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• W3162877582 abstract "Abstract Background Network models are well-established as very useful computational-statistical tools in cell biology. However, a genomic network model based only on gene expression data can, by definition, only infer gene co-expression networks. Hence, in order to infer gene regulatory patterns, it is necessary to also include data related to binding of regulatory factors to DNA. Results We propose a new dynamic genomic network model, for inferring patterns of genomic regulatory influence in dynamic processes such as development. Our model fuses experiment-specific gene expression data with publicly available DNA-binding data. The method we propose is computationally efficient, and can be applied to genome-wide data with tens of thousands of transcripts. Thus, our method is well suited for use as an exploratory tool for genome-wide data. We apply our method to data from human fetal cortical development, and our findings confirm genomic regulatory patterns which are recognised as being fundamental to neuronal development. Conclusions Our method provides a mathematical/computational toolbox which, when coupled with targeted experiments, will reveal and confirm important new functional genomic regulatory processes in mammalian development." @default.
• W3162877582 created "2021-05-24" @default.
• W3162877582 creator A5026422459 @default.
• W3162877582 date "2021-05-19" @default.
• W3162877582 modified "2023-09-25" @default.
• W3162877582 title "Fusion of single-cell transcriptome and DNA-binding data, for genomic network inference in cortical development" @default.
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• W3162877582 doi "https://doi.org/10.1101/2021.05.18.444638" @default.
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