Matches in SemOpenAlex for { <https://semopenalex.org/work/W3161871823> ?p ?o ?g. }
- W3161871823 abstract "New thiazolidine-2,4-dione hybrids were designed and synthesized as potential peroxisome proliferator-activated receptor (PPAR)-γ agonists and thymidylate synthase inhibitors. All the synthesized compounds follow Lipinski's and Veber's rules and possess the desired pharmacokinetics properties. The PPAR-γ transactivation results displayed that compounds 12 (78.9%) and 11 (73.4%) were the most active compounds and they increased PPAR-γ gene expression by 2.2- and 2.4-fold, respectively. Compounds 12, 11, and 8 showed promising cytotoxicity, with IC50 values ranging from 1.4 to 4.5 μM against MCF-7 cells and from 1.8 to 8.4 μM against HCT-116 cells. Compounds 11 and 12 also inhibited thymidylate synthase with IC50 values of 5.1 and 3.2 μM, respectively, confirming their mode of action as thymidylate synthase inhibitors. Finally, molecular docking studies supported the in vitro biological activity results." @default.
- W3161871823 created "2021-05-24" @default.
- W3161871823 creator A5000949596 @default.
- W3161871823 date "2021-05-14" @default.
- W3161871823 modified "2023-10-12" @default.
- W3161871823 title "Design, synthesis, and molecular docking studies of thiazolidinediones as PPAR‐γ agonists and thymidylate synthase inhibitors" @default.
- W3161871823 cites W1508681581 @default.
- W3161871823 cites W1948556242 @default.
- W3161871823 cites W1985588649 @default.
- W3161871823 cites W2027446106 @default.
- W3161871823 cites W2033514426 @default.
- W3161871823 cites W2037152158 @default.
- W3161871823 cites W2043912903 @default.
- W3161871823 cites W2055642631 @default.
- W3161871823 cites W2059945861 @default.
- W3161871823 cites W2078757355 @default.
- W3161871823 cites W2086940425 @default.
- W3161871823 cites W2102510698 @default.
- W3161871823 cites W2105649494 @default.
- W3161871823 cites W2105743205 @default.
- W3161871823 cites W2107333702 @default.
- W3161871823 cites W2120265871 @default.
- W3161871823 cites W2135732933 @default.
- W3161871823 cites W2143808884 @default.
- W3161871823 cites W2169303908 @default.
- W3161871823 cites W2396930286 @default.
- W3161871823 cites W2409522603 @default.
- W3161871823 cites W2560851361 @default.
- W3161871823 cites W2598125535 @default.
- W3161871823 cites W2755756968 @default.
- W3161871823 cites W2759006960 @default.
- W3161871823 cites W2761380851 @default.
- W3161871823 cites W2904975250 @default.
- W3161871823 cites W2930899603 @default.
- W3161871823 cites W2972818614 @default.
- W3161871823 cites W2990309084 @default.
- W3161871823 cites W2996223596 @default.
- W3161871823 cites W2998693199 @default.
- W3161871823 cites W3003198583 @default.
- W3161871823 cites W3020893404 @default.
- W3161871823 cites W3024956451 @default.
- W3161871823 cites W3048963168 @default.
- W3161871823 cites W3081006910 @default.
- W3161871823 cites W3087042199 @default.
- W3161871823 cites W3104581305 @default.
- W3161871823 cites W4255677297 @default.
- W3161871823 doi "https://doi.org/10.1002/ardp.202100021" @default.
- W3161871823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33988883" @default.
- W3161871823 hasPublicationYear "2021" @default.
- W3161871823 type Work @default.
- W3161871823 sameAs 3161871823 @default.
- W3161871823 citedByCount "9" @default.
- W3161871823 countsByYear W31618718232021 @default.
- W3161871823 countsByYear W31618718232022 @default.
- W3161871823 crossrefType "journal-article" @default.
- W3161871823 hasAuthorship W3161871823A5000949596 @default.
- W3161871823 hasConcept C104317684 @default.
- W3161871823 hasConcept C109316439 @default.
- W3161871823 hasConcept C123321153 @default.
- W3161871823 hasConcept C1292079 @default.
- W3161871823 hasConcept C150194340 @default.
- W3161871823 hasConcept C159110408 @default.
- W3161871823 hasConcept C181199279 @default.
- W3161871823 hasConcept C185592680 @default.
- W3161871823 hasConcept C202751555 @default.
- W3161871823 hasConcept C2776694085 @default.
- W3161871823 hasConcept C2777752497 @default.
- W3161871823 hasConcept C2780456651 @default.
- W3161871823 hasConcept C41685203 @default.
- W3161871823 hasConcept C54355233 @default.
- W3161871823 hasConcept C55493867 @default.
- W3161871823 hasConcept C71240020 @default.
- W3161871823 hasConcept C71924100 @default.
- W3161871823 hasConcept C86803240 @default.
- W3161871823 hasConcept C98274493 @default.
- W3161871823 hasConceptScore W3161871823C104317684 @default.
- W3161871823 hasConceptScore W3161871823C109316439 @default.
- W3161871823 hasConceptScore W3161871823C123321153 @default.
- W3161871823 hasConceptScore W3161871823C1292079 @default.
- W3161871823 hasConceptScore W3161871823C150194340 @default.
- W3161871823 hasConceptScore W3161871823C159110408 @default.
- W3161871823 hasConceptScore W3161871823C181199279 @default.
- W3161871823 hasConceptScore W3161871823C185592680 @default.
- W3161871823 hasConceptScore W3161871823C202751555 @default.
- W3161871823 hasConceptScore W3161871823C2776694085 @default.
- W3161871823 hasConceptScore W3161871823C2777752497 @default.
- W3161871823 hasConceptScore W3161871823C2780456651 @default.
- W3161871823 hasConceptScore W3161871823C41685203 @default.
- W3161871823 hasConceptScore W3161871823C54355233 @default.
- W3161871823 hasConceptScore W3161871823C55493867 @default.
- W3161871823 hasConceptScore W3161871823C71240020 @default.
- W3161871823 hasConceptScore W3161871823C71924100 @default.
- W3161871823 hasConceptScore W3161871823C86803240 @default.
- W3161871823 hasConceptScore W3161871823C98274493 @default.
- W3161871823 hasIssue "9" @default.
- W3161871823 hasLocation W31618718231 @default.
- W3161871823 hasLocation W31618718232 @default.
- W3161871823 hasOpenAccess W3161871823 @default.
- W3161871823 hasPrimaryLocation W31618718231 @default.
- W3161871823 hasRelatedWork W1984994946 @default.