FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3163329501> ?p ?o ?g. }

• W3163329501 abstract "Abstract The emergence of multi-drug resistance bacteria poses great health theat. Therefore, it is a crucial demand to obtain new antibacterial drugs. Antimicrobial peptides (AMPs) have the characteristics of wide antimicrobial spectrum and lower drug resistance, hence, it is hopeful to substitute for classical antibiotics. In this study, two classic methods, comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA), were used to analysis the structural feature of small AMPs against S. aureus or E. coli respectively. Subsequently, Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) models (for S. aureus , CoMFA: Q 2 = 0.512, R 2 = 0.943, F = 59.916; CoMSIA: Q 2 = 0.645, R 2 = 0.993, F = 339.242; for E. Coli, CoMFA: Q 2 = 0.507, R 2 = 0.913, F = 66.862; CoMSIA: Q 2 = 0.573, R 2 = 0.966, F = 96.84) with good predictability and stability were constructed. Seven novel small AMPs were designed and synthesized based on the theoretical model. The novel AMPs showed potent antibacterial activity against S. aureus and E. coli without causing host toxicity. Our findings provide a potential therapeutic option using 3D-QSAR models guiding the design and modification of novel AMPs, to address the prevalent infections caused by MDR bacterial." @default.
• W3163329501 created "2021-05-24" @default.
• W3163329501 creator A5015069162 @default.
• W3163329501 creator A5019691939 @default.
• W3163329501 creator A5035742417 @default.
• W3163329501 creator A5043934458 @default.
• W3163329501 creator A5051806746 @default.
• W3163329501 creator A5073533587 @default.
• W3163329501 creator A5083716693 @default.
• W3163329501 creator A5084655226 @default.
• W3163329501 creator A5086685216 @default.
• W3163329501 date "2021-05-21" @default.
• W3163329501 modified "2023-10-16" @default.
• W3163329501 title "In Silicon Design of Antimicrobial Oligopeptides Based on 3D-QSAR Modelling and Bioassay Evaluation" @default.
• W3163329501 cites W1278793486 @default.
• W3163329501 cites W1587430592 @default.
• W3163329501 cites W1675925507 @default.
• W3163329501 cites W1713893508 @default.
• W3163329501 cites W1908459048 @default.
• W3163329501 cites W1969551758 @default.
• W3163329501 cites W1970621669 @default.
• W3163329501 cites W1970743383 @default.
• W3163329501 cites W1971808584 @default.
• W3163329501 cites W1973742248 @default.
• W3163329501 cites W1974768174 @default.
• W3163329501 cites W197620025 @default.
• W3163329501 cites W1977275366 @default.
• W3163329501 cites W1979697020 @default.
• W3163329501 cites W1982416589 @default.
• W3163329501 cites W1984607450 @default.
• W3163329501 cites W1987865999 @default.
• W3163329501 cites W1988916919 @default.
• W3163329501 cites W1992486144 @default.
• W3163329501 cites W1998521509 @default.
• W3163329501 cites W2002326403 @default.
• W3163329501 cites W2004731968 @default.
• W3163329501 cites W2007331931 @default.
• W3163329501 cites W2007807255 @default.
• W3163329501 cites W2016768959 @default.
• W3163329501 cites W2024602938 @default.
• W3163329501 cites W2024863394 @default.
• W3163329501 cites W2042198735 @default.
• W3163329501 cites W2068620810 @default.
• W3163329501 cites W2071663913 @default.
• W3163329501 cites W2071958671 @default.
• W3163329501 cites W2075474324 @default.
• W3163329501 cites W2075899459 @default.
• W3163329501 cites W2079665383 @default.
• W3163329501 cites W2083536977 @default.
• W3163329501 cites W2111433116 @default.
• W3163329501 cites W2117767830 @default.
• W3163329501 cites W2121654620 @default.
• W3163329501 cites W2128359216 @default.
• W3163329501 cites W2131192673 @default.
• W3163329501 cites W2132577466 @default.
• W3163329501 cites W2133043345 @default.
• W3163329501 cites W2136653513 @default.
• W3163329501 cites W2137536543 @default.
• W3163329501 cites W2142102316 @default.
• W3163329501 cites W2144081223 @default.
• W3163329501 cites W2145606531 @default.
• W3163329501 cites W2148950790 @default.
• W3163329501 cites W2160442093 @default.
• W3163329501 cites W2161239029 @default.
• W3163329501 cites W2168442227 @default.
• W3163329501 cites W2262166528 @default.
• W3163329501 cites W2345657752 @default.
• W3163329501 cites W2509207522 @default.
• W3163329501 cites W2553758814 @default.
• W3163329501 cites W2556828189 @default.
• W3163329501 cites W2563632637 @default.
• W3163329501 cites W2616251251 @default.
• W3163329501 cites W2884267293 @default.
• W3163329501 cites W83784112 @default.
• W3163329501 cites W943770219 @default.
• W3163329501 cites W2182363333 @default.
• W3163329501 doi "https://doi.org/10.21203/rs.3.rs-523910/v1" @default.
• W3163329501 hasPublicationYear "2021" @default.
• W3163329501 type Work @default.
• W3163329501 sameAs 3163329501 @default.
• W3163329501 citedByCount "0" @default.
• W3163329501 crossrefType "posted-content" @default.
• W3163329501 hasAuthorship W3163329501A5015069162 @default.
• W3163329501 hasAuthorship W3163329501A5019691939 @default.
• W3163329501 hasAuthorship W3163329501A5035742417 @default.
• W3163329501 hasAuthorship W3163329501A5043934458 @default.
• W3163329501 hasAuthorship W3163329501A5051806746 @default.
• W3163329501 hasAuthorship W3163329501A5073533587 @default.
• W3163329501 hasAuthorship W3163329501A5083716693 @default.
• W3163329501 hasAuthorship W3163329501A5084655226 @default.
• W3163329501 hasAuthorship W3163329501A5086685216 @default.
• W3163329501 hasBestOaLocation W31633295011 @default.
• W3163329501 hasConcept C164126121 @default.
• W3163329501 hasConcept C178790620 @default.
• W3163329501 hasConcept C185592680 @default.
• W3163329501 hasConcept C21951064 @default.
• W3163329501 hasConcept C2779489039 @default.
• W3163329501 hasConcept C4937899 @default.
• W3163329501 hasConcept C501593827 @default.
• W3163329501 hasConcept C523546767 @default.

• next