Matches in SemOpenAlex for { <https://semopenalex.org/work/W3162024937> ?p ?o ?g. }
- W3162024937 endingPage "1351" @default.
- W3162024937 startingPage "1284" @default.
- W3162024937 abstract "Crystallization of 204 kg of final active pharmaceutical ingredient was accomplished continuously using a cascade of mixed suspension mixed product removal crystallizers in cGMP manufacturing. This article describes the journey taken to transform a set of technical to final batch crystallizations into a continuous, combined cooling and antisolvent crystallization using three stirred tank crystallizers in series. Conversion of the batch process to a continuous process was beneficial to kinetically purge a key impurity. The conversion also allowed for the direct integration of the crystallization process with upstream continuous chemistry sections. A robust control strategy was developed from early research scale all the way to cGMP manufacturing. The authors will share the tools, techniques, modeling, and equipment used and challenges overcome to ensure a safe and reliable manufacturing process. A new intermittent flow technique transferred hot solution from a continuous evaporator into the first crystallizer with no solids bearding at the end of the inlet tubing. The continuous distillation, crystallization, and slurry-off filters were a key part of a broader continuous process and new building that won an International Society for Pharmaceutical Engineering 2019 Facility of the Year Award for Innovation." @default.
- W3162024937 created "2021-05-24" @default.
- W3162024937 creator A5006297503 @default.
- W3162024937 creator A5007056673 @default.
- W3162024937 creator A5008104303 @default.
- W3162024937 creator A5023687476 @default.
- W3162024937 creator A5036300878 @default.
- W3162024937 creator A5047216683 @default.
- W3162024937 creator A5049954144 @default.
- W3162024937 creator A5059349233 @default.
- W3162024937 creator A5064013767 @default.
- W3162024937 creator A5065155754 @default.
- W3162024937 creator A5068206594 @default.
- W3162024937 creator A5080835615 @default.
- W3162024937 creator A5083305448 @default.
- W3162024937 creator A5084166196 @default.
- W3162024937 creator A5086481625 @default.
- W3162024937 creator A5088975833 @default.
- W3162024937 date "2021-05-16" @default.
- W3162024937 modified "2023-10-03" @default.
- W3162024937 title "API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing" @default.
- W3162024937 cites W1530067823 @default.
- W3162024937 cites W1963885647 @default.
- W3162024937 cites W1975155173 @default.
- W3162024937 cites W1975260358 @default.
- W3162024937 cites W1975529164 @default.
- W3162024937 cites W1976692166 @default.
- W3162024937 cites W1981507209 @default.
- W3162024937 cites W1992075296 @default.
- W3162024937 cites W2001032983 @default.
- W3162024937 cites W2008250389 @default.
- W3162024937 cites W2012492422 @default.
- W3162024937 cites W2036082779 @default.
- W3162024937 cites W2050269368 @default.
- W3162024937 cites W2055172914 @default.
- W3162024937 cites W2055287364 @default.
- W3162024937 cites W2055753051 @default.
- W3162024937 cites W2057465660 @default.
- W3162024937 cites W2061179888 @default.
- W3162024937 cites W2065550282 @default.
- W3162024937 cites W2081244403 @default.
- W3162024937 cites W2092996449 @default.
- W3162024937 cites W2112211764 @default.
- W3162024937 cites W2158217599 @default.
- W3162024937 cites W2215963070 @default.
- W3162024937 cites W2278771383 @default.
- W3162024937 cites W2286617896 @default.
- W3162024937 cites W2316028778 @default.
- W3162024937 cites W2316099892 @default.
- W3162024937 cites W2317500619 @default.
- W3162024937 cites W2320816278 @default.
- W3162024937 cites W2322156480 @default.
- W3162024937 cites W2322458334 @default.
- W3162024937 cites W2325274076 @default.
- W3162024937 cites W2326210119 @default.
- W3162024937 cites W2327370278 @default.
- W3162024937 cites W2331545233 @default.
- W3162024937 cites W2334766701 @default.
- W3162024937 cites W2424517262 @default.
- W3162024937 cites W2470943470 @default.
- W3162024937 cites W2497200850 @default.
- W3162024937 cites W2511348188 @default.
- W3162024937 cites W2512068446 @default.
- W3162024937 cites W2516361293 @default.
- W3162024937 cites W2573988657 @default.
- W3162024937 cites W2595744132 @default.
- W3162024937 cites W2625140532 @default.
- W3162024937 cites W2626499280 @default.
- W3162024937 cites W2724438861 @default.
- W3162024937 cites W2738459753 @default.
- W3162024937 cites W2789411438 @default.
- W3162024937 cites W2806610993 @default.
- W3162024937 cites W2908735786 @default.
- W3162024937 cites W2909221052 @default.
- W3162024937 cites W2913208782 @default.
- W3162024937 cites W2920933640 @default.
- W3162024937 cites W2921034967 @default.
- W3162024937 cites W2921484436 @default.
- W3162024937 cites W2944350700 @default.
- W3162024937 cites W2969159253 @default.
- W3162024937 cites W2986254079 @default.
- W3162024937 cites W2993244335 @default.
- W3162024937 cites W3014364308 @default.
- W3162024937 cites W3034945845 @default.
- W3162024937 cites W4252929690 @default.
- W3162024937 cites W4286482534 @default.
- W3162024937 cites W95574922 @default.
- W3162024937 doi "https://doi.org/10.1021/acs.oprd.0c00345" @default.
- W3162024937 hasPublicationYear "2021" @default.
- W3162024937 type Work @default.
- W3162024937 sameAs 3162024937 @default.
- W3162024937 citedByCount "16" @default.
- W3162024937 countsByYear W31620249372021 @default.
- W3162024937 countsByYear W31620249372022 @default.
- W3162024937 countsByYear W31620249372023 @default.
- W3162024937 crossrefType "journal-article" @default.
- W3162024937 hasAuthorship W3162024937A5006297503 @default.
- W3162024937 hasAuthorship W3162024937A5007056673 @default.