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- W3163308303 abstract "The Darwinian concept of evolution through natural selection has been revised and put on a solid physical basis, in a form which applies to self‐replicable macromolecules. Two new concepts are introduced: sequence space and quasi‐species. Evolutionary change in the DNA‐ or RNA‐sequence of a gene can be mapped as a trajectory in a sequence space of dimension ν, where ν corresponds to the number of changeable positions in the genomic sequence. Emphasis, however, is shifted from the single surviving wildtype, a single point in the sequence space, to the complex structure of the mutant distribution that constitutes the quasi‐species. Selection is equivalent to an establishment of the quasi‐species in a localized region of sequence space, subject to threshold conditions for the error rate and sequence length. Arrival of a new mutant may violate the local threshold condition and thereby lead to a displacement of the quasi‐species into a different region of sequence space. This transformation is similar to a pha..." @default.
- W3163308303 created "2021-05-24" @default.
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- W3163308303 date "1988-01-01" @default.
- W3163308303 modified "2023-10-17" @default.
- W3163308303 title "The physics of evolution" @default.
- W3163308303 doi "https://doi.org/10.1063/1.37874" @default.
- W3163308303 hasPublicationYear "1988" @default.
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