Matches in SemOpenAlex for { <https://semopenalex.org/work/W3162152982> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W3162152982 abstract "Abstract Background Early diagnosis and prognosis rely on the successful identification of biomarkers and understanding the mechanisms. The morbidity and mortality rate of gastrointestinal tumors rank sixth and fourth amongst malignant tumors, with 5 years survival rate of only 15%-20%, therefore it is crucial to develop novel molecular tools and methods for prognosis. Methods Through pan-cancer analysis amongst three types of gastrointestinal tumors, we constructed competitive endogenous RNA (ceRNA) networks, differentially expressed set of genes were distinguished, validated, and analyzed, their relevance to survival elucidated with immune infiltration profiles. Shared genes in esophageal, gastric and colon cancers were found significantly enriched in the processes of cell cycle, cell differentiation, DNA replication, synaptic transmission, the cyclic guanosine monophosphate protein-dependent protein kinase (cGMP-PKG) signaling pathway, and the glutamate receptor and other functions. Results Principal component analysis of the ceRNA network suggested the expression patterns of identified genes. Using Cox regression analysis of mRNAs, miRNAs and lncRNAs in the ceRNA network, genes including hsa-mir-196b, hsa-mir-584, PPP1R12B, SYNM, PDE2A, ALDH6A1 and MIR22HG were found significantly survival-related. Conclusions Receiver operating characteristic (ROC) curve analysis and decision curve analysis (DCA) showed that the identified genes were not related to the survival in thyroid nor breast cancers, but effective for the prognosis of gastrointestinal tumors. These results could provide new theoretical and experimental clues, unravel the mechanisms, assisting molecular diagnosis and prognosis of gastrointestinal tumors." @default.
- W3162152982 created "2021-05-24" @default.
- W3162152982 creator A5011172190 @default.
- W3162152982 creator A5038984650 @default.
- W3162152982 creator A5050861817 @default.
- W3162152982 creator A5065173002 @default.
- W3162152982 creator A5068994643 @default.
- W3162152982 creator A5084963625 @default.
- W3162152982 date "2021-05-10" @default.
- W3162152982 modified "2023-09-25" @default.
- W3162152982 title "Construction and integrated analysis of ceRNA networks identified survival-related genes in gastrointestinal tumors" @default.
- W3162152982 doi "https://doi.org/10.21203/rs.3.rs-432424/v1" @default.
- W3162152982 hasPublicationYear "2021" @default.
- W3162152982 type Work @default.
- W3162152982 sameAs 3162152982 @default.
- W3162152982 citedByCount "0" @default.
- W3162152982 crossrefType "posted-content" @default.
- W3162152982 hasAuthorship W3162152982A5011172190 @default.
- W3162152982 hasAuthorship W3162152982A5038984650 @default.
- W3162152982 hasAuthorship W3162152982A5050861817 @default.
- W3162152982 hasAuthorship W3162152982A5065173002 @default.
- W3162152982 hasAuthorship W3162152982A5068994643 @default.
- W3162152982 hasAuthorship W3162152982A5084963625 @default.
- W3162152982 hasBestOaLocation W31621529821 @default.
- W3162152982 hasConcept C104317684 @default.
- W3162152982 hasConcept C10515644 @default.
- W3162152982 hasConcept C126322002 @default.
- W3162152982 hasConcept C143998085 @default.
- W3162152982 hasConcept C145059251 @default.
- W3162152982 hasConcept C502942594 @default.
- W3162152982 hasConcept C54355233 @default.
- W3162152982 hasConcept C60365752 @default.
- W3162152982 hasConcept C60644358 @default.
- W3162152982 hasConcept C62203573 @default.
- W3162152982 hasConcept C67705224 @default.
- W3162152982 hasConcept C70721500 @default.
- W3162152982 hasConcept C71924100 @default.
- W3162152982 hasConcept C86803240 @default.
- W3162152982 hasConceptScore W3162152982C104317684 @default.
- W3162152982 hasConceptScore W3162152982C10515644 @default.
- W3162152982 hasConceptScore W3162152982C126322002 @default.
- W3162152982 hasConceptScore W3162152982C143998085 @default.
- W3162152982 hasConceptScore W3162152982C145059251 @default.
- W3162152982 hasConceptScore W3162152982C502942594 @default.
- W3162152982 hasConceptScore W3162152982C54355233 @default.
- W3162152982 hasConceptScore W3162152982C60365752 @default.
- W3162152982 hasConceptScore W3162152982C60644358 @default.
- W3162152982 hasConceptScore W3162152982C62203573 @default.
- W3162152982 hasConceptScore W3162152982C67705224 @default.
- W3162152982 hasConceptScore W3162152982C70721500 @default.
- W3162152982 hasConceptScore W3162152982C71924100 @default.
- W3162152982 hasConceptScore W3162152982C86803240 @default.
- W3162152982 hasLocation W31621529821 @default.
- W3162152982 hasOpenAccess W3162152982 @default.
- W3162152982 hasPrimaryLocation W31621529821 @default.
- W3162152982 hasRelatedWork W2135687976 @default.
- W3162152982 hasRelatedWork W2473455681 @default.
- W3162152982 hasRelatedWork W2557582719 @default.
- W3162152982 hasRelatedWork W2805745868 @default.
- W3162152982 hasRelatedWork W3000331993 @default.
- W3162152982 hasRelatedWork W3108613021 @default.
- W3162152982 hasRelatedWork W3191462603 @default.
- W3162152982 hasRelatedWork W3200763748 @default.
- W3162152982 hasRelatedWork W4313236721 @default.
- W3162152982 hasRelatedWork W2187157699 @default.
- W3162152982 isParatext "false" @default.
- W3162152982 isRetracted "false" @default.
- W3162152982 magId "3162152982" @default.
- W3162152982 workType "article" @default.