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- W3163120858 abstract "A common problem in many cancers is the resistance of some patients to common drugs or relapse. Hypoalbuminemia has been reported in some of resistant cancer patients.This article evaluates the usefulness of albumin in the treatment of drug-resistant cancers with hypoalbuminemia based on available evidences.Rapid metabolism and drug excretion from the body is one of the causes of drug resistance. Albumin is the major plasma protein to which almost all drugs are bound. There is some evidence that increasing drug binding to albumin has beneficial effects on drug efficacy in some cancers and cancer cells. On the other hand, some reports have shown that cancer cells can use albumin as the energy and amino acid source.We have hypothesized that in this particular group of cancers, adding albumin to a treatment regimen could have a beneficial effect on drug efficacy and dosage. In fact, excess albumin can prevent rapid metabolism of drug by increasing the fraction of albumin-bound drug, and can increase drug delivery to cancer cells due to the absorption of drug-albumin complex by cancer cells." @default.
- W3163120858 created "2021-05-24" @default.
- W3163120858 creator A5088360828 @default.
- W3163120858 creator A5089344970 @default.
- W3163120858 date "2021-05-25" @default.
- W3163120858 modified "2023-10-16" @default.
- W3163120858 title "Hypothesis of using albumin to improve drug efficacy in cancers accompanied by hypoalbuminemia" @default.
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- W3163120858 doi "https://doi.org/10.1080/00498254.2021.1929557" @default.
- W3163120858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33979263" @default.
- W3163120858 hasPublicationYear "2021" @default.