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- W3163234592 abstract "3317 We performed gene expression profile analysis of non-small cell lung cancers (NSCLCs) and have been investigating molecules involved in pulmonary carcinogenesis for searching genes or gene products that serve as diagnostic markers or targets for new molecular therapies. Among them, we identified an IMS-TM26 gene (tentatively named) that encodes a protein of 824 amino acids with a unique structure possessing potential extracellular adhesion and protease domains, and a C-terminal transmembrane domain. Semi-quantitative RT-PCR documented increased expression of IMS-TM26 in 6 of 8 primary lung adenocarcinomas (ADCs) and 15 of 17 lung ADC cell lines examined. Immunohistochemical staining using tumor tissue microarrays consisting of 400 archived NSCLC specimens confirmed that IMS-TM26 protein is frequently increased in lung ADCs. We also identified the extracellular domain of IMS-TM26 protein was cleaved and secreted into the culture medium from NSCLC cells by western blot analysis. Subsequent analysis proved that the serum levels of IMS-TM26 protein detected by ELISA in NSCLCs patients were significantly higher than those in normal individuals (p" @default.
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- W3163234592 date "2004-04-01" @default.
- W3163234592 modified "2023-09-23" @default.
- W3163234592 title "Identification of IMS-TM26, as a novel tumor marker and therapeutic target for non-small cell lung cancer." @default.
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