FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3162017384> ?p ?o ?g. }

• W3162017384 abstract "Low skeletal muscle capillarization is associated with impaired glucose tolerance (IGT); however, aerobic exercise training with weight loss (AEX + WL) increases skeletal muscle capillarization and improves glucose tolerance in adults with IGT. Given that the expression of angiogenic growth factors mediates skeletal muscle capillarization, we sought to determine whether angiogenic growth factor levels are associated with low capillarization in those with IGT versus normal glucose tolerance (NGT) or to the benefits of AEX + WL in both groups. Sixteen overweight or obese men 50-75 yr of age completed 6 mo of AEX + WL with oral glucose tolerance tests and vastus lateralis muscle biopsies for measurement of muscle vascular endothelial growth factor (VEGF), placental growth factor (PlGF), soluble fms-like tyrosine kinase receptor-1 (sFlt-1), and basic fibroblast growth factor (bFGF). At baseline, all growth factor levels were numerically lower in IGT than NGT, but these did not reach statistical significance (P = 0.06-0.33). Following AEX + WL, aerobic capacity [maximal oxygen consumption (V̇o2max)] increased by 16%, whereas body weight and 120-min postprandial glucose levels decreased by 10% and 15%, respectively (P ≤ 0.001 for all). There was a main effect of AEX + WL to increase VEGF (0.095 ± 0.016 vs. 0.114 ± 0.018 ng/µg, P < 0.05), PlGF (0.004 ± 0.001 vs. 0.005 ± 0.001 ng/µg, P < 0.05), and sFlt-1 (0.216 ± 0.029 vs. 0.264 ± 0.036 ng/µg, P < 0.01), with overall increases driven by the IGT group. These results suggest that 6 mo of AEX + WL increases skeletal muscle angiogenic growth factor levels in obese older adults with IGT and NGT, which may contribute to our previous findings that AEX + WL increases capillarization to improve glucose tolerance in those with IGT.NEW & NOTEWORTHY Skeletal muscle capillarization is lower in adults with impaired glucose tolerance than normal controls. This may, in part, be attributable to differential expression of angiogenic growth factors in skeletal muscle. Using a 6-mo aerobic exercise intervention with ∼10% body weight loss (AEX + WL), we show that the expression of angiogenic growth factors tends to be lower in adults with impaired glucose tolerance compared with normal controls and that AEX + WL increased expression of angiogenic growth factors in all participants." @default.
• W3162017384 created "2021-05-24" @default.
• W3162017384 creator A5004497797 @default.
• W3162017384 creator A5023927508 @default.
• W3162017384 creator A5033223907 @default.
• W3162017384 creator A5040656972 @default.
• W3162017384 creator A5085164642 @default.
• W3162017384 date "2021-05-20" @default.
• W3162017384 modified "2023-09-27" @default.
• W3162017384 title "Effects of exercise training with weight loss on skeletal muscle expression of angiogenic factors in overweight and obese older men" @default.
• W3162017384 cites W1567632829 @default.
• W3162017384 cites W1587020653 @default.
• W3162017384 cites W1837216780 @default.
• W3162017384 cites W1875554126 @default.
• W3162017384 cites W1964609274 @default.
• W3162017384 cites W1964717422 @default.
• W3162017384 cites W1979790422 @default.
• W3162017384 cites W1986469266 @default.
• W3162017384 cites W1991581009 @default.
• W3162017384 cites W1993926354 @default.
• W3162017384 cites W2002201877 @default.
• W3162017384 cites W2020669560 @default.
• W3162017384 cites W2023918862 @default.
• W3162017384 cites W2031836893 @default.
• W3162017384 cites W2039222035 @default.
• W3162017384 cites W2050922085 @default.
• W3162017384 cites W2051268134 @default.
• W3162017384 cites W2060302807 @default.
• W3162017384 cites W2066607311 @default.
• W3162017384 cites W2070655502 @default.
• W3162017384 cites W2076601545 @default.
• W3162017384 cites W2085061661 @default.
• W3162017384 cites W2090039999 @default.
• W3162017384 cites W2097881605 @default.
• W3162017384 cites W2102307663 @default.
• W3162017384 cites W2110357733 @default.
• W3162017384 cites W2114135748 @default.
• W3162017384 cites W2117147465 @default.
• W3162017384 cites W2119112373 @default.
• W3162017384 cites W2130780675 @default.
• W3162017384 cites W2135344167 @default.
• W3162017384 cites W2138441948 @default.
• W3162017384 cites W2138454311 @default.
• W3162017384 cites W2141670098 @default.
• W3162017384 cites W2147920255 @default.
• W3162017384 cites W2150308167 @default.
• W3162017384 cites W2153461920 @default.
• W3162017384 cites W2155918372 @default.
• W3162017384 cites W2158822657 @default.
• W3162017384 cites W2167903736 @default.
• W3162017384 cites W2178693631 @default.
• W3162017384 cites W2184946669 @default.
• W3162017384 cites W2229261006 @default.
• W3162017384 cites W2332951586 @default.
• W3162017384 cites W2398773735 @default.
• W3162017384 cites W24674184 @default.
• W3162017384 cites W2728632316 @default.
• W3162017384 cites W2968449085 @default.
• W3162017384 cites W4251966062 @default.
• W3162017384 doi "https://doi.org/10.1152/japplphysiol.00084.2021" @default.
• W3162017384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8325618" @default.
• W3162017384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34013746" @default.
• W3162017384 hasPublicationYear "2021" @default.
• W3162017384 type Work @default.
• W3162017384 sameAs 3162017384 @default.
• W3162017384 citedByCount "2" @default.
• W3162017384 countsByYear W31620173842021 @default.
• W3162017384 countsByYear W31620173842022 @default.
• W3162017384 crossrefType "journal-article" @default.
• W3162017384 hasAuthorship W3162017384A5004497797 @default.
• W3162017384 hasAuthorship W3162017384A5023927508 @default.
• W3162017384 hasAuthorship W3162017384A5033223907 @default.
• W3162017384 hasAuthorship W3162017384A5040656972 @default.
• W3162017384 hasAuthorship W3162017384A5085164642 @default.
• W3162017384 hasBestOaLocation W31620173842 @default.
• W3162017384 hasConcept C126322002 @default.
• W3162017384 hasConcept C134018914 @default.
• W3162017384 hasConcept C167734588 @default.
• W3162017384 hasConcept C2777025900 @default.
• W3162017384 hasConcept C2777391703 @default.
• W3162017384 hasConcept C2778199505 @default.
• W3162017384 hasConcept C2779959927 @default.
• W3162017384 hasConcept C2780586474 @default.
• W3162017384 hasConcept C2780609358 @default.
• W3162017384 hasConcept C2780833929 @default.
• W3162017384 hasConcept C511355011 @default.
• W3162017384 hasConcept C555293320 @default.
• W3162017384 hasConcept C71924100 @default.
• W3162017384 hasConceptScore W3162017384C126322002 @default.
• W3162017384 hasConceptScore W3162017384C134018914 @default.
• W3162017384 hasConceptScore W3162017384C167734588 @default.
• W3162017384 hasConceptScore W3162017384C2777025900 @default.
• W3162017384 hasConceptScore W3162017384C2777391703 @default.
• W3162017384 hasConceptScore W3162017384C2778199505 @default.
• W3162017384 hasConceptScore W3162017384C2779959927 @default.
• W3162017384 hasConceptScore W3162017384C2780586474 @default.
• W3162017384 hasConceptScore W3162017384C2780609358 @default.
• W3162017384 hasConceptScore W3162017384C2780833929 @default.
• W3162017384 hasConceptScore W3162017384C511355011 @default.
• W3162017384 hasConceptScore W3162017384C555293320 @default.

• next