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• W3163193709 abstract "Circulating biomarkers related to disease pathways involved in heart failure (HF) development and progression may be valuable tools for the diagnosis and management of HF [ [1] Chow S.L. Maisel A.S. Anand I. et al. Role of biomarkers for the prevention, assessment, and management of heart failure: a scientific statement from the American Heart Association. Circulation. 2017; 135: e1054-e1091 Crossref PubMed Scopus (277) Google Scholar , [2] Castiglione V. Aimo A. Vergaro G. Saccaro L. Passino C. Emdin M. Biomarkers for the diagnosis and management of heart failure. Heart Fail. Rev. 2021 Apr 14; (Epub ahead of print)https://doi.org/10.1007/s10741-021-10105-w Crossref Scopus (5) Google Scholar ]. Natriuretic peptides (NPs) are cardiac protective hormones released by cardiomyocytes in response to pressure or volume overload. Measurement of B-type NP (BNP) or N-terminal pro-BNP (NT-proBNP) is recommended for risk stratification. The added value of serial measurements and the interpretation of changes in NPs over time are less well established. Furthermore, NP levels should be interpreted on the light of many factors, including sex [ [3] Daniels L.B. Maisel A.S. Cardiovascular biomarkers and sex: the case for women. Nat. Rev. Cardiol. 2015; 12: 588-596 Crossref PubMed Scopus (59) Google Scholar ] as well as age, kidney function, arrhythmias and obesity, among others. Other biomarkers can provide additional information to NPs. Many biomarkers have been evaluated, linked to specific mechanisms of neurohormonal activation, myocardial damage, cardiac remodelling, inflammation/oxidative stress and comorbidities. High-sensitivity troponins (hs-Tn) and soluble suppression of tumorigenesis-2 (sST2) are currently the most promising biomarkers as additive tools for risk stratification [ [4] Aimo A. Januzzi Jr., J.L. Vergaro G. et al. Prognostic value of high-sensitivity troponin T in chronic heart failure: an individual patient data meta-analysis. Circulation. 2018; 137: 286-297 Crossref PubMed Scopus (96) Google Scholar , [5] Emdin M. Aimo A. Vergaro G. et al. sST2 predicts outcome in chronic heart failure beyond NT-proBNP and high-sensitivity troponin T. J. Am. Coll. Cardiol. 2018; 72: 2309-2320 Crossref PubMed Scopus (56) Google Scholar ], but additional biomarkers have been proposed, such as C-reactive protein or several indicators of renal function [ [6] Aimo A. Januzzi Jr., J.L. Vergaro G. et al. High-sensitivity troponin T, NT-proBNP and glomerular filtration rate: a multimarker strategy for risk stratification in chronic heart failure. Int. J. Cardiol. 2019; 277: 166-172 Abstract Full Text Full Text PDF PubMed Scopus (17) Google Scholar ]. Sex-specific temporal evolution of circulating biomarkers in patients with chronic heart failure with reduced ejection fractionInternational Journal of CardiologyVol. 334PreviewWe aimed to assess differences in clinical characteristics, prognosis, and the temporal evolution of circulating biomarkers in male and female patients with HFrEF. Full-Text PDF Open Access" @default.
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• W3163193709 date "2021-08-01" @default.
• W3163193709 modified "2023-09-27" @default.
• W3163193709 title "Longitudinal changes in cardiac biomarkers and outcome in heart failure: Sex-related differences" @default.
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• W3163193709 doi "https://doi.org/10.1016/j.ijcard.2021.05.027" @default.
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