FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3163436948> ?p ?o ?g. }

• W3163436948 endingPage "2848" @default.
• W3163436948 startingPage "2840" @default.
• W3163436948 abstract "Objective: The overexpression of transcription factor Sine oculis homeobox 1 (SIX1) is discovered in various malignant tumors and has been known to be closely associated with tumorigenesis, progression and prognosis. This study aims to determine the role of SIX1 in endometrial cancer (EC). Methods: In this study, we analyzed the SIX1 expression profile and the correlation with the corresponding clinical characteristics of EC samples from the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and Clinical Proteomic Tumor Analysis Consortium (CPTAC) databases. Wilcoxon signed-rank test was applied to analyze the difference between tumor group and control group. The potential biological processes or signaling pathways related to SIX1 activity in EC was also assessed. Results: The results showed that SIX1 was overexpressed in EC tissues compared to normal tissues (P=2.029e-15, P=6.25e-6). The SIX1 level was correlated with tumor grade (P=2.91e-4), peritoneal cytology (P=0.005), and the subsequent tumor surgery (P=1.169e-4). SIX1 expression was negatively associated with overall survival rate (P=4.241e-4, P=0.000241) and served as an independent factor that affected EC overall survival rate (P=0.005063), similar to other factors such as age, Figo stage, and tumor (T) stage. SIX1 participates in cancer pathogenesis through gene regulation that involves PI3K/AKT/MTOR signaling, mitotic spindle, G2M checkpoint, E2F targets, NOTCH signaling, glycolysis, cholesterol homeostasis, DNA repair and early estrogen response. Conclusions: Our data demonstrate that SIX1 is overexpressed in EC and associated with adverse clinicopathological outcomes, which can function as an independent factor for EC prognosis." @default.
• W3163436948 created "2021-05-24" @default.
• W3163436948 creator A5007638992 @default.
• W3163436948 creator A5032373512 @default.
• W3163436948 creator A5053831199 @default.
• W3163436948 creator A5054513227 @default.
• W3163436948 creator A5075155950 @default.
• W3163436948 date "2021-01-01" @default.
• W3163436948 modified "2023-10-03" @default.
• W3163436948 title "High expression of SIX1 is an independent predictor of poor prognosis in endometrial cancer." @default.
• W3163436948 cites W1483281366 @default.
• W3163436948 cites W1511389017 @default.
• W3163436948 cites W1531054984 @default.
• W3163436948 cites W1963945273 @default.
• W3163436948 cites W2001199164 @default.
• W3163436948 cites W2023640842 @default.
• W3163436948 cites W2076848909 @default.
• W3163436948 cites W2130410032 @default.
• W3163436948 cites W2153825747 @default.
• W3163436948 cites W2182443159 @default.
• W3163436948 cites W2272414565 @default.
• W3163436948 cites W2338844696 @default.
• W3163436948 cites W2409659629 @default.
• W3163436948 cites W2514168222 @default.
• W3163436948 cites W2564801645 @default.
• W3163436948 cites W2569786556 @default.
• W3163436948 cites W2587982228 @default.
• W3163436948 cites W2590033698 @default.
• W3163436948 cites W2591891921 @default.
• W3163436948 cites W2736730167 @default.
• W3163436948 cites W2765952964 @default.
• W3163436948 cites W2771812963 @default.
• W3163436948 cites W2786992500 @default.
• W3163436948 cites W2797612554 @default.
• W3163436948 cites W2804808720 @default.
• W3163436948 cites W2807811111 @default.
• W3163436948 cites W2889646458 @default.
• W3163436948 cites W2898893402 @default.
• W3163436948 cites W2904613353 @default.
• W3163436948 cites W2905793058 @default.
• W3163436948 cites W2909062624 @default.
• W3163436948 cites W2911188335 @default.
• W3163436948 cites W2943518530 @default.
• W3163436948 cites W2943578965 @default.
• W3163436948 cites W2968844944 @default.
• W3163436948 cites W2969474934 @default.
• W3163436948 cites W2986460757 @default.
• W3163436948 cites W2989806528 @default.
• W3163436948 cites W2995787675 @default.
• W3163436948 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8129400" @default.
• W3163436948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34017447" @default.
• W3163436948 hasPublicationYear "2021" @default.
• W3163436948 type Work @default.
• W3163436948 sameAs 3163436948 @default.
• W3163436948 citedByCount "5" @default.
• W3163436948 countsByYear W31634369482021 @default.
• W3163436948 countsByYear W31634369482022 @default.
• W3163436948 countsByYear W31634369482023 @default.
• W3163436948 crossrefType "journal-article" @default.
• W3163436948 hasAuthorship W3163436948A5007638992 @default.
• W3163436948 hasAuthorship W3163436948A5032373512 @default.
• W3163436948 hasAuthorship W3163436948A5053831199 @default.
• W3163436948 hasAuthorship W3163436948A5054513227 @default.
• W3163436948 hasAuthorship W3163436948A5075155950 @default.
• W3163436948 hasConcept C104317684 @default.
• W3163436948 hasConcept C121587040 @default.
• W3163436948 hasConcept C121608353 @default.
• W3163436948 hasConcept C126322002 @default.
• W3163436948 hasConcept C143998085 @default.
• W3163436948 hasConcept C2777088508 @default.
• W3163436948 hasConcept C502942594 @default.
• W3163436948 hasConcept C54355233 @default.
• W3163436948 hasConcept C555283112 @default.
• W3163436948 hasConcept C60644358 @default.
• W3163436948 hasConcept C62478195 @default.
• W3163436948 hasConcept C71924100 @default.
• W3163436948 hasConcept C86339819 @default.
• W3163436948 hasConcept C86554907 @default.
• W3163436948 hasConcept C86803240 @default.
• W3163436948 hasConceptScore W3163436948C104317684 @default.
• W3163436948 hasConceptScore W3163436948C121587040 @default.
• W3163436948 hasConceptScore W3163436948C121608353 @default.
• W3163436948 hasConceptScore W3163436948C126322002 @default.
• W3163436948 hasConceptScore W3163436948C143998085 @default.
• W3163436948 hasConceptScore W3163436948C2777088508 @default.
• W3163436948 hasConceptScore W3163436948C502942594 @default.
• W3163436948 hasConceptScore W3163436948C54355233 @default.
• W3163436948 hasConceptScore W3163436948C555283112 @default.
• W3163436948 hasConceptScore W3163436948C60644358 @default.
• W3163436948 hasConceptScore W3163436948C62478195 @default.
• W3163436948 hasConceptScore W3163436948C71924100 @default.
• W3163436948 hasConceptScore W3163436948C86339819 @default.
• W3163436948 hasConceptScore W3163436948C86554907 @default.
• W3163436948 hasConceptScore W3163436948C86803240 @default.
• W3163436948 hasIssue "4" @default.
• W3163436948 hasOpenAccess W3163436948 @default.
• W3163436948 hasRelatedWork W1449548119 @default.
• W3163436948 hasRelatedWork W1978071683 @default.

• next