FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3162189894> ?p ?o ?g. }

• W3162189894 endingPage "934" @default.
• W3162189894 startingPage "924" @default.
• W3162189894 abstract "Forty percent of critically ill trauma patients will develop an infectious complication. Pneumonia is the most common cause of death of trauma patients surviving their initial insult. We previously demonstrated that polytrauma (PT), defined as two or more severe injuries in at least two areas of the body, induces emergency hematopoiesis characterized by accelerated myelopoiesis in the bone marrow and increased myeloid cell frequency in the peripheral tissues. We hypothesized that PT alone induces priming of neutrophils, resulting in hyperactivation upon secondary exposure to bacteria and causing acute lung injury and increased susceptibility to secondary exposure to Pseudomonas aeruginosa pneumonia.C57BL/6 mice were subjected to PT consisting of a lower extremity pseudofracture, liver crush injury, and 15% blood-volume hemorrhage. Pneumonia was induced by intratracheal injection of 5 × 106 CFU live P. aeruginosa or 1 × 107 of heat-killed P. aeruginosa (HKPA). For reactive oxygen species (ROS), studies polymorphonuclear neutrophils (PMNs) were isolated by immunomagnetic bead negative selection and stimulated ex-vivo with HKPA. Reactive oxygen species production was measured by immunofluorescence. For histology, lung sections were stained by hematoxylin-eosin and analyzed by a blinded grader.Polytrauma induced persistent changes in immune function at baseline and to secondary infection. Pneumonia after injury resulted in increased mortality (60% vs. 5% p < 0.01). Blood neutrophils from PT mice had higher resting (unstimulated) ROS production than in naive animals (p < 0.02) demonstrating priming of the neutrophils following PT. After intratracheal HKPA injection, bronchoalveolar lavage PMNs from injured mice had higher ROS production compared with naive mice (p < 0.01), demonstrating an overexuberant immunopathologic response of neutrophils following PT.Polytrauma primes neutrophils and causes immunopathologic PMN ROS production, increased lung injury and susceptibility to secondary bacterial pneumonia. These results suggest that trauma-induced immune dysfunction can cause immunopathologic response to secondary infection and suggests neutrophil-mediated pulmonary damage as a therapeutic target for posttrauma pneumonia." @default.
• W3162189894 created "2021-05-24" @default.
• W3162189894 creator A5002699027 @default.
• W3162189894 creator A5024134070 @default.
• W3162189894 creator A5024236989 @default.
• W3162189894 creator A5027173986 @default.
• W3162189894 creator A5028603451 @default.
• W3162189894 creator A5030350840 @default.
• W3162189894 creator A5031714796 @default.
• W3162189894 creator A5043902991 @default.
• W3162189894 creator A5057201132 @default.
• W3162189894 creator A5064388746 @default.
• W3162189894 creator A5066336938 @default.
• W3162189894 date "2021-06-01" @default.
• W3162189894 modified "2023-10-06" @default.
• W3162189894 title "Extrathoracic multiple trauma dysregulates neutrophil function and exacerbates pneumonia-induced lung injury" @default.
• W3162189894 cites W1966375310 @default.
• W3162189894 cites W1975867360 @default.
• W3162189894 cites W1982034147 @default.
• W3162189894 cites W1990819855 @default.
• W3162189894 cites W2004617421 @default.
• W3162189894 cites W2014825462 @default.
• W3162189894 cites W2021202286 @default.
• W3162189894 cites W2023749604 @default.
• W3162189894 cites W2025223358 @default.
• W3162189894 cites W2025565469 @default.
• W3162189894 cites W2025775488 @default.
• W3162189894 cites W2036028217 @default.
• W3162189894 cites W2049927856 @default.
• W3162189894 cites W2061341693 @default.
• W3162189894 cites W2074852058 @default.
• W3162189894 cites W2080501285 @default.
• W3162189894 cites W2086178215 @default.
• W3162189894 cites W2091150961 @default.
• W3162189894 cites W2097364950 @default.
• W3162189894 cites W2116905801 @default.
• W3162189894 cites W2155800098 @default.
• W3162189894 cites W2322879156 @default.
• W3162189894 cites W2740653397 @default.
• W3162189894 cites W2763187490 @default.
• W3162189894 cites W2906152721 @default.
• W3162189894 cites W2939184326 @default.
• W3162189894 cites W2990232688 @default.
• W3162189894 cites W4211253912 @default.
• W3162189894 doi "https://doi.org/10.1097/ta.0000000000003147" @default.
• W3162189894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34016916" @default.
• W3162189894 hasPublicationYear "2021" @default.
• W3162189894 type Work @default.
• W3162189894 sameAs 3162189894 @default.
• W3162189894 citedByCount "6" @default.
• W3162189894 countsByYear W31621898942021 @default.
• W3162189894 countsByYear W31621898942023 @default.
• W3162189894 crossrefType "journal-article" @default.
• W3162189894 hasAuthorship W3162189894A5002699027 @default.
• W3162189894 hasAuthorship W3162189894A5024134070 @default.
• W3162189894 hasAuthorship W3162189894A5024236989 @default.
• W3162189894 hasAuthorship W3162189894A5027173986 @default.
• W3162189894 hasAuthorship W3162189894A5028603451 @default.
• W3162189894 hasAuthorship W3162189894A5030350840 @default.
• W3162189894 hasAuthorship W3162189894A5031714796 @default.
• W3162189894 hasAuthorship W3162189894A5043902991 @default.
• W3162189894 hasAuthorship W3162189894A5057201132 @default.
• W3162189894 hasAuthorship W3162189894A5064388746 @default.
• W3162189894 hasAuthorship W3162189894A5066336938 @default.
• W3162189894 hasBestOaLocation W31621898942 @default.
• W3162189894 hasConcept C126322002 @default.
• W3162189894 hasConcept C141071460 @default.
• W3162189894 hasConcept C142724271 @default.
• W3162189894 hasConcept C203014093 @default.
• W3162189894 hasConcept C2776692886 @default.
• W3162189894 hasConcept C2777714996 @default.
• W3162189894 hasConcept C2777914695 @default.
• W3162189894 hasConcept C2777961210 @default.
• W3162189894 hasConcept C2780007613 @default.
• W3162189894 hasConcept C71924100 @default.
• W3162189894 hasConceptScore W3162189894C126322002 @default.
• W3162189894 hasConceptScore W3162189894C141071460 @default.
• W3162189894 hasConceptScore W3162189894C142724271 @default.
• W3162189894 hasConceptScore W3162189894C203014093 @default.
• W3162189894 hasConceptScore W3162189894C2776692886 @default.
• W3162189894 hasConceptScore W3162189894C2777714996 @default.
• W3162189894 hasConceptScore W3162189894C2777914695 @default.
• W3162189894 hasConceptScore W3162189894C2777961210 @default.
• W3162189894 hasConceptScore W3162189894C2780007613 @default.
• W3162189894 hasConceptScore W3162189894C71924100 @default.
• W3162189894 hasIssue "6" @default.
• W3162189894 hasLocation W31621898941 @default.
• W3162189894 hasLocation W31621898942 @default.
• W3162189894 hasLocation W31621898943 @default.
• W3162189894 hasOpenAccess W3162189894 @default.
• W3162189894 hasPrimaryLocation W31621898941 @default.
• W3162189894 hasRelatedWork W1980145516 @default.
• W3162189894 hasRelatedWork W1991966802 @default.
• W3162189894 hasRelatedWork W2089544727 @default.
• W3162189894 hasRelatedWork W2118429353 @default.
• W3162189894 hasRelatedWork W2130346480 @default.
• W3162189894 hasRelatedWork W2265965265 @default.
• W3162189894 hasRelatedWork W2324306698 @default.

• next