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- W3163245612 abstract "Abstract Purpose : To investigate if molecular subtype is associated with outcome in stage 1 breast cancer (BC). Method : Tissue samples from 445 women with node-negative BC £15 mm, treated in 1986-2004, were classified into surrogate molecular subtypes (Luminal A-like, Luminal B-like, Her2-positive, and triple negative breast cancer (TNBC)). Information on treatment, recurrences and survival were gathered from medical records. Results : Tumour subtype was not associated with overall survival (OS). Luminal B-like and TNBC were associated with higher incidence of distant metastasis at 20 years. Luminal B-like and TNBC patients also had worse breast cancer specific survival (BCSS), although not statistically significant. Her2-positive BC was not associated with poor outcome despite no patient receiving Her2-targeted therapy. Conclusions : Stage 1 TNBC or Luminal B-like tumours behave more aggressively. Women with Her2+/ER+ tumours do not have an increased risk of distant metastasis or death, absent targeted treatment." @default.
- W3163245612 created "2021-05-24" @default.
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- W3163245612 date "2021-05-04" @default.
- W3163245612 modified "2023-09-25" @default.
- W3163245612 title "Correlation of Tumour Subtype With Long-term Outcome in Small Breast Carcinomas: A Swedish Population-based Retrospective Cohort Study" @default.
- W3163245612 doi "https://doi.org/10.21203/rs.3.rs-489830/v1" @default.
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