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- W3162137648 abstract "New national recommendations in England state that fetal weight should be estimated at the time of the anomaly scan and, if below the tenth centile of an unspecified standard, should be considered high risk requiring specialist referral. We wanted to investigate the degree of variation that might result when using different standards for fetal weight at early gestations. The tenth percentile values according to Hadlock1, INTERGROWTH-21st (IG21)2 and Gestation Related Optimal Growth (GROW)3 were compared at 22 weeks (the earliest gestational age in IG21 tables). As the GROW standard varies with maternal physiological characteristics, GROW p10 values were also provided for large mothers at upper end (75th centile) and small mothers at lower end (25th centile) of the interquartile (IQ) range of GROW charts provided in the UK population. Hadlock and IG21 were compared with GROW at these points and differences calculated as percent variation in SGA rate, based on the standard deviation of the respective distributions. The 22.0 week values for the 10th centile were 398g (Hadlock), 481g (IG21) and 389g (GROW), with an IQ range of 363-411g. The discrepancy between Hadlock and GROW of cases considered SGA ranged from -36.8% (underestimated by Hadlock) to +79.0% (overestimated by Hadlock). IG21 values substantially overestimated SGA rates across the whole range of GROW measurements (+95.5% - +99.9%). Early pregnancy screening for estimated fetal weight <10th centile as a risk factor is highly dependent on the reference values used, and will result in a large numbers of false positive and false negative assessments unless a standard is used which is appropriate for the population and customised for each pregnancy. REFERENCES 1. Hadlock FP et al. Radiology. 1991; 181: 129–133. 2. Stirnemann J et al. UOG 2017; 1; 49: 478–86. 3. GROW v1.2.6.1, 2019. www.gestation.net" @default.
- W3162137648 created "2021-05-24" @default.
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- W3162137648 date "2020-10-01" @default.
- W3162137648 modified "2023-09-26" @default.
- W3162137648 title "VP41.03: Customised‐ versus population‐based fetal weight standards to define small for gestational age at 22 weeks of gestation" @default.
- W3162137648 doi "https://doi.org/10.1002/uog.22967" @default.
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