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• W3162648007 endingPage "5190" @default.
• W3162648007 startingPage "5190" @default.
• W3162648007 abstract "The redox chemistry of copper(II) is strongly modulated by the coordination to amyloid-β peptides and by the stability of the resulting complexes. Amino-terminal copper and nickel binding motifs (ATCUN) identified in truncated Aβ sequences starting with Phe4 show very high affinity for copper(II) ions. Herein, we study the oxidase activity of [Cu–Aβ4−x] and [Cu–Aβ1−x] complexes toward dopamine and other catechols. The results show that the CuII–ATCUN site is not redox-inert; the reduction of the metal is induced by coordination of catechol to the metal and occurs through an inner sphere reaction. The generation of a ternary [CuII–Aβ–catechol] species determines the efficiency of the oxidation, although the reaction rate is ruled by reoxidation of the CuI complex. In addition to the N-terminal coordination site, the two vicinal histidines, His13 and His14, provide a second Cu-binding motif. Catechol oxidation studies together with structural insight from the mixed dinuclear complexes Ni/Cu–Aβ4−x reveal that the His-tandem is able to bind CuII ions independently of the ATCUN site, but the N-terminal metal complexation reduces the conformational mobility of the peptide chain, preventing the binding and oxidative reactivity toward catechol of CuII bound to the secondary site." @default.
• W3162648007 created "2021-05-24" @default.
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• W3162648007 date "2021-05-14" @default.
• W3162648007 modified "2023-09-26" @default.
• W3162648007 title "Oxidase Reactivity of CuII Bound to N-Truncated Aβ Peptides Promoted by Dopamine" @default.
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• W3162648007 doi "https://doi.org/10.3390/ijms22105190" @default.
• W3162648007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8155989" @default.
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• W3162648007 hasPublicationYear "2021" @default.
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