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- W3163242735 abstract "목적: CRH has been proposed to regulate the placental clock. Since plasma CRH concentration is related to the onset timing of parturition, we predicted that it would affect intracellular Ca2+ concentration, which are themselves related to myometrial activation. We investigated the effects of CRH on intracellular Ca2+ concentration when oxytocin was administered in human myometrial smooth muscle cells(HSMCs) in in vitro conditions.방법: HSMCs for the study were obtained from term pregnant women (37-42 weeks; average age, 32 years; n = 5) who had no underlying disease (e.g., hypertension, diabetes, preeclampsia, intrauterine growth restriction) and were undergoing elective cesarean section. The final concentrations of oxytocin were 10-9, 10-8, 10-7, and 10-6 M.결과: When HSMCs are treated with oxytocin, the intracellular Ca2+ concentration increased with increasing oxytocin concentration. The intracellular Ca2+ in HSMCs treated with 1 pM(early pregnancy-like) CRH for 24 h decreased significantly compared to that in the control (p<0.05). At a CRH concentration of 103 pM(labor-like), the Ca2+ concentration did not significantly differ from that for the control.결론: In conclusion, when HSMCs were treated with low CRH concentrations, intracellular Ca2+ significantly decreased that could cause inhibition of uterine muscle activation." @default.
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- W3163242735 date "2016-01-01" @default.
- W3163242735 modified "2023-09-23" @default.
- W3163242735 title "Effects of Corticotropin-Releasing Hormone On Intracellular Ca2+ Concentration In Oxytocin Stimulated Human Term Pregnant Myometrium" @default.
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