Matches in SemOpenAlex for { <https://semopenalex.org/work/W3162304792> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3162304792 abstract "Abstract Numerous scientific experiments have been conducted in space. However, the precise mechanisms mediating successful human body adaption to the hostile space environment are still not delineated. The cost and logistic challenges of sending biological payloads to International Space Station are forcing scientists to find alternative research platforms. In this study, we investigated whether brief exposure to microgravity during the suborbital flight aboard Blue Origin’s New Shepard rocket modulated the behavior of the gravity-sensitive murine T cells. We assessed the effect of suborbital environment on different T cell subsets, activation markers, functionality, and cytokine secretion capabilities. Thus, to optimize the potential response of T cells, we cultured them in interleukin IL-2 alone or combined with IL-12. We found that exposure to microgravity decreased the expression of T cells with CD4+ cells being more sensitive to suborbital flight as compared to CD8+ cells. Our data indicate that the functional capabilities of flown T cells were reduced. Also, our findings suggest that supplementing cells with IL-2 and IL-12 cytokines may restore microgravity-mediated cellular alterations. Finally, our study provides insights on the microgravity effect on the murine T cells by utilizing a novel suborbital research platform." @default.
- W3162304792 created "2021-05-24" @default.
- W3162304792 creator A5004502216 @default.
- W3162304792 creator A5016549258 @default.
- W3162304792 creator A5017678670 @default.
- W3162304792 creator A5075165777 @default.
- W3162304792 creator A5083226841 @default.
- W3162304792 creator A5089274703 @default.
- W3162304792 date "2021-05-13" @default.
- W3162304792 modified "2023-10-12" @default.
- W3162304792 title "Microgravity effect on murine T cells exposed to suborbital flight aboard Blue Origin’s New Shepard vehicle" @default.
- W3162304792 cites W1491046533 @default.
- W3162304792 cites W1566992315 @default.
- W3162304792 cites W1588589005 @default.
- W3162304792 cites W1885103284 @default.
- W3162304792 cites W1963416087 @default.
- W3162304792 cites W1969982905 @default.
- W3162304792 cites W1973209475 @default.
- W3162304792 cites W1997866086 @default.
- W3162304792 cites W2053336880 @default.
- W3162304792 cites W2053665503 @default.
- W3162304792 cites W2071813691 @default.
- W3162304792 cites W2093755210 @default.
- W3162304792 cites W2107766352 @default.
- W3162304792 cites W2126229909 @default.
- W3162304792 cites W2142652155 @default.
- W3162304792 cites W2157278114 @default.
- W3162304792 cites W2166332777 @default.
- W3162304792 cites W2167559194 @default.
- W3162304792 cites W2185723293 @default.
- W3162304792 cites W2398511600 @default.
- W3162304792 cites W2561100838 @default.
- W3162304792 cites W2587415553 @default.
- W3162304792 cites W2593028774 @default.
- W3162304792 cites W2594591188 @default.
- W3162304792 cites W2743007007 @default.
- W3162304792 cites W2749319028 @default.
- W3162304792 cites W2749615987 @default.
- W3162304792 cites W2755388566 @default.
- W3162304792 cites W2790808295 @default.
- W3162304792 cites W2897169825 @default.
- W3162304792 cites W2936931391 @default.
- W3162304792 cites W2952485323 @default.
- W3162304792 cites W3014926848 @default.
- W3162304792 cites W3022626511 @default.
- W3162304792 cites W3107984511 @default.
- W3162304792 doi "https://doi.org/10.1101/2021.05.13.443970" @default.
- W3162304792 hasPublicationYear "2021" @default.
- W3162304792 type Work @default.
- W3162304792 sameAs 3162304792 @default.
- W3162304792 citedByCount "1" @default.
- W3162304792 countsByYear W31623047922022 @default.
- W3162304792 crossrefType "posted-content" @default.
- W3162304792 hasAuthorship W3162304792A5004502216 @default.
- W3162304792 hasAuthorship W3162304792A5016549258 @default.
- W3162304792 hasAuthorship W3162304792A5017678670 @default.
- W3162304792 hasAuthorship W3162304792A5075165777 @default.
- W3162304792 hasAuthorship W3162304792A5083226841 @default.
- W3162304792 hasAuthorship W3162304792A5089274703 @default.
- W3162304792 hasBestOaLocation W31623047921 @default.
- W3162304792 hasConcept C121332964 @default.
- W3162304792 hasConcept C1276947 @default.
- W3162304792 hasConcept C203014093 @default.
- W3162304792 hasConcept C37752432 @default.
- W3162304792 hasConcept C49039625 @default.
- W3162304792 hasConcept C55493867 @default.
- W3162304792 hasConcept C86803240 @default.
- W3162304792 hasConcept C95444343 @default.
- W3162304792 hasConceptScore W3162304792C121332964 @default.
- W3162304792 hasConceptScore W3162304792C1276947 @default.
- W3162304792 hasConceptScore W3162304792C203014093 @default.
- W3162304792 hasConceptScore W3162304792C37752432 @default.
- W3162304792 hasConceptScore W3162304792C49039625 @default.
- W3162304792 hasConceptScore W3162304792C55493867 @default.
- W3162304792 hasConceptScore W3162304792C86803240 @default.
- W3162304792 hasConceptScore W3162304792C95444343 @default.
- W3162304792 hasLocation W31623047921 @default.
- W3162304792 hasOpenAccess W3162304792 @default.
- W3162304792 hasPrimaryLocation W31623047921 @default.
- W3162304792 hasRelatedWork W2115547927 @default.
- W3162304792 hasRelatedWork W2136621634 @default.
- W3162304792 hasRelatedWork W2734207448 @default.
- W3162304792 hasRelatedWork W3044064086 @default.
- W3162304792 hasRelatedWork W3086093045 @default.
- W3162304792 hasRelatedWork W4243182520 @default.
- W3162304792 hasRelatedWork W4295681336 @default.
- W3162304792 hasRelatedWork W4297386564 @default.
- W3162304792 hasRelatedWork W4307336491 @default.
- W3162304792 hasRelatedWork W645255397 @default.
- W3162304792 isParatext "false" @default.
- W3162304792 isRetracted "false" @default.
- W3162304792 magId "3162304792" @default.
- W3162304792 workType "article" @default.