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• W3163016502 endingPage "21.2021" @default.
• W3163016502 startingPage "ENEURO.0135" @default.
• W3163016502 abstract "Pyramidal neurons in rodent visual cortex homeostatically maintain their firing rates in vivo within a target range. In young cultured rat cortical neurons, Ca2+/calmodulin-dependent kinase IV (CaMKIV) signaling jointly regulates excitatory synaptic strength and intrinsic excitability to allow neurons to maintain their target firing rate. However, the role of CaMKIV signaling in regulating synaptic strength and intrinsic excitability in vivo has not been tested. Here, we show that in pyramidal neurons in visual cortex of juvenile male and female mice, CaMKIV signaling is not essential for the maintenance of basal synaptic or intrinsic properties. Neither CaMKIV conditional knock-down nor viral expression of dominant negative CaMKIV (dnCaMKIV) in vivo disrupts the intrinsic excitability or synaptic input strength of pyramidal neurons in primary visual cortex (V1), and CaMKIV signaling is not required for the increase in intrinsic excitability seen following monocular deprivation (MD). Viral expression of constitutively active CaMKIV (caCaMKIV) in vivo causes a complex disruption of the neuronal input/output function but does not affect synaptic input strength. Taken together, these results demonstrate that although augmented in vivo CaMKIV signaling can alter neuronal excitability, either endogenous CaMKIV signaling is dispensable for maintenance of excitability, or impaired CaMKIV signaling is robustly compensated." @default.
• W3163016502 created "2021-05-24" @default.
• W3163016502 creator A5063639195 @default.
• W3163016502 creator A5072749446 @default.
• W3163016502 date "2021-05-17" @default.
• W3163016502 modified "2023-10-16" @default.
• W3163016502 title "CaMKIV Signaling Is Not Essential for the Maintenance of Intrinsic or Synaptic Properties in Mouse Visual Cortex" @default.
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• W3163016502 doi "https://doi.org/10.1523/eneuro.0135-21.2021" @default.
• W3163016502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8260277" @default.
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