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• W3162139160 endingPage "101691" @default.
• W3162139160 startingPage "101691" @default.
• W3162139160 abstract "Psoriatic arthritis (PsA) is caused by a combination of environmental and multiple genetic factors, with clear evidence for a strong genetic basis. The remarkable accumulation of knowledge gained from genetic, pharmacogenetic, and therapeutic response of biologic agents in PsA has fundamentally changed and advanced our understanding of disease pathogenesis and has identified key signalling pathways. However, only one-quarter of the genetic contribution of PsA has been accounted for; and dissecting the genetic contributors of the cutaneous disease from those that would identify joint disease has been challenging. More importantly, the clinical utility of multiple proposed loci is unclear. In this review, we summarize the potential clinical relevance from established genetic associations and provide insight on the proposed molecular pathways that arise from these associations." @default.
• W3162139160 created "2021-05-24" @default.
• W3162139160 creator A5046987976 @default.
• W3162139160 creator A5065964920 @default.
• W3162139160 date "2021-06-01" @default.
• W3162139160 modified "2023-10-14" @default.
• W3162139160 title "Clinical and molecular significance of genetic loci associated with psoriatic arthritis" @default.
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• W3162139160 doi "https://doi.org/10.1016/j.berh.2021.101691" @default.

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