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- W3162344349 endingPage "2050" @default.
- W3162344349 startingPage "2050" @default.
- W3162344349 abstract "Background: Myeloid-derived suppressor cells (MDSCs) are implicated in the complex interplay involving graft-versus-leukemia (GVL) effects and graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HCT) in hematologic malignancies. Methods: A review of literature through PubMed was undertaken to summarize the published evidence on the pathophysiology and clinical implications of MDSCs in allo-HCT. Literature sources published in English since 1978 were searched, using the terms Natural Suppressor (NS) cells, MDSCs, GVHD, and allo-HCT. Results: In vivo studies demonstrated that MDSCs derived from mobilization protocols could strongly suppress allo-responses mediated by T cells and enhance T-Reg activity, thus inhibiting GVHD toxicity. However, the influence of MDSCs on the GVL effect is not fully defined. Conclusions: The induction or maintenance of MDSC suppressive function would be advantageous in suppressing inflammation associated with GVHD. Pathways involved in MDSC metabolism and the inflammasome signaling are a promising field of study to elucidate the function of MDSCs in the pathogenesis of GVHD and translate these findings to a clinical setting." @default.
- W3162344349 created "2021-05-24" @default.
- W3162344349 creator A5011406652 @default.
- W3162344349 creator A5018221472 @default.
- W3162344349 creator A5018345688 @default.
- W3162344349 creator A5051463822 @default.
- W3162344349 creator A5051639380 @default.
- W3162344349 creator A5052241210 @default.
- W3162344349 date "2021-05-11" @default.
- W3162344349 modified "2023-09-30" @default.
- W3162344349 title "The Role of Myeloid-Derived Suppressor Cells (MDSCs) in Graft-versus-Host Disease (GVHD)" @default.
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