2001084364 @default.
- W3161703491 cites W2001385996 @default.
- W3161703491 cites W2001429207 @default.
- W3161703491 cites W2001472155 @default.
- W3161703491 cites W2001644190 @default.
- W3161703491 cites W2004981069 @default.
- W3161703491 cites W2006810191 @default.
- W3161703491 cites W2007592675 @default.
- W3161703491 cites W2012007571 @default.
- W3161703491 cites W2013670057 @default.
- W3161703491 cites W2015841648 @default.
- W3161703491 cites W2016041661 @default.
- W3161703491 cites W2016742463 @default.
- W3161703491 cites W2017449102 @default.
- W3161703491 cites W2023284544 @default.
- W3161703491 cites W2024660488 @default.
- W3161703491 cites W2026501368 @default.
- W3161703491 cites W2029695172 @default.
- W3161703491 cites W2030530303 @default.
- W3161703491 cites W2030899902 @default.
- W3161703491 cites W2031904689 @default.
- W3161703491 cites W2033864574 @default.
- W3161703491 cites W2034265800 @default.
- W3161703491 cites W2035427755 @default.
- W3161703491 cites W2035439150 @default.
- W3161703491 cites W2039564712 @default.
- W3161703491 cites W2039853269 @default.
- W3161703491 cites W2040806801 @default.
- W3161703491 cites W2043145942 @default.
- W3161703491 cites W2046025972 @default.
- W3161703491 cites W2050571143 @default.
- W3161703491 cites W2051207804 @default.
- W3161703491 cites W2051813548 @default.
- W3161703491 cites W2052123065 @default.
- W3161703491 cites W2054663619 @default.
- W3161703491 cites W2055065542 @default.
- W3161703491 cites W2055916630 @default.
- W3161703491 cites W2060429325 @default.
- W3161703491 cites W2062048491 @default.
- W3161703491 cites W2063779779 @default.
- W3161703491 cites W2066123254 @default.
- W3161703491 cites W2067418044 @default.
- W3161703491 cites W2069037623 @default.
- W3161703491 cites W2070740853 @default.
- W3161703491 cites W2072184365 @default.
- W3161703491 cites W2076265513 @default.
- W3161703491 cites W2076355241 @default.
- W3161703491 cites W2078852350 @default.
- W3161703491 cites W2079055648 @default.
- W3161703491 cites W2080632083 @default.
- W3161703491 cites W2085595472 @default.
- W3161703491 cites W2086316530 @default.
- W3161703491 cites W2087457886 @default.
- W3161703491 cites W2087712963 @default.
- W3161703491 cites W2090903456 @default.
- W3161703491 cites W2095107862 @default.
- W3161703491 cites W2110332264 @default.
- W3161703491 cites W2110984352 @default.
- W3161703491 cites W2114320763 @default.
- W3161703491 cites W2116931633 @default.
- W3161703491 cites W2123285183 @default.
- W3161703491 cites W2125686834 @default.
- W3161703491 cites W2128595964 @default.
- W3161703491 cites W2135927499 @default.
- W3161703491 cites W2136738767 @default.
- W3161703491 cites W2138537900 @default.
- W3161703491 cites W2143175458 @default.
- W3161703491 cites W2146020529 @default.
- W3161703491 cites W2149968303 @default.
- W3161703491 cites W2159382796 @default.
- W3161703491 cites W2159721777 @default.
- W3161703491 cites W2169146772 @default.
- W3161703491 cites W2207376786 @default.