Matches in SemOpenAlex for { <https://semopenalex.org/work/W3162740455> ?p ?o ?g. }
- W3162740455 endingPage "249" @default.
- W3162740455 startingPage "238" @default.
- W3162740455 abstract "We investigated the effect of caffeine and acetaminophen on power output during a 6-min performance test, peripheral fatigue, and muscle protein kinase A (PKA) substrate phosphorylation. Fourteen men [age (means ± SD): 26 ± 6 yr; V̇o2max: 63.9 ± 5.0 mL·min-1·kg-1] completed four randomized trials with acetaminophen (1,500 mg), caffeine (5 mg·kg body wt-1), combined caffeine and acetaminophen (caffeine + acetaminophen), or placebo. Mean power output during the 6-min performance test (placebo mean: 312 ± 41 W) was higher with caffeine (+5 W; 95% CI: 1 to 9; P = 0.017) and caffeine + acetaminophen (+6 W; 95% CI: 0 to 12; P = 0.049) than placebo, but not with acetaminophen (+1 W; 95% CI: -4 to 7; P = 0.529). Decline in quadriceps maximal isometric voluntary torque immediately after the performance test was lower (treatment × time; P = 0.035) with acetaminophen (-40 N·m; 95% CI: -53 to -30; P < 0.001) and caffeine + acetaminophen (-44 N·m; 95% CI: -58 to -30; P < 0.001) than placebo (-53 N·m; 95% CI: -71 to -39; P < 0.001) but was similar with caffeine (-54 N·m; 95% CI: -69 to -38; P < 0.001). Muscle phosphocreatine content decreased more during the performance test (treatment × time; P = 0.036) with caffeine + acetaminophen (-55 mmol·kg dry wt-1; 95% CI: -65 to -46; P < 0.001) than placebo (-40 mmol·kg dry wt-1; 95% CI: -52 to -24; P < 0.001). Muscle net lactate accumulation was not different from placebo (+85 mmol·kg dry wt-1; 95% CI: 60 to 110; P < 0.001) for any treatment (treatment × time; P = 0.066), being +75 mmol·kg dry wt-1 (95% CI: 51 to 99; P < 0.001) with caffeine, +76 mmol·kg dry wt-1 (95% CI: 58 to 96; P < 0.001) with acetaminophen, and +103 mmol·kg dry wt-1 (95% CI: 89 to 115; P < 0.001) with caffeine + acetaminophen. Decline in muscle ATP and glycogen content and increase in PKA substrate phosphorylation was not different between treatments (treatment × time; P > 0.1). Thus, acetaminophen provides no additive performance enhancing effect to caffeine during 6-min maximal cycling. In addition, change in PKA activity is likely not a major mechanism of performance improvement with caffeine.NEW & NOTEWORTHY Here, we show that acetaminophen does not provide additive performance improvement to caffeine during a 6-min cycling ergometer performance test, and that acetaminophen does not improve performance on its own. Neither substance affects peripheral fatigue, muscle glycolytic energy production, or phosphorylation of muscle proteins of importance for ion handling. In contrast to previous suggestions, increased epinephrine action on muscle cells does not appear to be a major contributor to the performance enhancement with caffeine." @default.
- W3162740455 created "2021-05-24" @default.
- W3162740455 creator A5015739435 @default.
- W3162740455 creator A5069324252 @default.
- W3162740455 creator A5075558427 @default.
- W3162740455 creator A5084335244 @default.
- W3162740455 creator A5091118593 @default.
- W3162740455 date "2021-07-01" @default.
- W3162740455 modified "2023-10-16" @default.
- W3162740455 title "No additive effect of acetaminophen when co-ingested with caffeine on cycling performance in well-trained young men" @default.
- W3162740455 cites W1880930944 @default.
- W3162740455 cites W1902966654 @default.
- W3162740455 cites W1964039440 @default.
- W3162740455 cites W1979773638 @default.
- W3162740455 cites W1984350609 @default.
- W3162740455 cites W1986583165 @default.
- W3162740455 cites W2001649338 @default.
- W3162740455 cites W2002533466 @default.
- W3162740455 cites W2017830929 @default.
- W3162740455 cites W2019281300 @default.
- W3162740455 cites W2020784556 @default.
- W3162740455 cites W2022928307 @default.
- W3162740455 cites W2028426353 @default.
- W3162740455 cites W2041661910 @default.
- W3162740455 cites W2047254168 @default.
- W3162740455 cites W2055040354 @default.
- W3162740455 cites W2064751005 @default.
- W3162740455 cites W2065630380 @default.
- W3162740455 cites W2069166877 @default.
- W3162740455 cites W2105174204 @default.
- W3162740455 cites W2108296560 @default.
- W3162740455 cites W2113047004 @default.
- W3162740455 cites W2114677544 @default.
- W3162740455 cites W2138430179 @default.
- W3162740455 cites W2145026508 @default.
- W3162740455 cites W2153258327 @default.
- W3162740455 cites W2154827465 @default.
- W3162740455 cites W2161000720 @default.
- W3162740455 cites W2171637006 @default.
- W3162740455 cites W2178178218 @default.
- W3162740455 cites W2178822554 @default.
- W3162740455 cites W2295693172 @default.
- W3162740455 cites W2319731779 @default.
- W3162740455 cites W2471168100 @default.
- W3162740455 cites W2530837299 @default.
- W3162740455 cites W2612463681 @default.
- W3162740455 cites W2613543312 @default.
- W3162740455 cites W2735995411 @default.
- W3162740455 cites W2783163015 @default.
- W3162740455 cites W2791163366 @default.
- W3162740455 cites W2893525731 @default.
- W3162740455 cites W2941221690 @default.
- W3162740455 cites W3002302272 @default.
- W3162740455 cites W3025621884 @default.
- W3162740455 cites W4255692377 @default.
- W3162740455 doi "https://doi.org/10.1152/japplphysiol.00108.2021" @default.
- W3162740455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34013747" @default.
- W3162740455 hasPublicationYear "2021" @default.
- W3162740455 type Work @default.
- W3162740455 sameAs 3162740455 @default.
- W3162740455 citedByCount "3" @default.
- W3162740455 countsByYear W31627404552021 @default.
- W3162740455 countsByYear W31627404552022 @default.
- W3162740455 crossrefType "journal-article" @default.
- W3162740455 hasAuthorship W3162740455A5015739435 @default.
- W3162740455 hasAuthorship W3162740455A5069324252 @default.
- W3162740455 hasAuthorship W3162740455A5075558427 @default.
- W3162740455 hasAuthorship W3162740455A5084335244 @default.
- W3162740455 hasAuthorship W3162740455A5091118593 @default.
- W3162740455 hasConcept C103486182 @default.
- W3162740455 hasConcept C126322002 @default.
- W3162740455 hasConcept C134018914 @default.
- W3162740455 hasConcept C140793950 @default.
- W3162740455 hasConcept C142724271 @default.
- W3162740455 hasConcept C204787440 @default.
- W3162740455 hasConcept C27081682 @default.
- W3162740455 hasConcept C2778500429 @default.
- W3162740455 hasConcept C2778722691 @default.
- W3162740455 hasConcept C42219234 @default.
- W3162740455 hasConcept C71924100 @default.
- W3162740455 hasConcept C86803240 @default.
- W3162740455 hasConcept C87813604 @default.
- W3162740455 hasConceptScore W3162740455C103486182 @default.
- W3162740455 hasConceptScore W3162740455C126322002 @default.
- W3162740455 hasConceptScore W3162740455C134018914 @default.
- W3162740455 hasConceptScore W3162740455C140793950 @default.
- W3162740455 hasConceptScore W3162740455C142724271 @default.
- W3162740455 hasConceptScore W3162740455C204787440 @default.
- W3162740455 hasConceptScore W3162740455C27081682 @default.
- W3162740455 hasConceptScore W3162740455C2778500429 @default.
- W3162740455 hasConceptScore W3162740455C2778722691 @default.
- W3162740455 hasConceptScore W3162740455C42219234 @default.
- W3162740455 hasConceptScore W3162740455C71924100 @default.
- W3162740455 hasConceptScore W3162740455C86803240 @default.
- W3162740455 hasConceptScore W3162740455C87813604 @default.
- W3162740455 hasFunder F4320317121 @default.
- W3162740455 hasIssue "1" @default.
- W3162740455 hasLocation W31627404551 @default.