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- W3162497822 abstract "Gene therapy serves as a promising therapy in the pipeline for treatment of epidermolysis bullosa (EB). However, with great promise, the risk of autoimmunity must be considered. While EB is a group of inherited blistering disorders caused by mutations in various skin proteins, autoimmune blistering diseases (AIBD) have a similar clinical phenotype and are caused by autoantibodies targeting skin antigens. Often, AIBD and EB have the same protein targeted through antibody or mutation, respectively. Moreover, EB patients are also reported to carry anti-skin antibodies of questionable pathogenicity. It has been speculated that activation of autoimmunity is both a consequence and cause of further skin deterioration in EB due to a state of chronic inflammation. Herein, we review the factors that facilitate the initiation of autoimmune and inflammatory responses to help understand the pathogenesis and therapeutic implications of the overlap between EB and AIBD. These may also help explain whether corrections of highly immunogenic portions of protein through gene therapy confers a greater risk towards developing AIBD." @default.
- W3162497822 created "2021-05-24" @default.
- W3162497822 creator A5001531097 @default.
- W3162497822 creator A5046632863 @default.
- W3162497822 creator A5051183891 @default.
- W3162497822 creator A5081860943 @default.
- W3162497822 creator A5090628603 @default.
- W3162497822 date "2021-05-17" @default.
- W3162497822 modified "2023-09-27" @default.
- W3162497822 title "A Review of Acquired Autoimmune Blistering Diseases in Inherited Epidermolysis Bullosa: Implications for the Future of Gene Therapy" @default.
- W3162497822 cites W1519045334 @default.
- W3162497822 cites W1646327013 @default.
- W3162497822 cites W179347434 @default.
- W3162497822 cites W1841646278 @default.
- W3162497822 cites W1870255478 @default.
- W3162497822 cites W1911382233 @default.
- W3162497822 cites W1912288378 @default.
- W3162497822 cites W1939030463 @default.
- W3162497822 cites W1959664751 @default.
- W3162497822 cites W1962973527 @default.
- W3162497822 cites W1973596924 @default.
- W3162497822 cites W1975817555 @default.
- W3162497822 cites W1975953978 @default.
- W3162497822 cites W1977630433 @default.
- W3162497822 cites W1989395082 @default.
- W3162497822 cites W1989738235 @default.
- W3162497822 cites W1990260528 @default.
- W3162497822 cites W1991092489 @default.
- W3162497822 cites W1994668373 @default.
- W3162497822 cites W1999004381 @default.
- W3162497822 cites W2003386949 @default.
- W3162497822 cites W2005698556 @default.
- W3162497822 cites W2010666451 @default.
- W3162497822 cites W2016850513 @default.
- W3162497822 cites W2018474348 @default.
- W3162497822 cites W2018932563 @default.
- W3162497822 cites W2019355614 @default.
- W3162497822 cites W2023723771 @default.
- W3162497822 cites W2026487158 @default.
- W3162497822 cites W2026704685 @default.
- W3162497822 cites W2034755524 @default.
- W3162497822 cites W2043914250 @default.
- W3162497822 cites W2046091963 @default.
- W3162497822 cites W2052645275 @default.
- W3162497822 cites W2053197957 @default.
- W3162497822 cites W2055307210 @default.
- W3162497822 cites W2056873082 @default.
- W3162497822 cites W2064681773 @default.
- W3162497822 cites W2065114016 @default.
- W3162497822 cites W2065951287 @default.
- W3162497822 cites W2068021720 @default.
- W3162497822 cites W2068448282 @default.
- W3162497822 cites W2070159172 @default.
- W3162497822 cites W2070278922 @default.
- W3162497822 cites W2075957187 @default.
- W3162497822 cites W2077256089 @default.
- W3162497822 cites W2084041908 @default.
- W3162497822 cites W2086077250 @default.
- W3162497822 cites W2086381423 @default.
- W3162497822 cites W2087481734 @default.
- W3162497822 cites W2089766865 @default.
- W3162497822 cites W2093562377 @default.
- W3162497822 cites W2093704426 @default.
- W3162497822 cites W2095479698 @default.
- W3162497822 cites W2097044062 @default.
- W3162497822 cites W2102143428 @default.
- W3162497822 cites W2111166435 @default.
- W3162497822 cites W2113829561 @default.
- W3162497822 cites W2113979191 @default.
- W3162497822 cites W2115200110 @default.
- W3162497822 cites W2119454174 @default.
- W3162497822 cites W2121837835 @default.
- W3162497822 cites W2122999524 @default.
- W3162497822 cites W2124234399 @default.
- W3162497822 cites W2127092918 @default.
- W3162497822 cites W2127800477 @default.
- W3162497822 cites W2141466223 @default.
- W3162497822 cites W2160572043 @default.
- W3162497822 cites W2160590831 @default.
- W3162497822 cites W2161318074 @default.
- W3162497822 cites W2163252791 @default.
- W3162497822 cites W2165576720 @default.
- W3162497822 cites W2167467353 @default.
- W3162497822 cites W2169459855 @default.
- W3162497822 cites W2169981839 @default.
- W3162497822 cites W2204532360 @default.
- W3162497822 cites W2228021409 @default.
- W3162497822 cites W2330187145 @default.
- W3162497822 cites W2525067819 @default.
- W3162497822 cites W2535184234 @default.
- W3162497822 cites W2539719512 @default.
- W3162497822 cites W2541937723 @default.
- W3162497822 cites W2546735337 @default.
- W3162497822 cites W2552343729 @default.
- W3162497822 cites W2555773301 @default.
- W3162497822 cites W2556050899 @default.
- W3162497822 cites W2560722415 @default.
- W3162497822 cites W2569563417 @default.