Matches in SemOpenAlex for { <https://semopenalex.org/work/W3163359467> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3163359467 endingPage "1762" @default.
- W3163359467 startingPage "1754" @default.
- W3163359467 abstract "Abstract Background Vincristine might increase circulating platelet numbers but the functional capacity of these newly released platelets is unknown. Objective To evaluate and compare the functionality of mature and immature (reticulated) platelets after a single intravenous dose of vincristine in dogs. Animals Ten healthy purpose‐bred dogs. Methods Dogs prospectively received a single IV injection of 0.02 mg/kg vincristine or 0.9% saline. Before and after treatment on days 3, 5, and 7, platelets (resting and after thrombin stimulation) were assessed by flow cytometric determination of P‐selectin (CD62P) expression. Reticulated platelets were distinguished using thiazole orange (TO) staining. Results Relative to saline, vincristine administration increased platelet count from day 0 to day 7 (225 ± 58 to 273 ± 65 × 10 3 /μL, vs 299 ± 76.4 to 214 ± 20 × 10 3 /μL, P = .01) and increased percentage of reticulated platelets from day 0 to day 5 (3.9 ± 1.5% to 6.1 ± 1.6%, P = .02). On all days, reticulated platelets had greater resting expression of CD62P than did mature platelets (49.6 ± 4% vs 10.2 ± 1%, P ≤ .001). Across all days, CD62P expression by reticulated platelets in the vincristine and saline‐treated groups was not different when unstimulated ( P = .7) or after thrombin stimulation ( P = .33). Conclusions and Clinical Importance Reticulated platelets released in response to vincristine administration function similarly to mature platelets." @default.
- W3163359467 created "2021-05-24" @default.
- W3163359467 creator A5002690597 @default.
- W3163359467 creator A5025272490 @default.
- W3163359467 creator A5056599841 @default.
- W3163359467 creator A5063201782 @default.
- W3163359467 creator A5086232368 @default.
- W3163359467 date "2021-05-16" @default.
- W3163359467 modified "2023-10-12" @default.
- W3163359467 title "Platelet number and function in response to a single intravenous dose of vincristine" @default.
- W3163359467 cites W1508910120 @default.
- W3163359467 cites W1830273726 @default.
- W3163359467 cites W1966166845 @default.
- W3163359467 cites W1974930253 @default.
- W3163359467 cites W1999095358 @default.
- W3163359467 cites W2003567723 @default.
- W3163359467 cites W2014694741 @default.
- W3163359467 cites W2023339333 @default.
- W3163359467 cites W2055389941 @default.
- W3163359467 cites W2056193686 @default.
- W3163359467 cites W2082503024 @default.
- W3163359467 cites W2084687079 @default.
- W3163359467 cites W2089351969 @default.
- W3163359467 cites W2103009195 @default.
- W3163359467 cites W2106511650 @default.
- W3163359467 cites W2129260186 @default.
- W3163359467 cites W2131951761 @default.
- W3163359467 cites W2143831053 @default.
- W3163359467 cites W2148865221 @default.
- W3163359467 cites W2157524308 @default.
- W3163359467 cites W2533805524 @default.
- W3163359467 cites W2586334726 @default.
- W3163359467 cites W2742928906 @default.
- W3163359467 cites W2973232476 @default.
- W3163359467 cites W4253213227 @default.
- W3163359467 doi "https://doi.org/10.1111/jvim.16169" @default.
- W3163359467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8295686" @default.
- W3163359467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33993531" @default.
- W3163359467 hasPublicationYear "2021" @default.
- W3163359467 type Work @default.
- W3163359467 sameAs 3163359467 @default.
- W3163359467 citedByCount "4" @default.
- W3163359467 countsByYear W31633594672021 @default.
- W3163359467 countsByYear W31633594672022 @default.
- W3163359467 countsByYear W31633594672023 @default.
- W3163359467 crossrefType "journal-article" @default.
- W3163359467 hasAuthorship W3163359467A5002690597 @default.
- W3163359467 hasAuthorship W3163359467A5025272490 @default.
- W3163359467 hasAuthorship W3163359467A5056599841 @default.
- W3163359467 hasAuthorship W3163359467A5063201782 @default.
- W3163359467 hasAuthorship W3163359467A5086232368 @default.
- W3163359467 hasBestOaLocation W31633594672 @default.
- W3163359467 hasConcept C126322002 @default.
- W3163359467 hasConcept C203014093 @default.
- W3163359467 hasConcept C24998067 @default.
- W3163359467 hasConcept C2776694085 @default.
- W3163359467 hasConcept C2776755627 @default.
- W3163359467 hasConcept C2777292125 @default.
- W3163359467 hasConcept C2777397205 @default.
- W3163359467 hasConcept C2779429289 @default.
- W3163359467 hasConcept C553184892 @default.
- W3163359467 hasConcept C71924100 @default.
- W3163359467 hasConcept C89560881 @default.
- W3163359467 hasConceptScore W3163359467C126322002 @default.
- W3163359467 hasConceptScore W3163359467C203014093 @default.
- W3163359467 hasConceptScore W3163359467C24998067 @default.
- W3163359467 hasConceptScore W3163359467C2776694085 @default.
- W3163359467 hasConceptScore W3163359467C2776755627 @default.
- W3163359467 hasConceptScore W3163359467C2777292125 @default.
- W3163359467 hasConceptScore W3163359467C2777397205 @default.
- W3163359467 hasConceptScore W3163359467C2779429289 @default.
- W3163359467 hasConceptScore W3163359467C553184892 @default.
- W3163359467 hasConceptScore W3163359467C71924100 @default.
- W3163359467 hasConceptScore W3163359467C89560881 @default.
- W3163359467 hasIssue "4" @default.
- W3163359467 hasLocation W31633594671 @default.
- W3163359467 hasLocation W31633594672 @default.
- W3163359467 hasOpenAccess W3163359467 @default.
- W3163359467 hasPrimaryLocation W31633594671 @default.
- W3163359467 hasRelatedWork W1969551043 @default.
- W3163359467 hasRelatedWork W1971733201 @default.
- W3163359467 hasRelatedWork W2009344022 @default.
- W3163359467 hasRelatedWork W2037335007 @default.
- W3163359467 hasRelatedWork W2045190885 @default.
- W3163359467 hasRelatedWork W2313435602 @default.
- W3163359467 hasRelatedWork W2411620672 @default.
- W3163359467 hasRelatedWork W2413237794 @default.
- W3163359467 hasRelatedWork W2559245262 @default.
- W3163359467 hasRelatedWork W330292951 @default.
- W3163359467 hasVolume "35" @default.
- W3163359467 isParatext "false" @default.
- W3163359467 isRetracted "false" @default.
- W3163359467 magId "3163359467" @default.
- W3163359467 workType "article" @default.