Matches in SemOpenAlex for { <https://semopenalex.org/work/W3162030608> ?p ?o ?g. }
- W3162030608 abstract "Epigenetics studies heritable genomic modifications that occur with the participation of epigenetic modifying enzymes but without alterations of the nucleotide structure. Small-molecule inhibitors of these epigenetic modifying enzymes are known as epigenetic drugs (epi-drugs), which can cause programmed death of tumor cells by affecting the cell cycle, angiogenesis, proliferation, and migration. Epi-drugs include histone methylation inhibitors, histone demethylation inhibitors, histone deacetylation inhibitors, and DNA methylation inhibitors. Currently, epi-drugs undergo extensive development, research, and application. Although epi-drugs have convincing anti-tumor effects, the patient's sensitivity to epi-drug application is also a fundamental clinical issue. The development and research of biomarkers for epi-drugs provide a promising direction for screening drug-sensitive patients. Here, we review the predictive biomarkers of 12 epi-drugs as well as the progress of combination therapy with chemotherapeutic drugs or immunotherapy. Further, we discuss the improvement in the development of natural ingredients with low toxicity and low side effects as epi-drugs." @default.
- W3162030608 created "2021-05-24" @default.
- W3162030608 creator A5003642180 @default.
- W3162030608 creator A5043354763 @default.
- W3162030608 creator A5063852876 @default.
- W3162030608 date "2021-05-17" @default.
- W3162030608 modified "2023-10-17" @default.
- W3162030608 title "Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy" @default.
- W3162030608 cites W1603797292 @default.
- W3162030608 cites W1889748947 @default.
- W3162030608 cites W1893402990 @default.
- W3162030608 cites W1904095165 @default.
- W3162030608 cites W1967251674 @default.
- W3162030608 cites W1982529039 @default.
- W3162030608 cites W1989040039 @default.
- W3162030608 cites W2004380688 @default.
- W3162030608 cites W2008887283 @default.
- W3162030608 cites W2010407535 @default.
- W3162030608 cites W2022222857 @default.
- W3162030608 cites W2026111799 @default.
- W3162030608 cites W2030346979 @default.
- W3162030608 cites W2036230897 @default.
- W3162030608 cites W2044570206 @default.
- W3162030608 cites W2060597720 @default.
- W3162030608 cites W2060745052 @default.
- W3162030608 cites W2062838782 @default.
- W3162030608 cites W2068351971 @default.
- W3162030608 cites W2080509529 @default.
- W3162030608 cites W2084790890 @default.
- W3162030608 cites W2086492419 @default.
- W3162030608 cites W2102376919 @default.
- W3162030608 cites W2112004353 @default.
- W3162030608 cites W2127913359 @default.
- W3162030608 cites W2130157550 @default.
- W3162030608 cites W2132310381 @default.
- W3162030608 cites W2136474966 @default.
- W3162030608 cites W2143570904 @default.
- W3162030608 cites W2154083086 @default.
- W3162030608 cites W2156078931 @default.
- W3162030608 cites W2158485926 @default.
- W3162030608 cites W2169012257 @default.
- W3162030608 cites W2202764763 @default.
- W3162030608 cites W2319876601 @default.
- W3162030608 cites W2322316999 @default.
- W3162030608 cites W2486305727 @default.
- W3162030608 cites W2516412319 @default.
- W3162030608 cites W2571354525 @default.
- W3162030608 cites W2578822114 @default.
- W3162030608 cites W2588292471 @default.
- W3162030608 cites W2593436234 @default.
- W3162030608 cites W2599587525 @default.
- W3162030608 cites W2611004920 @default.
- W3162030608 cites W2761766860 @default.
- W3162030608 cites W2775617137 @default.
- W3162030608 cites W2790566984 @default.
- W3162030608 cites W2794110182 @default.
- W3162030608 cites W2799720186 @default.
- W3162030608 cites W2800647072 @default.
- W3162030608 cites W2807710457 @default.
- W3162030608 cites W2809383929 @default.
- W3162030608 cites W2895785343 @default.
- W3162030608 cites W2897972879 @default.
- W3162030608 cites W2899412336 @default.
- W3162030608 cites W2899763738 @default.
- W3162030608 cites W2900644235 @default.
- W3162030608 cites W2901028504 @default.
- W3162030608 cites W2902164076 @default.
- W3162030608 cites W2912254343 @default.
- W3162030608 cites W2922176925 @default.
- W3162030608 cites W2944025429 @default.
- W3162030608 cites W2945267900 @default.
- W3162030608 cites W2949451543 @default.
- W3162030608 cites W2958425042 @default.
- W3162030608 cites W2962507015 @default.
- W3162030608 cites W2969606677 @default.
- W3162030608 cites W2970548174 @default.
- W3162030608 cites W2970734757 @default.
- W3162030608 cites W2975888204 @default.
- W3162030608 cites W2980438467 @default.
- W3162030608 cites W2986264450 @default.
- W3162030608 cites W2991108194 @default.
- W3162030608 cites W2994046320 @default.
- W3162030608 cites W2994850615 @default.
- W3162030608 cites W3003928586 @default.
- W3162030608 cites W3006513842 @default.
- W3162030608 cites W3007027618 @default.
- W3162030608 cites W3008820509 @default.
- W3162030608 cites W3010095701 @default.
- W3162030608 cites W3011290602 @default.
- W3162030608 cites W3013714415 @default.
- W3162030608 cites W3022403689 @default.
- W3162030608 cites W3035213460 @default.
- W3162030608 cites W3037379642 @default.
- W3162030608 cites W3038942960 @default.
- W3162030608 cites W3042107687 @default.
- W3162030608 cites W3042535930 @default.
- W3162030608 cites W3043438918 @default.
- W3162030608 cites W3044347277 @default.
- W3162030608 cites W3044905603 @default.
- W3162030608 cites W3045753156 @default.