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• W3162065141 endingPage "493" @default.
• W3162065141 startingPage "493" @default.
• W3162065141 abstract "The objective of this article was to conduct a systematic review of the literature to contrast the existing evidence regarding the relationship between periodontal disease (PD) and diabetes mellitus (DM) with the possibly increased risk of SARS-CoV-2 infection, as well as to establish a hypothesis that explains the ways in which this interaction could take place. A literature search up from 1 January 2020 to 21 March 2021 was conducted in three electronic databases, namely, PubMed, Web of Science, and Scopus, in order to identify studies on periodontal disease alone or in conjunction with diabetes mellitus, reporting any relation with SARS-CoV-2 infection as a primary outcome. Only articles published in the English language were included. Due to the lack of studies, we decided to collect all the theoretical and clinical evidence suggesting a possible biological pathway evidencing the relationship among PD, DM, and SARS-CoV-2 infection. From a total of 29 articles, 12 were included for final review studies (five reviews, two hypotheses, one Special Issue, one perspective, one commentary, one case–control study, and one case report). In addition, this systematic review article hypothesizes the correlation between PD and type 2 diabetes mellitus (T2DM) by expression of angiotensin-converting enzyme 2 (ACE2) in periodontal tissue and the risk of SARS-CoV-2 infection. T2DM is a metabolic disorder characterized by high blood glucose levels resulting from altered insulin secretion or action. Likewise, periodontitis and T2DM are inflammatory disorders with a bidirectional association, and both diseases have a similar immunomodulatory cascade and cytokine profile. ACE2 is a crucial component of the renin–angiotensin system (RAS) and the key factor of entry in the cells by the new SARS-CoV-2. ACE2 is widely distributed in the lung and kidneys, and interestingly has a great distribution in the oral cavity, principally in the tongue and periodontal tissue. ACE2 in periodontal tissue plays a crucial role between health and disease. Moreover, the ACE2/Ang-(1-7)/MasR axis is downregulated in the dysbiotic and inflammatory periodontal environment. Nevertheless, the balance of ACE2 activity is modified in the context of concurrent diabetes, increasing the expression of ACE2 by the uncontrolled glycemia chronic in T2DM. Therefore, the uncontrolled hyperglycemia possibly increases the risk of developing periodontitis and triggering overexpression of ACE2 in periodontal tissue of T2DM patients, with these events potentially being essential to SARS-CoV-2 infection and the development of mild-to-severe form of COVID-19. In this sense, we would like to point out that the need for randomized controlled trials is imperative to support this association." @default.
• W3162065141 created "2021-05-24" @default.
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• W3162065141 date "2021-05-13" @default.
• W3162065141 modified "2023-10-18" @default.
• W3162065141 title "Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis" @default.
• W3162065141 cites W1917963654 @default.
• W3162065141 cites W1985115922 @default.
• W3162065141 cites W1989925586 @default.
• W3162065141 cites W2001482654 @default.
• W3162065141 cites W2024186757 @default.
• W3162065141 cites W2040416968 @default.
• W3162065141 cites W2054112982 @default.
• W3162065141 cites W2074291644 @default.
• W3162065141 cites W2075720836 @default.
• W3162065141 cites W2098679715 @default.
• W3162065141 cites W2105677438 @default.
• W3162065141 cites W2105708175 @default.
• W3162065141 cites W2112387463 @default.
• W3162065141 cites W2118808999 @default.
• W3162065141 cites W2134071881 @default.
• W3162065141 cites W2147854986 @default.
• W3162065141 cites W2152329221 @default.
• W3162065141 cites W2167384912 @default.
• W3162065141 cites W2168138251 @default.
• W3162065141 cites W2344306919 @default.
• W3162065141 cites W2426693543 @default.
• W3162065141 cites W2584540405 @default.
• W3162065141 cites W2767392813 @default.
• W3162065141 cites W2809600205 @default.
• W3162065141 cites W2914960271 @default.
• W3162065141 cites W2922577842 @default.
• W3162065141 cites W2955279955 @default.
• W3162065141 cites W2962815603 @default.
• W3162065141 cites W2969278272 @default.
• W3162065141 cites W2981215266 @default.
• W3162065141 cites W2991960071 @default.
• W3162065141 cites W2997389796 @default.
• W3162065141 cites W3001342260 @default.
• W3162065141 cites W3005655936 @default.
• W3162065141 cites W3008295344 @default.
• W3162065141 cites W3009281076 @default.
• W3162065141 cites W3009656198 @default.
• W3162065141 cites W3009802696 @default.
• W3162065141 cites W3009912996 @default.
• W3162065141 cites W3010325168 @default.
• W3162065141 cites W3010763499 @default.
• W3162065141 cites W3011093535 @default.
• W3162065141 cites W3011508296 @default.
• W3162065141 cites W3011537081 @default.
• W3162065141 cites W3012424007 @default.
• W3162065141 cites W3012694474 @default.
• W3162065141 cites W3012725239 @default.
• W3162065141 cites W3012818885 @default.
• W3162065141 cites W3013365852 @default.
• W3162065141 cites W3013458071 @default.
• W3162065141 cites W3013617732 @default.
• W3162065141 cites W3013694216 @default.
• W3162065141 cites W3014006087 @default.
• W3162065141 cites W3015228903 @default.
• W3162065141 cites W3017855104 @default.
• W3162065141 cites W3024970129 @default.
• W3162065141 cites W3027288772 @default.
• W3162065141 cites W3030036033 @default.
• W3162065141 cites W3031239482 @default.
• W3162065141 cites W3033126715 @default.
• W3162065141 cites W3033459419 @default.
• W3162065141 cites W3035895802 @default.
• W3162065141 cites W3036841663 @default.
• W3162065141 cites W3037482391 @default.
• W3162065141 cites W3041667892 @default.
• W3162065141 cites W3078858731 @default.
• W3162065141 cites W3080369903 @default.
• W3162065141 cites W3084045693 @default.
• W3162065141 cites W3097035060 @default.
• W3162065141 cites W3098799428 @default.
• W3162065141 cites W3106331819 @default.
• W3162065141 cites W3111990983 @default.
• W3162065141 cites W3112874642 @default.
• W3162065141 cites W3113132980 @default.
• W3162065141 cites W3115700180 @default.
• W3162065141 cites W3119200022 @default.
• W3162065141 cites W3120733696 @default.
• W3162065141 cites W3126740247 @default.
• W3162065141 cites W3134678523 @default.
• W3162065141 cites W4294215472 @default.
• W3162065141 cites W4320301345 @default.
• W3162065141 doi "https://doi.org/10.3390/medicina57050493" @default.
• W3162065141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8153122" @default.
• W3162065141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34068221" @default.

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