FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3162180356> ?p ?o ?g. }

• W3162180356 endingPage "e210347" @default.
• W3162180356 startingPage "e210347" @default.
• W3162180356 abstract "Rotavirus vaccines have been introduced worldwide, and the clinical association of different rotavirus vaccines with reduction in rotavirus gastroenteritis (RVGE) after introduction are noteworthy.To evaluate the comparative benefit, risk, and immunogenicity of different rotavirus vaccines by synthesizing randomized clinical trials (RCTs) and observational studies.Relevant studies published in 4 databases: Embase, PubMed, the Cochrane Library, and Web of Science were searched until July 1, 2020, using search terms including rotavirus and vaccin*.Randomized clinical trials and cohort and case-control studies involving more than 100 children younger than 5 years that reported the effectiveness, safety, or immunogenicity of rotavirus vaccines were included.A random-effects model was used to calculate relative risks (RRs), odds ratios (ORs), risk differences, and 95% CIs. Adjusted indirect treatment comparison was performed to assess the differences in the protection of Rotarix and RotaTeq.The primary outcomes were RVGE, severe RVGE, and RVGE hospitalization. Safety-associated outcomes involved serious adverse events, intussusception, and mortality.A meta-analysis of 20 RCTs and 38 case-control studies revealed that Rotarix (RV1) significantly reduced RVGE (RR, 0.316 [95% CI, 0.224-0.345]) and RVGE hospitalization risk (OR, 0.347 [95% CI, 0.279-0.432]) among children fully vaccinated; RotaTeq (RV5) had similar outcomes (RVGE: RR, 0.350 [95% CI, 0.275-0.445]; RVGE hospitalization risk: OR, 0.272 [95% CI, 0.197-0.376]). Rotavirus vaccines also demonstrated higher protection against severe RVGE. Additionally, no significant differences in the protection of RV1 and RV5 against rotavirus disease were noted in adjusted indirect comparisons. Moderate associations were found between reduced RVGE risk and Rotavac (RR, 0.664 [95% CI, 0.548-0.804]), Rotasiil (RR, 0.705 [95% CI, 0.605-0.821]), and Lanzhou lamb rotavirus vaccine (RR, 0.407 [95% CI, 0.332-0.499]). All rotavirus vaccines demonstrated no risk of serious adverse events. A positive correlation was also found between immunogenicity and vaccine protection (eg, association of RVGE with RV1: coefficient, -1.599; adjusted R2, 99.7%).The high protection and low risk of serious adverse events for rotavirus vaccines in children who were fully vaccinated emphasized the importance of worldwide introduction of rotavirus vaccination. Similar protection provided by Rotarix and RotaTeq relieves the pressure of vaccines selection for health care authorities." @default.
• W3162180356 created "2021-05-24" @default.
• W3162180356 creator A5003163952 @default.
• W3162180356 creator A5013631283 @default.
• W3162180356 creator A5018785155 @default.
• W3162180356 creator A5025341469 @default.
• W3162180356 creator A5039444574 @default.
• W3162180356 creator A5066037312 @default.
• W3162180356 creator A5075035689 @default.
• W3162180356 date "2021-07-06" @default.
• W3162180356 modified "2023-10-18" @default.
• W3162180356 title "Association of Rotavirus Vaccines With Reduction in Rotavirus Gastroenteritis in Children Younger Than 5 Years" @default.
• W3162180356 cites W1773667642 @default.
• W3162180356 cites W1924998122 @default.
• W3162180356 cites W1952022758 @default.
• W3162180356 cites W1964472667 @default.
• W3162180356 cites W1965526538 @default.
• W3162180356 cites W1970024449 @default.
• W3162180356 cites W1972820510 @default.
• W3162180356 cites W1975088726 @default.
• W3162180356 cites W1976579888 @default.
• W3162180356 cites W1982309623 @default.
• W3162180356 cites W1985183611 @default.
• W3162180356 cites W1987459358 @default.
• W3162180356 cites W1987891326 @default.
• W3162180356 cites W1988557503 @default.
• W3162180356 cites W1989064407 @default.
• W3162180356 cites W1990910503 @default.
• W3162180356 cites W1992990024 @default.
• W3162180356 cites W1995283258 @default.
• W3162180356 cites W1998506676 @default.
• W3162180356 cites W1999762730 @default.
• W3162180356 cites W2001533895 @default.
• W3162180356 cites W2001873492 @default.
• W3162180356 cites W2005301495 @default.
• W3162180356 cites W2010538695 @default.
• W3162180356 cites W2017226367 @default.
• W3162180356 cites W2017882908 @default.
• W3162180356 cites W2018350176 @default.
• W3162180356 cites W2021386032 @default.
• W3162180356 cites W2021413412 @default.
• W3162180356 cites W2022086407 @default.
• W3162180356 cites W2024651995 @default.
• W3162180356 cites W2026800191 @default.
• W3162180356 cites W2029452230 @default.
• W3162180356 cites W2029655227 @default.
• W3162180356 cites W2033338544 @default.
• W3162180356 cites W2037025873 @default.
• W3162180356 cites W2039403264 @default.
• W3162180356 cites W2039862142 @default.
• W3162180356 cites W2039955618 @default.
• W3162180356 cites W2040079691 @default.
• W3162180356 cites W2040317656 @default.
• W3162180356 cites W2040393189 @default.
• W3162180356 cites W2044265671 @default.
• W3162180356 cites W2047097961 @default.
• W3162180356 cites W2048825668 @default.
• W3162180356 cites W2050844412 @default.
• W3162180356 cites W2051025368 @default.
• W3162180356 cites W2054184633 @default.
• W3162180356 cites W2054554539 @default.
• W3162180356 cites W2055735989 @default.
• W3162180356 cites W2059080184 @default.
• W3162180356 cites W2059519302 @default.
• W3162180356 cites W2065942818 @default.
• W3162180356 cites W2066187043 @default.
• W3162180356 cites W2066543671 @default.
• W3162180356 cites W2072490459 @default.
• W3162180356 cites W2074761425 @default.
• W3162180356 cites W2083934734 @default.
• W3162180356 cites W2089107410 @default.
• W3162180356 cites W2092090915 @default.
• W3162180356 cites W2095204653 @default.
• W3162180356 cites W2097602187 @default.
• W3162180356 cites W2100178369 @default.
• W3162180356 cites W2101100687 @default.
• W3162180356 cites W2101380815 @default.
• W3162180356 cites W2103861589 @default.
• W3162180356 cites W2105743020 @default.
• W3162180356 cites W2110001653 @default.
• W3162180356 cites W2113014022 @default.
• W3162180356 cites W2116607053 @default.
• W3162180356 cites W2119010259 @default.
• W3162180356 cites W2131073529 @default.
• W3162180356 cites W2135985984 @default.
• W3162180356 cites W2143233237 @default.
• W3162180356 cites W2143340635 @default.
• W3162180356 cites W2146147908 @default.
• W3162180356 cites W2147463960 @default.
• W3162180356 cites W2148326834 @default.
• W3162180356 cites W2150294366 @default.
• W3162180356 cites W2150741463 @default.
• W3162180356 cites W2154855506 @default.
• W3162180356 cites W2157252102 @default.
• W3162180356 cites W2158178343 @default.
• W3162180356 cites W2160624250 @default.
• W3162180356 cites W2163306701 @default.
• W3162180356 cites W2168275109 @default.

• next