Matches in SemOpenAlex for { <https://semopenalex.org/work/W3163146175> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3163146175 endingPage "609" @default.
- W3163146175 startingPage "609" @default.
- W3163146175 abstract "Infections caused by multidrug-resistant Acinetobacter baumannii would benefit from the development of novel treatment approaches. Compounds that interfere with bacterial iron metabolism, such as iron chelators and gallium nitrate, have previously been shown to have antimicrobial activity against A. baumannii. In this study, we characterize the effect of LpxC inhibitors on the antimicrobial activity of previously characterized iron chelators, 2,2′-bipyridyl (BIP) and deferiprone (DFP), and gallium nitrate (Ga(NO3)3) against A. baumannii reference strains and multidrug-resistant clinical isolates. The LpxC inhibitor LpxC-2 was synergistic with BIP for 30% of strains tested (FICI values: 0.38–1.02), whereas inhibition with LpxC-4 was synergistic with BIP for 60% of strains tested (FICI values: 0.09–0.75). In time–kill assays, combinations of BIP with both LpxC inhibitors demonstrated synergistic activity, with a more than 3 log10 reduction in bacterial counts compared to BIP alone. LpxC-2 was synergistic with Ga(NO3)3 for 50% of strains tested (FICI values: 0.27–1.0), whereas LpxC-4 was synergistic with Ga(NO3)3 for all strains tested (FICI values: 0.08–≤0.50). In time–kill assays, combinations of Ga(NO3)3 with LpxC-2 and LpxC-4 decreased the growth of both strains compared to each compound separately; however, only the combination with LpxC-4 met the defined criteria for synergy. These results identify a novel synergy between two antimicrobial classes against A. baumannii strains." @default.
- W3163146175 created "2021-05-24" @default.
- W3163146175 creator A5009550294 @default.
- W3163146175 creator A5052183581 @default.
- W3163146175 creator A5080817598 @default.
- W3163146175 creator A5087945181 @default.
- W3163146175 date "2021-05-20" @default.
- W3163146175 modified "2023-10-07" @default.
- W3163146175 title "Inhibition of LpxC Increases the Activity of Iron Chelators and Gallium Nitrate in Multidrug-Resistant Acinetobacter baumannii" @default.
- W3163146175 cites W1984678233 @default.
- W3163146175 cites W2005271347 @default.
- W3163146175 cites W2016624659 @default.
- W3163146175 cites W2034012142 @default.
- W3163146175 cites W2055846623 @default.
- W3163146175 cites W2098074495 @default.
- W3163146175 cites W2102150398 @default.
- W3163146175 cites W2105838577 @default.
- W3163146175 cites W2115879450 @default.
- W3163146175 cites W2129148967 @default.
- W3163146175 cites W2135732696 @default.
- W3163146175 cites W2165464537 @default.
- W3163146175 cites W2417419189 @default.
- W3163146175 cites W2752297042 @default.
- W3163146175 cites W2798072540 @default.
- W3163146175 cites W2888936062 @default.
- W3163146175 cites W2893806747 @default.
- W3163146175 cites W2954935857 @default.
- W3163146175 cites W3138871370 @default.
- W3163146175 doi "https://doi.org/10.3390/antibiotics10050609" @default.
- W3163146175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8160660" @default.
- W3163146175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34065605" @default.
- W3163146175 hasPublicationYear "2021" @default.
- W3163146175 type Work @default.
- W3163146175 sameAs 3163146175 @default.
- W3163146175 citedByCount "2" @default.
- W3163146175 countsByYear W31631461752021 @default.
- W3163146175 countsByYear W31631461752023 @default.
- W3163146175 crossrefType "journal-article" @default.
- W3163146175 hasAuthorship W3163146175A5009550294 @default.
- W3163146175 hasAuthorship W3163146175A5052183581 @default.
- W3163146175 hasAuthorship W3163146175A5080817598 @default.
- W3163146175 hasAuthorship W3163146175A5087945181 @default.
- W3163146175 hasBestOaLocation W31631461751 @default.
- W3163146175 hasConcept C133936738 @default.
- W3163146175 hasConcept C185592680 @default.
- W3163146175 hasConcept C2776315533 @default.
- W3163146175 hasConcept C2776517179 @default.
- W3163146175 hasConcept C2776672577 @default.
- W3163146175 hasConcept C2777637488 @default.
- W3163146175 hasConcept C4937899 @default.
- W3163146175 hasConcept C501593827 @default.
- W3163146175 hasConcept C523546767 @default.
- W3163146175 hasConcept C54355233 @default.
- W3163146175 hasConcept C55493867 @default.
- W3163146175 hasConcept C86803240 @default.
- W3163146175 hasConcept C89423630 @default.
- W3163146175 hasConcept C98274493 @default.
- W3163146175 hasConceptScore W3163146175C133936738 @default.
- W3163146175 hasConceptScore W3163146175C185592680 @default.
- W3163146175 hasConceptScore W3163146175C2776315533 @default.
- W3163146175 hasConceptScore W3163146175C2776517179 @default.
- W3163146175 hasConceptScore W3163146175C2776672577 @default.
- W3163146175 hasConceptScore W3163146175C2777637488 @default.
- W3163146175 hasConceptScore W3163146175C4937899 @default.
- W3163146175 hasConceptScore W3163146175C501593827 @default.
- W3163146175 hasConceptScore W3163146175C523546767 @default.
- W3163146175 hasConceptScore W3163146175C54355233 @default.
- W3163146175 hasConceptScore W3163146175C55493867 @default.
- W3163146175 hasConceptScore W3163146175C86803240 @default.
- W3163146175 hasConceptScore W3163146175C89423630 @default.
- W3163146175 hasConceptScore W3163146175C98274493 @default.
- W3163146175 hasFunder F4320334923 @default.
- W3163146175 hasIssue "5" @default.
- W3163146175 hasLocation W31631461751 @default.
- W3163146175 hasLocation W31631461752 @default.
- W3163146175 hasLocation W31631461753 @default.
- W3163146175 hasOpenAccess W3163146175 @default.
- W3163146175 hasPrimaryLocation W31631461751 @default.
- W3163146175 hasRelatedWork W2265078347 @default.
- W3163146175 hasRelatedWork W2287954525 @default.
- W3163146175 hasRelatedWork W2774425402 @default.
- W3163146175 hasRelatedWork W3048903955 @default.
- W3163146175 hasRelatedWork W3090992129 @default.
- W3163146175 hasRelatedWork W3178472217 @default.
- W3163146175 hasRelatedWork W4283313781 @default.
- W3163146175 hasRelatedWork W4294956303 @default.
- W3163146175 hasRelatedWork W4306770696 @default.
- W3163146175 hasRelatedWork W4379012215 @default.
- W3163146175 hasVolume "10" @default.
- W3163146175 isParatext "false" @default.
- W3163146175 isRetracted "false" @default.
- W3163146175 magId "3163146175" @default.
- W3163146175 workType "article" @default.