FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3162090803> ?p ?o ?g. }

• W3162090803 endingPage "589" @default.
• W3162090803 startingPage "589" @default.
• W3162090803 abstract "Biofilm formation is a critical health concern, involved in most human bacterial infections. Combatting this mechanism, which increases resistance to traditional antibiotics and host immune defences, requires novel therapeutic approaches. The remarkable biocide activity and the monodispersity of carbosilane metallodendrimers make them excellent platforms to evaluate the impact of different structural parameters on the biological activity. In this work, we explore the influence of iminopyridine ring substituents on the antibacterial activity against planktonic and biofilm Staphylococcus aureus. New families of first-generation Ru(II) and Cu(II) metallodendrimers were synthesised and analysed, in comparison to the non-substituted counterparts. The results showed that the presence of methyl or methoxy groups in meta position to the imine bond decreased the overall positive charge on the metal ion and, subsequently, the activity against planktonic bacteria. However, it seemed a relevant parameter to consider for the prevention of biofilm formation, if they contribute to increasing the overall lipophilicity. An optimum balance of the charge and lipophilicity of the metallodrug, accomplished through structural design, will provide effective biocide agents against bacteria biofilms." @default.
• W3162090803 created "2021-05-24" @default.
• W3162090803 creator A5001336225 @default.
• W3162090803 creator A5002197942 @default.
• W3162090803 creator A5022988974 @default.
• W3162090803 creator A5036113696 @default.
• W3162090803 creator A5046207123 @default.
• W3162090803 creator A5085285051 @default.
• W3162090803 date "2021-05-17" @default.
• W3162090803 modified "2023-10-14" @default.
• W3162090803 title "Insight on the Structure-to-Activity of Carbosilane Metallodendrimers in the Fight against Staphylococcus aureus Biofilms" @default.
• W3162090803 cites W116247891 @default.
• W3162090803 cites W1987497114 @default.
• W3162090803 cites W1994961495 @default.
• W3162090803 cites W2003959914 @default.
• W3162090803 cites W2060763657 @default.
• W3162090803 cites W2144440398 @default.
• W3162090803 cites W2236806673 @default.
• W3162090803 cites W2296449951 @default.
• W3162090803 cites W2313619242 @default.
• W3162090803 cites W2324648625 @default.
• W3162090803 cites W2481109770 @default.
• W3162090803 cites W2527646426 @default.
• W3162090803 cites W2605749465 @default.
• W3162090803 cites W2615828115 @default.
• W3162090803 cites W2759602013 @default.
• W3162090803 cites W2908459122 @default.
• W3162090803 cites W2946458716 @default.
• W3162090803 cites W2952043178 @default.
• W3162090803 cites W2953543696 @default.
• W3162090803 cites W2969239682 @default.
• W3162090803 cites W2973767429 @default.
• W3162090803 cites W3026343161 @default.
• W3162090803 cites W3086052176 @default.
• W3162090803 cites W3093071239 @default.
• W3162090803 cites W3133485834 @default.
• W3162090803 cites W4252043932 @default.
• W3162090803 doi "https://doi.org/10.3390/antibiotics10050589" @default.
• W3162090803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8156651" @default.
• W3162090803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34067558" @default.
• W3162090803 hasPublicationYear "2021" @default.
• W3162090803 type Work @default.
• W3162090803 sameAs 3162090803 @default.
• W3162090803 citedByCount "4" @default.
• W3162090803 countsByYear W31620908032022 @default.
• W3162090803 countsByYear W31620908032023 @default.
• W3162090803 crossrefType "journal-article" @default.
• W3162090803 hasAuthorship W3162090803A5001336225 @default.
• W3162090803 hasAuthorship W3162090803A5002197942 @default.
• W3162090803 hasAuthorship W3162090803A5022988974 @default.
• W3162090803 hasAuthorship W3162090803A5036113696 @default.
• W3162090803 hasAuthorship W3162090803A5046207123 @default.
• W3162090803 hasAuthorship W3162090803A5085285051 @default.
• W3162090803 hasBestOaLocation W31620908031 @default.
• W3162090803 hasConcept C118687296 @default.
• W3162090803 hasConcept C161790260 @default.
• W3162090803 hasConcept C178790620 @default.
• W3162090803 hasConcept C185592680 @default.
• W3162090803 hasConcept C197471484 @default.
• W3162090803 hasConcept C201399114 @default.
• W3162090803 hasConcept C21951064 @default.
• W3162090803 hasConcept C2776305277 @default.
• W3162090803 hasConcept C2779489039 @default.
• W3162090803 hasConcept C523546767 @default.
• W3162090803 hasConcept C54355233 @default.
• W3162090803 hasConcept C58123911 @default.
• W3162090803 hasConcept C71240020 @default.
• W3162090803 hasConcept C86803240 @default.
• W3162090803 hasConcept C89423630 @default.
• W3162090803 hasConceptScore W3162090803C118687296 @default.
• W3162090803 hasConceptScore W3162090803C161790260 @default.
• W3162090803 hasConceptScore W3162090803C178790620 @default.
• W3162090803 hasConceptScore W3162090803C185592680 @default.
• W3162090803 hasConceptScore W3162090803C197471484 @default.
• W3162090803 hasConceptScore W3162090803C201399114 @default.
• W3162090803 hasConceptScore W3162090803C21951064 @default.
• W3162090803 hasConceptScore W3162090803C2776305277 @default.
• W3162090803 hasConceptScore W3162090803C2779489039 @default.
• W3162090803 hasConceptScore W3162090803C523546767 @default.
• W3162090803 hasConceptScore W3162090803C54355233 @default.
• W3162090803 hasConceptScore W3162090803C58123911 @default.
• W3162090803 hasConceptScore W3162090803C71240020 @default.
• W3162090803 hasConceptScore W3162090803C86803240 @default.
• W3162090803 hasConceptScore W3162090803C89423630 @default.
• W3162090803 hasFunder F4320313831 @default.
• W3162090803 hasFunder F4320321837 @default.
• W3162090803 hasFunder F4320327216 @default.
• W3162090803 hasFunder F4320334923 @default.
• W3162090803 hasIssue "5" @default.
• W3162090803 hasLocation W31620908031 @default.
• W3162090803 hasLocation W31620908032 @default.
• W3162090803 hasLocation W31620908033 @default.
• W3162090803 hasOpenAccess W3162090803 @default.
• W3162090803 hasPrimaryLocation W31620908031 @default.
• W3162090803 hasRelatedWork W2058965595 @default.
• W3162090803 hasRelatedWork W2087735873 @default.
• W3162090803 hasRelatedWork W2136376928 @default.
• W3162090803 hasRelatedWork W2373514832 @default.

• next