Matches in SemOpenAlex for { <https://semopenalex.org/work/W3162127116> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W3162127116 abstract "Abstract Objectives Chronic kidney disease and atherosclerosis are considered to be inflammatory process in which T cells and cytokines participate. This study determines the effect of statin therapy as an anti-inflammatory agent on the level of CD4+CD28null T lymphocyte population, and subsequently on atherosclerosis in patients with chronic renal disease. Methods We recruited 90 chronic kidney disease patients. The patients were divided into three groups according to carotid intimal medial thickness (CIMT) as an indicator of atherosclerosis. Two groups (group A in whom CIMT above 0.95 mm and B in whom CIMT below 0.95 mm) were given statin (atorvastatin 20mg) while the third group (group C in whom CIMT below 0.95 mm) continue only on the conservative treatment for CKD patients. CD4+CD28null T cells was measured in the three groups at the beginning of the study and after 6 months of statin therapy. Results CD4+CD28null T cells was decreased in statin groups (group A and B) when compared to no-statin group (group C) at the end of the study. Multivariable regression analysis for the effect of statin therapy showed that statin can independently increase the percentage of decrease both CD4+CD28null cells at the end of our study (p-value <0.0001). Conclusion Our study demonstrates that statins reduce CD4+CD28null T cells in CKD patients especially with atherosclerosis suggesting that statins may help in altering the inflammatory process that lead to atherosclerosis." @default.
- W3162127116 created "2021-05-24" @default.
- W3162127116 creator A5026798359 @default.
- W3162127116 creator A5029079035 @default.
- W3162127116 creator A5051674124 @default.
- W3162127116 creator A5056575499 @default.
- W3162127116 creator A5061189715 @default.
- W3162127116 creator A5077493747 @default.
- W3162127116 date "2020-03-01" @default.
- W3162127116 modified "2023-09-27" @default.
- W3162127116 title "Effect of statins on atherosclerosis in chronic kidney disease patients guided by CD4+CD28nullT cells over duration of six months" @default.
- W3162127116 doi "https://doi.org/10.1093/qjmed/hcaa052.058" @default.
- W3162127116 hasPublicationYear "2020" @default.
- W3162127116 type Work @default.
- W3162127116 sameAs 3162127116 @default.
- W3162127116 citedByCount "0" @default.
- W3162127116 crossrefType "journal-article" @default.
- W3162127116 hasAuthorship W3162127116A5026798359 @default.
- W3162127116 hasAuthorship W3162127116A5029079035 @default.
- W3162127116 hasAuthorship W3162127116A5051674124 @default.
- W3162127116 hasAuthorship W3162127116A5056575499 @default.
- W3162127116 hasAuthorship W3162127116A5061189715 @default.
- W3162127116 hasAuthorship W3162127116A5077493747 @default.
- W3162127116 hasBestOaLocation W31621271161 @default.
- W3162127116 hasConcept C126322002 @default.
- W3162127116 hasConcept C164705383 @default.
- W3162127116 hasConcept C2776839432 @default.
- W3162127116 hasConcept C2776914184 @default.
- W3162127116 hasConcept C2777482532 @default.
- W3162127116 hasConcept C2778653478 @default.
- W3162127116 hasConcept C2908647359 @default.
- W3162127116 hasConcept C71924100 @default.
- W3162127116 hasConcept C90924648 @default.
- W3162127116 hasConcept C99454951 @default.
- W3162127116 hasConceptScore W3162127116C126322002 @default.
- W3162127116 hasConceptScore W3162127116C164705383 @default.
- W3162127116 hasConceptScore W3162127116C2776839432 @default.
- W3162127116 hasConceptScore W3162127116C2776914184 @default.
- W3162127116 hasConceptScore W3162127116C2777482532 @default.
- W3162127116 hasConceptScore W3162127116C2778653478 @default.
- W3162127116 hasConceptScore W3162127116C2908647359 @default.
- W3162127116 hasConceptScore W3162127116C71924100 @default.
- W3162127116 hasConceptScore W3162127116C90924648 @default.
- W3162127116 hasConceptScore W3162127116C99454951 @default.
- W3162127116 hasLocation W31621271161 @default.
- W3162127116 hasOpenAccess W3162127116 @default.
- W3162127116 hasPrimaryLocation W31621271161 @default.
- W3162127116 hasRelatedWork W11234326 @default.
- W3162127116 hasRelatedWork W11602846 @default.
- W3162127116 hasRelatedWork W14515203 @default.
- W3162127116 hasRelatedWork W15399405 @default.
- W3162127116 hasRelatedWork W17924961 @default.
- W3162127116 hasRelatedWork W17970106 @default.
- W3162127116 hasRelatedWork W2762914 @default.
- W3162127116 hasRelatedWork W16471212 @default.
- W3162127116 hasRelatedWork W17523298 @default.
- W3162127116 hasRelatedWork W8061235 @default.
- W3162127116 isParatext "false" @default.
- W3162127116 isRetracted "false" @default.
- W3162127116 magId "3162127116" @default.
- W3162127116 workType "article" @default.