Matches in SemOpenAlex for { <https://semopenalex.org/work/W3162476290> ?p ?o ?g. }
- W3162476290 endingPage "100036" @default.
- W3162476290 startingPage "100036" @default.
- W3162476290 abstract "Globally, malaria continues to be an enormous public health burden, with concomitant parasite-induced damage to the gastrointestinal (GI) barrier resulting in bacteremia-associated morbidity and mortality in both adults and children. Infected red blood cells sequester in and can occlude the GI microvasculature, ultimately leading to disruption of the tight and adherens junctions that would normally serve as a physical barrier to translocating enteric bacteria. Mast cell (MC) activation and translocation to the GI during malaria intensifies damage to the physical barrier and weakens the immunological barrier through the release of enzymes and factors that alter the host response to escaped enteric bacteria. In this context, activated MCs release Th2 cytokines, promoting a balanced Th1/Th2 response that increases local and systemic allergic inflammation while protecting the host from overwhelming Th1-mediated immunopathology. Beyond the mammalian host, recent studies in both the lab and field have revealed an association between a Th2-skewed host response and success of parasite transmission to mosquitoes, biology that is evocative of parasite manipulation of the mammalian host. Collectively, these observations suggest that malaria-induced bacteremia may be, in part, an unintended consequence of a Th2-shifted host response that promotes parasite survival and transmission. Future directions of this work include defining the factors and mechanisms that precede the development of bacteremia, which will enable the development of biomarkers to simplify diagnostics, the identification of therapeutic targets to improve patient outcomes and better understanding of the consequences of clinical interventions to transmission blocking strategies." @default.
- W3162476290 created "2021-05-24" @default.
- W3162476290 creator A5001614784 @default.
- W3162476290 creator A5076098071 @default.
- W3162476290 creator A5091249769 @default.
- W3162476290 date "2021-12-01" @default.
- W3162476290 modified "2023-09-28" @default.
- W3162476290 title "Malaria-induced bacteremia as a consequence of multiple parasite survival strategies" @default.
- W3162476290 cites W1479784763 @default.
- W3162476290 cites W1518773720 @default.
- W3162476290 cites W1588625776 @default.
- W3162476290 cites W1743814237 @default.
- W3162476290 cites W1792432231 @default.
- W3162476290 cites W183733028 @default.
- W3162476290 cites W1882327144 @default.
- W3162476290 cites W1907898035 @default.
- W3162476290 cites W1964163204 @default.
- W3162476290 cites W1965010109 @default.
- W3162476290 cites W1965701606 @default.
- W3162476290 cites W1966776937 @default.
- W3162476290 cites W1970113458 @default.
- W3162476290 cites W1970507744 @default.
- W3162476290 cites W1970891273 @default.
- W3162476290 cites W1971473545 @default.
- W3162476290 cites W1973262419 @default.
- W3162476290 cites W1973978881 @default.
- W3162476290 cites W1977647049 @default.
- W3162476290 cites W1977902343 @default.
- W3162476290 cites W1978673956 @default.
- W3162476290 cites W1986528258 @default.
- W3162476290 cites W1989142338 @default.
- W3162476290 cites W1996766178 @default.
- W3162476290 cites W2000422049 @default.
- W3162476290 cites W2000648336 @default.
- W3162476290 cites W2004633453 @default.
- W3162476290 cites W2008775556 @default.
- W3162476290 cites W2011436510 @default.
- W3162476290 cites W2012163637 @default.
- W3162476290 cites W2013566024 @default.
- W3162476290 cites W2016076204 @default.
- W3162476290 cites W2018815492 @default.
- W3162476290 cites W2018874666 @default.
- W3162476290 cites W2019628625 @default.
- W3162476290 cites W2020614593 @default.
- W3162476290 cites W2020639324 @default.
- W3162476290 cites W2022387897 @default.
- W3162476290 cites W2024005495 @default.
- W3162476290 cites W2026579891 @default.
- W3162476290 cites W2026948765 @default.
- W3162476290 cites W2028840184 @default.
- W3162476290 cites W2030538756 @default.
- W3162476290 cites W2030904598 @default.
- W3162476290 cites W2032516953 @default.
- W3162476290 cites W2034855715 @default.
- W3162476290 cites W2037422689 @default.
- W3162476290 cites W2038076623 @default.
- W3162476290 cites W2040391599 @default.
- W3162476290 cites W2040681861 @default.
- W3162476290 cites W2050811145 @default.
- W3162476290 cites W2053474593 @default.
- W3162476290 cites W2056374475 @default.
- W3162476290 cites W2061443292 @default.
- W3162476290 cites W2061866033 @default.
- W3162476290 cites W2063068982 @default.
- W3162476290 cites W2065605458 @default.
- W3162476290 cites W2067534856 @default.
- W3162476290 cites W2068773216 @default.
- W3162476290 cites W2076471618 @default.
- W3162476290 cites W2076588832 @default.
- W3162476290 cites W2079121101 @default.
- W3162476290 cites W2089884979 @default.
- W3162476290 cites W2091439605 @default.
- W3162476290 cites W2092422689 @default.
- W3162476290 cites W2094857959 @default.
- W3162476290 cites W2097211832 @default.
- W3162476290 cites W2098019855 @default.
- W3162476290 cites W2098876871 @default.
- W3162476290 cites W2100093202 @default.
- W3162476290 cites W2100483442 @default.
- W3162476290 cites W2102792995 @default.
- W3162476290 cites W2109383966 @default.
- W3162476290 cites W2110260516 @default.
- W3162476290 cites W2110427370 @default.
- W3162476290 cites W2113035769 @default.
- W3162476290 cites W2118425159 @default.
- W3162476290 cites W2119621206 @default.
- W3162476290 cites W2121816290 @default.
- W3162476290 cites W2122756053 @default.
- W3162476290 cites W2124096178 @default.
- W3162476290 cites W2125876865 @default.
- W3162476290 cites W2128205836 @default.
- W3162476290 cites W2132226772 @default.
- W3162476290 cites W2132415356 @default.
- W3162476290 cites W2133808995 @default.
- W3162476290 cites W2135760733 @default.
- W3162476290 cites W2136794260 @default.
- W3162476290 cites W2137225401 @default.
- W3162476290 cites W2139554478 @default.