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• W3161739239 endingPage "106459" @default.
• W3161739239 startingPage "106459" @default.
• W3161739239 abstract "Breast cancer is the most commonly diagnosed type of cancer among women. For the last fifteen years, treatments that are less invasive than lumpectomy, such as high-intensity focused ultrasound (HIFU) therapy, have been developed, with encouraging results. In this study, a toroidal HIFU transducer was used to create lesions of at least 2 cm in diameter within less than one minute of treatment. The toroidal HIFU transducer created two focal zones that led to large, fast and homogeneous ablations (10.5 cc/min). The experiments were conducted in 30 human samples of normal breast tissues recovered from mastectomies to measure acoustic attenuation (N = 30), and then, HIFU lesions were created (N = 15). Eight HIFU ablations were performed to evaluate the reproducibility of the lesions. HIFU lesions were created in 45 s with a toroidal HIFU transducer working at 2.5 MHz. The longest and shortest axes of the HIFU lesions were 21.7 ± 3.1 mm and 23.5 ± 3.3 mm respectively, corresponding to an average volume of 7.3 ± 1.4 cm3. These HIFU lesions were performed at an average depth of 19.0 ± 1.5 mm, while the integrity of the skin was preserved. The HIFU-treated breast tissues had a higher level of attenuation (0.57 ± 0.11 Np.cm−1.MHz−1) when compared to the untreated tissues (0.21 ± 0.04 Np.cm−1.MHz−1). This study shows the feasibility of a fast and fully noninvasive treatment using a toroidal transducer for breast tumors measuring up to 15 mm in diameter." @default.
• W3161739239 created "2021-05-24" @default.
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• W3161739239 date "2021-08-01" @default.
• W3161739239 modified "2023-10-06" @default.
• W3161739239 title "Development of a noninvasive HIFU treatment for breast adenocarcinomas using a toroidal transducer based on preliminary attenuation measurements" @default.
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• W3161739239 doi "https://doi.org/10.1016/j.ultras.2021.106459" @default.
• W3161739239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33990009" @default.
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