Matches in SemOpenAlex for { <https://semopenalex.org/work/W3161804418> ?p ?o ?g. }
- W3161804418 endingPage "352" @default.
- W3161804418 startingPage "352" @default.
- W3161804418 abstract "This work demonstrates the effects of a newly synthesized conjugate of the plant triterpenoid betulin and the penetrating cation F16 used for mitochondrial targeting. The resulting F16-betulin conjugate revealed a mitochondria-targeted effect, decreasing the mitochondrial potential and inducing superoxide overproduction in rat thymocytes in vitro. It has been suggested that this may cause the cytotoxic effect of the conjugate, which significantly exceeds the effectiveness of its precursors, betulin and F16. Using isolated rat liver mitochondria, we found that the F16-betulin conjugate has a surface-active effect on mitochondrial membranes, causing organelle aggregation. This effect of the derivative resulted in a dose-dependent decrease in mitochondrial transmembrane potential, as well as suppression of respiration and oxidative phosphorylation, especially in the case of nicotinamide adenine dinucleotide (NAD)-fueled organelles. In addition, the F16-betulin conjugate caused an increase in H2O2 generation by mitochondria fueled with glutamate and malate. These effects of the derivative can presumably be due to the powerful suppression of the redox activity of complex I of the mitochondrial electron transport chain. The paper discusses how the mitochondria-targeted effects of the F16-betulin conjugate may be related to its cytotoxic effects." @default.
- W3161804418 created "2021-05-24" @default.
- W3161804418 creator A5010702981 @default.
- W3161804418 creator A5022118598 @default.
- W3161804418 creator A5037236045 @default.
- W3161804418 creator A5054531051 @default.
- W3161804418 creator A5062734581 @default.
- W3161804418 creator A5089252258 @default.
- W3161804418 date "2021-05-10" @default.
- W3161804418 modified "2023-10-03" @default.
- W3161804418 title "Effect of F16-Betulin Conjugate on Mitochondrial Membranes and Its Role in Cell Death Initiation" @default.
- W3161804418 cites W1215968885 @default.
- W3161804418 cites W1499289589 @default.
- W3161804418 cites W1748850585 @default.
- W3161804418 cites W2015794080 @default.
- W3161804418 cites W2036686104 @default.
- W3161804418 cites W2051476652 @default.
- W3161804418 cites W2052375464 @default.
- W3161804418 cites W2076413866 @default.
- W3161804418 cites W2076598575 @default.
- W3161804418 cites W2078002817 @default.
- W3161804418 cites W2087240393 @default.
- W3161804418 cites W2095004303 @default.
- W3161804418 cites W2101373754 @default.
- W3161804418 cites W2122691360 @default.
- W3161804418 cites W2155528804 @default.
- W3161804418 cites W2329658178 @default.
- W3161804418 cites W2496267438 @default.
- W3161804418 cites W2529595238 @default.
- W3161804418 cites W2554753461 @default.
- W3161804418 cites W2571130508 @default.
- W3161804418 cites W2711258373 @default.
- W3161804418 cites W2731789828 @default.
- W3161804418 cites W2744583332 @default.
- W3161804418 cites W2756354275 @default.
- W3161804418 cites W2803223949 @default.
- W3161804418 cites W2803687733 @default.
- W3161804418 cites W2890862022 @default.
- W3161804418 cites W2938766357 @default.
- W3161804418 cites W2950437836 @default.
- W3161804418 cites W3018159711 @default.
- W3161804418 cites W3018213314 @default.
- W3161804418 cites W3032917335 @default.
- W3161804418 cites W3044531785 @default.
- W3161804418 cites W3115257494 @default.
- W3161804418 cites W3119310506 @default.
- W3161804418 cites W3121947612 @default.
- W3161804418 cites W3149487008 @default.
- W3161804418 cites W4211182080 @default.
- W3161804418 doi "https://doi.org/10.3390/membranes11050352" @default.
- W3161804418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8151401" @default.
- W3161804418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34068772" @default.
- W3161804418 hasPublicationYear "2021" @default.
- W3161804418 type Work @default.
- W3161804418 sameAs 3161804418 @default.
- W3161804418 citedByCount "17" @default.
- W3161804418 countsByYear W31618044182021 @default.
- W3161804418 countsByYear W31618044182022 @default.
- W3161804418 countsByYear W31618044182023 @default.
- W3161804418 crossrefType "journal-article" @default.
- W3161804418 hasAuthorship W3161804418A5010702981 @default.
- W3161804418 hasAuthorship W3161804418A5022118598 @default.
- W3161804418 hasAuthorship W3161804418A5037236045 @default.
- W3161804418 hasAuthorship W3161804418A5054531051 @default.
- W3161804418 hasAuthorship W3161804418A5062734581 @default.
- W3161804418 hasAuthorship W3161804418A5089252258 @default.
- W3161804418 hasBestOaLocation W31618044181 @default.
- W3161804418 hasConcept C12554922 @default.
- W3161804418 hasConcept C134306372 @default.
- W3161804418 hasConcept C181199279 @default.
- W3161804418 hasConcept C181911157 @default.
- W3161804418 hasConcept C185592680 @default.
- W3161804418 hasConcept C197336794 @default.
- W3161804418 hasConcept C2778509883 @default.
- W3161804418 hasConcept C28859421 @default.
- W3161804418 hasConcept C33923547 @default.
- W3161804418 hasConcept C55493867 @default.
- W3161804418 hasConcept C57600042 @default.
- W3161804418 hasConcept C75520062 @default.
- W3161804418 hasConcept C86803240 @default.
- W3161804418 hasConcept C95444343 @default.
- W3161804418 hasConceptScore W3161804418C12554922 @default.
- W3161804418 hasConceptScore W3161804418C134306372 @default.
- W3161804418 hasConceptScore W3161804418C181199279 @default.
- W3161804418 hasConceptScore W3161804418C181911157 @default.
- W3161804418 hasConceptScore W3161804418C185592680 @default.
- W3161804418 hasConceptScore W3161804418C197336794 @default.
- W3161804418 hasConceptScore W3161804418C2778509883 @default.
- W3161804418 hasConceptScore W3161804418C28859421 @default.
- W3161804418 hasConceptScore W3161804418C33923547 @default.
- W3161804418 hasConceptScore W3161804418C55493867 @default.
- W3161804418 hasConceptScore W3161804418C57600042 @default.
- W3161804418 hasConceptScore W3161804418C75520062 @default.
- W3161804418 hasConceptScore W3161804418C86803240 @default.
- W3161804418 hasConceptScore W3161804418C95444343 @default.
- W3161804418 hasFunder F4320321079 @default.
- W3161804418 hasFunder F4320324099 @default.
- W3161804418 hasIssue "5" @default.