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• W3162199069 endingPage "104933" @default.
• W3162199069 startingPage "104933" @default.
• W3162199069 abstract "The recent outbreak of viral infection and its transmission has highlighted the importance of its slowdown for the safeguard of public health, globally. The identification of novel drugs and efficient therapies against these infectious viruses is need of the hour. The eruption of COVID-19 is caused by a novel acute respiratory syndrome virus SARS-CoV-2 which has taken the whole world by storm as it has transformed into a global pandemic. This lethal syndrome is a global health threat to general public which has already affected millions of people. Despite the development of some potential vaccines and repurposed drugs by some Pharma companies, this health emergency needs more attention due to the less efficacy of these vaccines coupled with the emergence of novel and resistant strains of SARS-CoV-2. Due to enormous structural diversity and biological applications, natural products are considered as a wonderful source of drugs for such diseases. Natural product based drugs constitute a substantial proportion of the pharmaceutical market particularly in the therapeutic areas of infectious diseases and oncology. The naturally occurring bioactive antiviral phytochemicals including alkaloids, flavonoids and peptides have been subjected to virtual screening against COVID-19. Since there is no specific medicine available for the treatment of Covid-19, designing new drugs using in silico methods plays an all important role to find that magic bullet which can target this lethal virus. The in silico method is not only quick but economical also when compared to the other conventional methods which are hit and trial methods. Based on this in silico approach, various natural products have been recently identified which might have a potential to inhibit COVID-19 outbreak. These natural products have been shown by these docking studies to interact with the spike protein of the novel coronavirus. This spike protein has been shown to bind to a transmembrane protein called Angiotensin converting enzyme 2 (ACE2), this protein acts as a receptor for the viral spike protein. This comprehensive review article anticipates providing a summary of the authentic and peer reviewed published literature about the potential of natural metabolites that can be developed into possible lead compounds against this new threat of Covid-19. Main focus of the article will be to highlight natural sources of potential anti-coronavirus molecules, mechanism of action, docking studies and the target proteins as well as their toxicity profiles. This review article intends to provide a starting point for the research endeavors that are needed for the design and development of drugs based on pure natural products, their synthetic or semi-synthetic derivatives and standardized plant extracts. This review article will be highly helpful for scientists who are working or intend to work on antiviral drugs from natural sources." @default.
• W3162199069 created "2021-05-24" @default.
• W3162199069 creator A5008549400 @default.
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• W3162199069 date "2021-08-01" @default.
• W3162199069 modified "2023-09-24" @default.
• W3162199069 title "Molecular scaffolds from mother nature as possible lead compounds in drug design and discovery against coronaviruses: A landscape analysis of published literature and molecular docking studies" @default.
• W3162199069 cites W1485020764 @default.
• W3162199069 cites W1526793828 @default.
• W3162199069 cites W1542641435 @default.
• W3162199069 cites W1551068445 @default.
• W3162199069 cites W1567784860 @default.
• W3162199069 cites W1577771017 @default.
• W3162199069 cites W1862727846 @default.
• W3162199069 cites W190828953 @default.
• W3162199069 cites W1913684051 @default.
• W3162199069 cites W1937553338 @default.
• W3162199069 cites W1965435260 @default.
• W3162199069 cites W1966238900 @default.
• W3162199069 cites W1967032468 @default.
• W3162199069 cites W1968592882 @default.
• W3162199069 cites W1969860618 @default.
• W3162199069 cites W1971290134 @default.
• W3162199069 cites W1974479059 @default.
• W3162199069 cites W1977610810 @default.
• W3162199069 cites W1978218725 @default.
• W3162199069 cites W1978897742 @default.
• W3162199069 cites W1979615660 @default.
• W3162199069 cites W1982533785 @default.
• W3162199069 cites W1983342808 @default.
• W3162199069 cites W1985652369 @default.
• W3162199069 cites W1988329787 @default.
• W3162199069 cites W1998663114 @default.
• W3162199069 cites W1999410197 @default.
• W3162199069 cites W1999888268 @default.
• W3162199069 cites W2008236308 @default.
• W3162199069 cites W2009195610 @default.
• W3162199069 cites W2013194501 @default.
• W3162199069 cites W2014737095 @default.
• W3162199069 cites W2017191121 @default.
• W3162199069 cites W2020896146 @default.
• W3162199069 cites W2029627660 @default.
• W3162199069 cites W2032830483 @default.
• W3162199069 cites W2033588551 @default.
• W3162199069 cites W2035409502 @default.
• W3162199069 cites W2035592278 @default.
• W3162199069 cites W2037391176 @default.
• W3162199069 cites W2038918691 @default.
• W3162199069 cites W2039689649 @default.
• W3162199069 cites W2044721777 @default.
• W3162199069 cites W2045578677 @default.
• W3162199069 cites W2046340642 @default.
• W3162199069 cites W2048030072 @default.
• W3162199069 cites W2048303730 @default.
• W3162199069 cites W2060542507 @default.
• W3162199069 cites W2064350446 @default.
• W3162199069 cites W2067279877 @default.
• W3162199069 cites W2068303130 @default.
• W3162199069 cites W2071569701 @default.
• W3162199069 cites W2072542018 @default.
• W3162199069 cites W2077524199 @default.
• W3162199069 cites W2078510009 @default.
• W3162199069 cites W2082873114 @default.
• W3162199069 cites W2083392747 @default.
• W3162199069 cites W2088969557 @default.
• W3162199069 cites W2091638124 @default.
• W3162199069 cites W2093884395 @default.
• W3162199069 cites W2098452672 @default.
• W3162199069 cites W2102380386 @default.
• W3162199069 cites W2103854602 @default.
• W3162199069 cites W2105626573 @default.
• W3162199069 cites W2106250183 @default.
• W3162199069 cites W2109224244 @default.
• W3162199069 cites W2115256867 @default.
• W3162199069 cites W2115672491 @default.
• W3162199069 cites W2119111857 @default.
• W3162199069 cites W2119494556 @default.
• W3162199069 cites W2123114567 @default.
• W3162199069 cites W2127294603 @default.
• W3162199069 cites W2136916161 @default.
• W3162199069 cites W2139153938 @default.
• W3162199069 cites W2140603934 @default.
• W3162199069 cites W2140734584 @default.
• W3162199069 cites W2143859507 @default.
• W3162199069 cites W2146242600 @default.
• W3162199069 cites W2146476111 @default.
• W3162199069 cites W2160775938 @default.
• W3162199069 cites W2161687688 @default.
• W3162199069 cites W2169558621 @default.
• W3162199069 cites W2170017134 @default.
• W3162199069 cites W2171353131 @default.
• W3162199069 cites W2212428843 @default.
• W3162199069 cites W2215640744 @default.
• W3162199069 cites W2255243349 @default.

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