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- W3162134210 abstract "Background: Echinochrome A (EchA) is a pigment from sea urchins. EchA is a polyhydroxylated 1,4-naphthoquinone that contains several hydroxyl groups appropriate for free-radical scavenging and preventing redox imbalance. EchA is the most studied molecule of this family and is an active principle approved to be used in humans, usually for cardiopathies and glaucoma. EchA is used as a pharmaceutical drug. Methods: A comprehensive literature and patent search review was undertaken using PubMed, as well as Google Scholar and Espacenet search engines to review these areas. Conclusions: In the bloodstream, EchA can mediate cellular responses, act as a radical scavenger, and activate the glutathione pathway. It decreases ROS imbalance, prevents and limits lipid peroxidation, and enhances mitochondrial functions. Most importantly, EchA contributes to the modulation of the immune system. EchA can regulate the generation of regulatory T cells, inhibit pro-inflammatory IL-1β and IL-6 cytokine production, while slightly reducing IL-8, TNF-α, INF-α, and NKT, thus correcting immune imbalance. These characteristics suggest that EchA is a candidate drug to alleviate the cytokine storm syndrome (CSS)." @default.
- W3162134210 created "2021-05-24" @default.
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- W3162134210 creator A5015240170 @default.
- W3162134210 creator A5088589977 @default.
- W3162134210 date "2021-05-11" @default.
- W3162134210 modified "2023-10-13" @default.
- W3162134210 title "Sea Urchin Pigments: Echinochrome A and Its Potential Implication in the Cytokine Storm Syndrome" @default.
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- W3162134210 doi "https://doi.org/10.3390/md19050267" @default.
- W3162134210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8151293" @default.
- W3162134210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34064550" @default.
- W3162134210 hasPublicationYear "2021" @default.
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