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- W3162192144 abstract "Human skin and hair pigmentation play important roles in social behavior but also in photoprotection from the harmful effects of ultraviolet light. The main pigments in mammalian skin, the melanins, are synthesized within specialized organelles called melanosomes in melanocytes, which sit at the basal layer of the epidermis and the hair bulb. The melanins are then transferred from melanocytes to keratinocytes, where they accumulate perinuclearly in membrane-bound organelles as a cap above the nucleus. The mechanism of transfer, the nature of the pigmented organelles within keratinocytes, and the mechanism governing their intracellular positioning are all debated and poorly understood, but likely play an important role in the photoprotective properties of melanin in the skin. Here, we detail our current understanding of these processes and present a guideline for future experimentation in this area." @default.
- W3162192144 created "2021-05-24" @default.
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- W3162192144 date "2021-05-21" @default.
- W3162192144 modified "2023-10-09" @default.
- W3162192144 title "Melanin Transfer and Fate within Keratinocytes in Human Skin Pigmentation" @default.
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- W3162192144 doi "https://doi.org/10.1093/icb/icab094" @default.
- W3162192144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8516110" @default.
- W3162192144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34021340" @default.
- W3162192144 hasPublicationYear "2021" @default.
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