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- W3162184531 startingPage "4652" @default.
- W3162184531 abstract "Abstract The human hippocampus is involved in forming new memories: damage impairs memory. The dual stream model suggests that object “what” representations from ventral stream temporal cortex project to the hippocampus via the perirhinal and then lateral entorhinal cortex, and spatial “where” representations from the dorsal parietal stream via the parahippocampal gyrus and then medial entorhinal cortex. The hippocampus can then associate these inputs to form episodic memories of what happened where. Diffusion tractography was used to reveal the direct connections of hippocampal system areas in humans. This provides evidence that the human hippocampus has extensive direct cortical connections, with connections that bypass the entorhinal cortex to connect with the perirhinal and parahippocampal cortex, with the temporal pole, with the posterior and retrosplenial cingulate cortex, and even with early sensory cortical areas. The connections are less hierarchical and segregated than in the dual stream model. This provides a foundation for a conceptualization for how the hippocampal memory system connects with the cerebral cortex and operates in humans. One implication is that prehippocampal cortical areas such as the parahippocampal TF and TH subregions and perirhinal cortices may implement specialized computations that can benefit from inputs from the dorsal and ventral streams." @default.
- W3162184531 created "2021-05-24" @default.
- W3162184531 creator A5029186968 @default.
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- W3162184531 creator A5089472956 @default.
- W3162184531 date "2021-05-19" @default.
- W3162184531 modified "2023-10-14" @default.
- W3162184531 title "Extensive Cortical Connectivity of the Human Hippocampal Memory System: Beyond the “What” and “Where” Dual Stream Model" @default.
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