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- W3162028011 endingPage "56" @default.
- W3162028011 startingPage "56" @default.
- W3162028011 abstract "Cardiovascular development is a complex process that starts with the formation of symmetrically located precardiac mesodermal precursors soon after gastrulation and is completed with the formation of a four-chambered heart with distinct inlet and outlet connections. Multiple transcriptional inputs are required to provide adequate regional identity to the forming atrial and ventricular chambers as well as their flanking regions; i.e., inflow tract, atrioventricular canal, and outflow tract. In this context, regional chamber identity is widely governed by regional activation of distinct T-box family members. Over the last decade, novel layers of gene regulatory mechanisms have been discovered with the identification of non-coding RNAs. microRNAs represent the most well-studied subcategory among short non-coding RNAs. In this study, we sought to investigate the functional role of distinct microRNAs that are predicted to target T-box family members. Our data demonstrated a highly dynamic expression of distinct microRNAs and T-box family members during cardiogenesis, revealing a relatively large subset of complementary and similar microRNA–mRNA expression profiles. Over-expression analyses demonstrated that a given microRNA can distinctly regulate the same T-box family member in distinct cardiac regions and within distinct temporal frameworks, supporting the notion of indirect regulatory mechanisms, and dual luciferase assays on Tbx2, Tbx3 and Tbx5 3′ UTR further supported this notion. Overall, our data demonstrated a highly dynamic microRNA and T-box family members expression during cardiogenesis and supported the notion that such microRNAs indirectly regulate the T-box family members in a tissue- and time-dependent manner." @default.
- W3162028011 created "2021-05-24" @default.
- W3162028011 creator A5003338755 @default.
- W3162028011 creator A5041465463 @default.
- W3162028011 creator A5049579719 @default.
- W3162028011 creator A5050514879 @default.
- W3162028011 creator A5076566076 @default.
- W3162028011 creator A5081010221 @default.
- W3162028011 creator A5087494268 @default.
- W3162028011 date "2021-05-14" @default.
- W3162028011 modified "2023-09-23" @default.
- W3162028011 title "Differential Spatio-Temporal Regulation of T-Box Gene Expression by microRNAs during Cardiac Development" @default.
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