FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3163335597> ?p ?o ?g. }

• W3163335597 endingPage "114213" @default.
• W3163335597 startingPage "114213" @default.
• W3163335597 abstract "Herba taxilli (HT, Sangjisheng in Chinese), which is composed of the dried stems and leaves of Taxillus chinensis (DC.) Danser, has been commonly used to treat inflammation and arthritis in traditional Chinese medicine (TCM). Quercetin (Que) is a major active flavonoid component isolated from HT and is one of the quality control indexes of HT. In the clinical practice of TCM, formulas containing HT are commonly used to treat rheumatoid arthritis (RA). Recent studies have shown that Que exerts antiarthritic effects. However, the mechanism by which Que treatment affects RA is not fully understood.This study aimed to explore the antiarthritic activity of Que in a collagen-induced arthritis (CIA) mouse model and investigate the underlying mechanisms.The antiarthritic activity of Que was evaluated in a CIA mouse model by determining the paw clinical arthritis scores and left ankle thicknesses and by conducting micro-PET imaging and histopathological analysis of ankle joint tissues. The proinflammatory cytokine (IL-6, TNF-α, IL-1β, IL-8, IL-13, IL-17) levels in the serum and ankle joint tissues were measured by ELISA. Mitochondrial oxidative stress was assessed by biochemical methods. Mitochondrial biogenesis was analysed by RT-qPCR. The protein levels of silent information regulator 1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear respiratory factor 1 (NRF1), mitochondrial transcription factor A (TFAM), high-mobility group box 1 (HMGB1), Toll-like receptor 4 (TLR4), p38, phospho-p38, extracellular signal-regulated kinases (ERK)-1/2, phospho-ERK1/2, p65, and phospho-p65 in ankle joint tissues were detected by Western blot analysis. A total of 30 RA patients were recruited to investigate the relationship between the disease activity score (DAS28) and the SIRT1, PGC-1α, NRF1, and HMGB1 plasma levels.Que treatment decreased the clinical score and left ankle thickness of CIA mice, attenuated the synovial inflammation and hyperplasia and bone/cartilage destruction in ankle joints, and decreased the secretion of IL-6, TNF-α, IL-1β, IL-8, IL-13, and IL-17. Mechanistically, Que treatment improved impaired mitochondrial biogenesis and mitochondrial function by regulating the SIRT1/PGC-1α/NRF1/TFAM pathway and inhibited inflammation via the HMGB1/TLR4/p38/ERK1/2/NF-κB p65 pathway. Notably, epidemiological data revealed correlations between abnormal circulating levels of SIRT1, PGC-1α, NRF1, HMGB1 and RA disease activity in patients.Our data suggested a potential role of Que as a dietary therapeutic drug for RA treatment that may act through SIRT1 to target mitochondrial biogenesis. Additionally, the role of impaired mitochondrial biogenesis in RA was evaluated." @default.
• W3163335597 created "2021-05-24" @default.
• W3163335597 creator A5005827885 @default.
• W3163335597 creator A5016536083 @default.
• W3163335597 creator A5026642049 @default.
• W3163335597 creator A5029884827 @default.
• W3163335597 creator A5031620921 @default.
• W3163335597 creator A5031685579 @default.
• W3163335597 creator A5060059450 @default.
• W3163335597 creator A5065417133 @default.
• W3163335597 creator A5087631945 @default.
• W3163335597 date "2021-10-01" @default.
• W3163335597 modified "2023-10-15" @default.
• W3163335597 title "Quercetin-mediated SIRT1 activation attenuates collagen-induced mice arthritis" @default.
• W3163335597 cites W1727457558 @default.
• W3163335597 cites W1964767412 @default.
• W3163335597 cites W1969422685 @default.
• W3163335597 cites W1972204333 @default.
• W3163335597 cites W1973083723 @default.
• W3163335597 cites W1973404097 @default.
• W3163335597 cites W1978302160 @default.
• W3163335597 cites W1992371392 @default.
• W3163335597 cites W2005767172 @default.
• W3163335597 cites W2006756802 @default.
• W3163335597 cites W2015784113 @default.
• W3163335597 cites W2040797191 @default.
• W3163335597 cites W2042796333 @default.
• W3163335597 cites W2050425575 @default.
• W3163335597 cites W2075877600 @default.
• W3163335597 cites W2118994799 @default.
• W3163335597 cites W2128952811 @default.
• W3163335597 cites W2139339400 @default.
• W3163335597 cites W2144600435 @default.
• W3163335597 cites W2146607274 @default.
• W3163335597 cites W2155864960 @default.
• W3163335597 cites W2211397752 @default.
• W3163335597 cites W2267961811 @default.
• W3163335597 cites W2473118461 @default.
• W3163335597 cites W2473952238 @default.
• W3163335597 cites W2515947743 @default.
• W3163335597 cites W2527988826 @default.
• W3163335597 cites W2529645095 @default.
• W3163335597 cites W2553742787 @default.
• W3163335597 cites W2601394082 @default.
• W3163335597 cites W2743923106 @default.
• W3163335597 cites W2746181579 @default.
• W3163335597 cites W2770586957 @default.
• W3163335597 cites W2770642598 @default.
• W3163335597 cites W2801360402 @default.
• W3163335597 cites W2803558798 @default.
• W3163335597 cites W2803975545 @default.
• W3163335597 cites W2884150642 @default.
• W3163335597 cites W2890948470 @default.
• W3163335597 cites W2892913867 @default.
• W3163335597 cites W2902965685 @default.
• W3163335597 cites W2912016987 @default.
• W3163335597 cites W2924930352 @default.
• W3163335597 cites W2945886406 @default.
• W3163335597 cites W2951193994 @default.
• W3163335597 cites W2967573610 @default.
• W3163335597 cites W2969386395 @default.
• W3163335597 cites W2974422581 @default.
• W3163335597 cites W2983784381 @default.
• W3163335597 cites W2996365892 @default.
• W3163335597 cites W2997851069 @default.
• W3163335597 cites W2998625568 @default.
• W3163335597 cites W2999572345 @default.
• W3163335597 cites W3005574057 @default.
• W3163335597 cites W3010003321 @default.
• W3163335597 cites W3015521815 @default.
• W3163335597 cites W3017234249 @default.
• W3163335597 cites W3035097623 @default.
• W3163335597 cites W3036567300 @default.
• W3163335597 cites W3045774404 @default.
• W3163335597 cites W3085849825 @default.
• W3163335597 cites W3092984391 @default.
• W3163335597 cites W3109820229 @default.
• W3163335597 doi "https://doi.org/10.1016/j.jep.2021.114213" @default.
• W3163335597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34023442" @default.
• W3163335597 hasPublicationYear "2021" @default.
• W3163335597 type Work @default.
• W3163335597 sameAs 3163335597 @default.
• W3163335597 citedByCount "31" @default.
• W3163335597 countsByYear W31633355972021 @default.
• W3163335597 countsByYear W31633355972022 @default.
• W3163335597 countsByYear W31633355972023 @default.
• W3163335597 crossrefType "journal-article" @default.
• W3163335597 hasAuthorship W3163335597A5005827885 @default.
• W3163335597 hasAuthorship W3163335597A5016536083 @default.
• W3163335597 hasAuthorship W3163335597A5026642049 @default.
• W3163335597 hasAuthorship W3163335597A5029884827 @default.
• W3163335597 hasAuthorship W3163335597A5031620921 @default.
• W3163335597 hasAuthorship W3163335597A5031685579 @default.
• W3163335597 hasAuthorship W3163335597A5060059450 @default.
• W3163335597 hasAuthorship W3163335597A5065417133 @default.
• W3163335597 hasAuthorship W3163335597A5087631945 @default.
• W3163335597 hasConcept C126322002 @default.
• W3163335597 hasConcept C164027704 @default.

• next